FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2957636769> ?p ?o ?g. }

• W2957636769 abstract "Liqui-pellet is a new dosage form stemming from pelletisation technology and concept from liquisolid technology. In spite of liqui-pellet overcoming a major hurdle in liquisolid technology through achieving excellent flow property with high liquid load factor, the formulation requires to be optimised in order to improve drug release rate. Liqui-pellets of naproxen containing Tween 80, Primojel, Avicel and Aerosil were extruded and spheronised. Flowability test confirmed that all liqui-pellet formulations have excellent-good flow property (Carr's index between 3.9-11.17%), including liqui-pellets with a high liquid load factor of 1.52, where 38% of the total mass is co-solvent. This shows a relatively high liquid load factor can be achieved in liqui-pellet without compromising the flowability, which is one of the key novelty of this work. It was found that the improved drug release rate was due to the remarkably improved disintegration of the supposedly non-disintegrating microcrystalline-based pellet; the optimised liqui-pellet seems to explode into fragments in the dissolution medium. At pH 1.2, the optimised formulation had ~ 10% more drug release than non-optimised formulation after 2 h, and at pH 7.4, the drug release of the optimised pellet was nearing 100% at ~ 15 min, whereas the none-optimised pellet only achieved ~ 79% drug release after 2 h. DSC and XRPD indicated an increase in the dissolution rate could be due to molecularly dispersion of naproxen in the pellets. Overall results showed that liqui-pellet exhibited an enhanced drug release and the capacity for high liquid load factor whilst maintaining excellent flowability, rendering it a potentially commercially feasible drug delivery system." @default.
• W2957636769 created "2019-07-23" @default.
• W2957636769 creator A5023571572 @default.
• W2957636769 creator A5035073798 @default.
• W2957636769 creator A5055400823 @default.
• W2957636769 date "2019-07-08" @default.
• W2957636769 modified "2023-10-04" @default.
• W2957636769 title "Optimising the release rate of naproxen liqui-pellet: a new technology for emerging novel oral dosage form" @default.
• W2957636769 cites W1697337825 @default.
• W2957636769 cites W1954576198 @default.
• W2957636769 cites W1968706872 @default.
• W2957636769 cites W1972476762 @default.
• W2957636769 cites W1975509513 @default.
• W2957636769 cites W1994041894 @default.
• W2957636769 cites W1997384329 @default.
• W2957636769 cites W2001312320 @default.
• W2957636769 cites W2002717193 @default.
• W2957636769 cites W2010351913 @default.
• W2957636769 cites W2011930026 @default.
• W2957636769 cites W2015767901 @default.
• W2957636769 cites W2032646967 @default.
• W2957636769 cites W2037696353 @default.
• W2957636769 cites W2046208687 @default.
• W2957636769 cites W2053900295 @default.
• W2957636769 cites W2054246330 @default.
• W2957636769 cites W2055444002 @default.
• W2957636769 cites W2057492682 @default.
• W2957636769 cites W2064681790 @default.
• W2957636769 cites W2066927092 @default.
• W2957636769 cites W2069506489 @default.
• W2957636769 cites W2072690238 @default.
• W2957636769 cites W2076793884 @default.
• W2957636769 cites W2078839736 @default.
• W2957636769 cites W2079694316 @default.
• W2957636769 cites W2080768821 @default.
• W2957636769 cites W2082612497 @default.
• W2957636769 cites W2087050645 @default.
• W2957636769 cites W2087659180 @default.
• W2957636769 cites W2105767281 @default.
• W2957636769 cites W2115439624 @default.
• W2957636769 cites W2140067957 @default.
• W2957636769 cites W2164125860 @default.
• W2957636769 cites W2166580946 @default.
• W2957636769 cites W2171601916 @default.
• W2957636769 cites W2195901151 @default.
• W2957636769 cites W2254341845 @default.
• W2957636769 cites W2334439334 @default.
• W2957636769 cites W2954071372 @default.
• W2957636769 doi "https://doi.org/10.1007/s13346-019-00659-6" @default.
• W2957636769 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6978301" @default.
• W2957636769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31286452" @default.
• W2957636769 hasPublicationYear "2019" @default.
• W2957636769 type Work @default.
• W2957636769 sameAs 2957636769 @default.
• W2957636769 citedByCount "19" @default.
• W2957636769 countsByYear W29576367692020 @default.
• W2957636769 countsByYear W29576367692021 @default.
• W2957636769 countsByYear W29576367692022 @default.
• W2957636769 countsByYear W29576367692023 @default.
• W2957636769 crossrefType "journal-article" @default.
• W2957636769 hasAuthorship W2957636769A5023571572 @default.
• W2957636769 hasAuthorship W2957636769A5035073798 @default.
• W2957636769 hasAuthorship W2957636769A5055400823 @default.
• W2957636769 hasBestOaLocation W29576367691 @default.
• W2957636769 hasConcept C142724271 @default.
• W2957636769 hasConcept C159985019 @default.
• W2957636769 hasConcept C178790620 @default.
• W2957636769 hasConcept C17923525 @default.
• W2957636769 hasConcept C185592680 @default.
• W2957636769 hasConcept C192562407 @default.
• W2957636769 hasConcept C204787440 @default.
• W2957636769 hasConcept C2778115740 @default.
• W2957636769 hasConcept C2780584874 @default.
• W2957636769 hasConcept C43617362 @default.
• W2957636769 hasConcept C71924100 @default.
• W2957636769 hasConcept C77281830 @default.
• W2957636769 hasConcept C88380143 @default.
• W2957636769 hasConceptScore W2957636769C142724271 @default.
• W2957636769 hasConceptScore W2957636769C159985019 @default.
• W2957636769 hasConceptScore W2957636769C178790620 @default.
• W2957636769 hasConceptScore W2957636769C17923525 @default.
• W2957636769 hasConceptScore W2957636769C185592680 @default.
• W2957636769 hasConceptScore W2957636769C192562407 @default.
• W2957636769 hasConceptScore W2957636769C204787440 @default.
• W2957636769 hasConceptScore W2957636769C2778115740 @default.
• W2957636769 hasConceptScore W2957636769C2780584874 @default.
• W2957636769 hasConceptScore W2957636769C43617362 @default.
• W2957636769 hasConceptScore W2957636769C71924100 @default.
• W2957636769 hasConceptScore W2957636769C77281830 @default.
• W2957636769 hasConceptScore W2957636769C88380143 @default.
• W2957636769 hasFunder F4320320325 @default.
• W2957636769 hasLocation W29576367691 @default.
• W2957636769 hasLocation W29576367692 @default.
• W2957636769 hasLocation W29576367693 @default.
• W2957636769 hasLocation W29576367694 @default.
• W2957636769 hasLocation W29576367695 @default.
• W2957636769 hasLocation W29576367696 @default.
• W2957636769 hasOpenAccess W2957636769 @default.
• W2957636769 hasPrimaryLocation W29576367691 @default.
• W2957636769 hasRelatedWork W1986061657 @default.

• next