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• W2957604849 startingPage "204" @default.
• W2957604849 abstract "Development of cisplatin (DDP)-resistance is a major challenge that largely limits the efficacy of chemotherapy for osteosarcoma. LncRNA Taurine up-regulated gene 1 (TUG1) is a recently identified oncogenic lncRNA that has been involved in chemo-resistance of various cancers. In this study, over-expression of TUG1 was found in two osteosarcoma cell lines resistant to DDP (Saos-2/DDP, MG-63/DDP). Knockdown of TUG1 inhibited the DDP-resistance and promoted the cytotoxicity and apoptosis induced by DDP in Saos-2/DDP and MG-63/DDP cells. TUG1 knockdown also markedly inhibited the expression level of MET and p-Akt. In conclusion, knockdown of TUG1 suppressed cell growth and increased apoptotic rate under DDP treatment possibly via regulating MET/Akt signalling pathway." @default.
• W2957604849 created "2019-07-23" @default.
• W2957604849 creator A5015970630 @default.
• W2957604849 creator A5018755877 @default.
• W2957604849 creator A5044188620 @default.
• W2957604849 date "2019-07-24" @default.
• W2957604849 modified "2023-09-27" @default.
• W2957604849 title "Anticancer potential of TUG1 knockdown in cisplatin-resistant osteosarcoma through inhibition of MET/Akt signalling" @default.
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• W2957604849 doi "https://doi.org/10.1080/1061186x.2019.1644651" @default.
• W2957604849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31305159" @default.
• W2957604849 hasPublicationYear "2019" @default.
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