Matches in SemOpenAlex for { <https://semopenalex.org/work/W295776039> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W295776039 endingPage "272" @default.
- W295776039 startingPage "256" @default.
- W295776039 abstract "In male rats a sex-dependent protein fraction in the liver is found to disappear on treatment with cyproterone or reserpine. This protein fraction is dependent on the endogenous testosterone production. Besides this effect the interaction of testosterone and cyproterone was investigated in the prostate gland of the rat. The activity of prostatic nuclear aggregates to synthesize RNA was retarded in castrated rats. This could be brought to normal by exogenous testosterone. Simultaneous treatment with cyproterone inhibited the testosterone action completely. To look for more simple biological systems we investigated the anti-androgenic action of cyproterone, reserpine and other compounds in microbial systems. Using testosterone as inducer for the synthesis of 20ß-hydroxy steroid dehydrogenase (HSDase) in Streptomyces hydrogenans, HSDase- induction was found to be very sensitive to the addition of cyproterone, reserpine, ergocornine and diethylstilbestrol. In the presence of cyproterone induction of HSDase-synthesis is significantly inhibited, which may be due to a competition at the specific receptor. However, no antagonism between progesterone and cyproterone is observed in animals and in Streptomyces. The primary response of an inducer is accompanied by its initial binding to the receptor, which is found in Streptomyces hydrogenans as an acidic protein. Its molecular weight is estimated to be 150 000 or more and it does not contain any strongly bound nucleic acids or nucleotides. After proteolytic digestion this protein fraction loses bound steroids. After in vivo incubation bound steroids are partly altered. There is no final conclusion about the number or heterogeneity of the binding protein(s) for inducing steroids. The steroid binding protein shows binding capacity for steroids in cell free system by equilibrium dialysis too." @default.
- W295776039 created "2016-06-24" @default.
- W295776039 creator A5061892693 @default.
- W295776039 creator A5075879261 @default.
- W295776039 creator A5087614547 @default.
- W295776039 date "1969-01-01" @default.
- W295776039 modified "2023-09-23" @default.
- W295776039 title "Steroid Antagonists: Their Mechanism of Action" @default.
- W295776039 cites W1981789552 @default.
- W295776039 cites W1985213849 @default.
- W295776039 cites W1985402277 @default.
- W295776039 cites W1987419970 @default.
- W295776039 cites W2016794039 @default.
- W295776039 cites W2017700029 @default.
- W295776039 cites W2024919310 @default.
- W295776039 cites W2040466088 @default.
- W295776039 cites W2040524868 @default.
- W295776039 cites W2072068261 @default.
- W295776039 cites W2079163015 @default.
- W295776039 cites W2084621652 @default.
- W295776039 cites W2087979921 @default.
- W295776039 cites W2319391110 @default.
- W295776039 cites W2321354682 @default.
- W295776039 cites W2417287364 @default.
- W295776039 doi "https://doi.org/10.1016/b978-0-08-006942-5.50019-9" @default.
- W295776039 hasPublicationYear "1969" @default.
- W295776039 type Work @default.
- W295776039 sameAs 295776039 @default.
- W295776039 citedByCount "0" @default.
- W295776039 crossrefType "book-chapter" @default.
- W295776039 hasAuthorship W295776039A5061892693 @default.
- W295776039 hasAuthorship W295776039A5075879261 @default.
- W295776039 hasAuthorship W295776039A5087614547 @default.
- W295776039 hasConcept C126322002 @default.
- W295776039 hasConcept C134018914 @default.
- W295776039 hasConcept C185592680 @default.
- W295776039 hasConcept C202751555 @default.
- W295776039 hasConcept C2776120743 @default.
- W295776039 hasConcept C2776306840 @default.
- W295776039 hasConcept C2777155358 @default.
- W295776039 hasConcept C2777842393 @default.
- W295776039 hasConcept C2777911890 @default.
- W295776039 hasConcept C2779279991 @default.
- W295776039 hasConcept C2780902042 @default.
- W295776039 hasConcept C55493867 @default.
- W295776039 hasConcept C71315377 @default.
- W295776039 hasConcept C71924100 @default.
- W295776039 hasConcept C86803240 @default.
- W295776039 hasConceptScore W295776039C126322002 @default.
- W295776039 hasConceptScore W295776039C134018914 @default.
- W295776039 hasConceptScore W295776039C185592680 @default.
- W295776039 hasConceptScore W295776039C202751555 @default.
- W295776039 hasConceptScore W295776039C2776120743 @default.
- W295776039 hasConceptScore W295776039C2776306840 @default.
- W295776039 hasConceptScore W295776039C2777155358 @default.
- W295776039 hasConceptScore W295776039C2777842393 @default.
- W295776039 hasConceptScore W295776039C2777911890 @default.
- W295776039 hasConceptScore W295776039C2779279991 @default.
- W295776039 hasConceptScore W295776039C2780902042 @default.
- W295776039 hasConceptScore W295776039C55493867 @default.
- W295776039 hasConceptScore W295776039C71315377 @default.
- W295776039 hasConceptScore W295776039C71924100 @default.
- W295776039 hasConceptScore W295776039C86803240 @default.
- W295776039 hasLocation W2957760391 @default.
- W295776039 hasOpenAccess W295776039 @default.
- W295776039 hasPrimaryLocation W2957760391 @default.
- W295776039 hasRelatedWork W1982195695 @default.
- W295776039 hasRelatedWork W1987621412 @default.
- W295776039 hasRelatedWork W1989148468 @default.
- W295776039 hasRelatedWork W2005402639 @default.
- W295776039 hasRelatedWork W2026307684 @default.
- W295776039 hasRelatedWork W2050709457 @default.
- W295776039 hasRelatedWork W2062690991 @default.
- W295776039 hasRelatedWork W2075762636 @default.
- W295776039 hasRelatedWork W2100489643 @default.
- W295776039 hasRelatedWork W2142416343 @default.
- W295776039 isParatext "false" @default.
- W295776039 isRetracted "false" @default.
- W295776039 magId "295776039" @default.
- W295776039 workType "book-chapter" @default.