FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2957788206> ?p ?o ?g. }

• W2957788206 endingPage "111496" @default.
• W2957788206 startingPage "111496" @default.
• W2957788206 abstract "Hepatocellular carcinoma (HCC) is one of the most common types of cancer worldwide, and there is currently no effective therapeutic strategy in clinical practice. Gene therapy has great potential for decreasing tumor-induced mortality but has been clinically limited because of the lack of tumor-specific targets and insufficient gene transfer. The study of targeted transport of therapeutic genes in HCC treatment seems to be very important. In this study, we evaluated a gene therapy approach targeting HCC using the herpes simplex virus thymidine kinase/ganciclovir (HSVtk/GCV) suicide gene system in HCC cell lines and in an in vivo human HCC xenograft mouse model. GP73-modified liposomes targeted gene delivery to the tumor tissue, and the survivin promoter drove HSVtk expression in the HCC cells. Our results showed that the survivin promoter was specifically activated in tumor cells and HSVtk was expressed selectively in tumor cells. Combined with GCV treatment, HSVtk expression resulted in suppression of HCC cell proliferation via enhancing apoptosis. Moreover, tail vein injection of GP73-HSVtk significantly suppressed the growth of xenograft tumors through an apoptosis-dependent pathway and extended the survival of tumor-bearing mice without damaging the mice liver functions. Taken together, this study demonstrates an effective cancer-specific gene therapy strategy using the herpes simplex virus thymidine kinase/ganciclovir (HSVtk/GCV) suicide gene system for HCC that can be further developed for future clinical trials." @default.
• W2957788206 created "2019-07-23" @default.
• W2957788206 creator A5006253019 @default.
• W2957788206 creator A5008857498 @default.
• W2957788206 creator A5011639161 @default.
• W2957788206 creator A5016063619 @default.
• W2957788206 creator A5019236716 @default.
• W2957788206 creator A5022256556 @default.
• W2957788206 creator A5023858361 @default.
• W2957788206 creator A5026380838 @default.
• W2957788206 creator A5026767083 @default.
• W2957788206 creator A5031069096 @default.
• W2957788206 creator A5037993198 @default.
• W2957788206 creator A5039334635 @default.
• W2957788206 creator A5040144141 @default.
• W2957788206 creator A5043239050 @default.
• W2957788206 creator A5045864062 @default.
• W2957788206 creator A5048631551 @default.
• W2957788206 creator A5049464184 @default.
• W2957788206 creator A5052291087 @default.
• W2957788206 creator A5053806866 @default.
• W2957788206 creator A5058484759 @default.
• W2957788206 creator A5062796567 @default.
• W2957788206 creator A5065700566 @default.
• W2957788206 creator A5071230215 @default.
• W2957788206 creator A5077068949 @default.
• W2957788206 creator A5077069400 @default.
• W2957788206 date "2019-10-01" @default.
• W2957788206 modified "2023-10-15" @default.
• W2957788206 title "Golgi membrane protein GP73 modified-liposome mediates the antitumor effect of survivin promoter-driven HSVtk in hepatocellular carcinoma" @default.
• W2957788206 cites W1481302076 @default.
• W2957788206 cites W1527782622 @default.
• W2957788206 cites W1598512923 @default.
• W2957788206 cites W1667099939 @default.
• W2957788206 cites W1795530843 @default.
• W2957788206 cites W1965194146 @default.
• W2957788206 cites W1967346946 @default.
• W2957788206 cites W1972417002 @default.
• W2957788206 cites W1972728563 @default.
• W2957788206 cites W1973816981 @default.
• W2957788206 cites W1978970861 @default.
• W2957788206 cites W1983109993 @default.
• W2957788206 cites W1997128429 @default.
• W2957788206 cites W1998530967 @default.
• W2957788206 cites W2014440272 @default.
• W2957788206 cites W2031984036 @default.
• W2957788206 cites W2036663141 @default.
• W2957788206 cites W2041062187 @default.
• W2957788206 cites W2047575632 @default.
• W2957788206 cites W2058601505 @default.
• W2957788206 cites W2061138204 @default.
• W2957788206 cites W2064580048 @default.
• W2957788206 cites W2067175668 @default.
• W2957788206 cites W2069409056 @default.
• W2957788206 cites W2077850392 @default.
• W2957788206 cites W2078188006 @default.
• W2957788206 cites W2079292721 @default.
• W2957788206 cites W2086427055 @default.
• W2957788206 cites W2097991539 @default.
• W2957788206 cites W2115608911 @default.
• W2957788206 cites W2140528724 @default.
• W2957788206 cites W2155380618 @default.
• W2957788206 cites W2155892963 @default.
• W2957788206 cites W2170533808 @default.
• W2957788206 cites W2231952962 @default.
• W2957788206 cites W2292767475 @default.
• W2957788206 cites W2324324647 @default.
• W2957788206 cites W2327812806 @default.
• W2957788206 cites W2329340068 @default.
• W2957788206 cites W2338526660 @default.
• W2957788206 cites W241538738 @default.
• W2957788206 cites W2613163105 @default.
• W2957788206 cites W2618652138 @default.
• W2957788206 cites W2621900515 @default.
• W2957788206 cites W2622678622 @default.
• W2957788206 cites W2796729556 @default.
• W2957788206 cites W2804156286 @default.
• W2957788206 cites W2890479193 @default.
• W2957788206 cites W4234381551 @default.
• W2957788206 cites W4245483584 @default.
• W2957788206 doi "https://doi.org/10.1016/j.yexcr.2019.111496" @default.
• W2957788206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31306654" @default.
• W2957788206 hasPublicationYear "2019" @default.
• W2957788206 type Work @default.
• W2957788206 sameAs 2957788206 @default.
• W2957788206 citedByCount "3" @default.
• W2957788206 countsByYear W29577882062020 @default.
• W2957788206 countsByYear W29577882062021 @default.
• W2957788206 countsByYear W29577882062022 @default.
• W2957788206 crossrefType "journal-article" @default.
• W2957788206 hasAuthorship W2957788206A5006253019 @default.
• W2957788206 hasAuthorship W2957788206A5008857498 @default.
• W2957788206 hasAuthorship W2957788206A5011639161 @default.
• W2957788206 hasAuthorship W2957788206A5016063619 @default.
• W2957788206 hasAuthorship W2957788206A5019236716 @default.
• W2957788206 hasAuthorship W2957788206A5022256556 @default.
• W2957788206 hasAuthorship W2957788206A5023858361 @default.
• W2957788206 hasAuthorship W2957788206A5026380838 @default.

• next