FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2957790583> ?p ?o ?g. }

• W2957790583 endingPage "1277" @default.
• W2957790583 startingPage "1267" @default.
• W2957790583 abstract "Purpose To examine the utility of electronic health records from a routine care setting in assessing comparative effectiveness of fourth-line anti-hypertensive drugs to treat resistant hypertension. Methods We conducted a cohort study using the Clinical Practice Research Datalink: a repository of electronic health records from UK primary care. We identified patients newly prescribed fourth-line anti-hypertensive drugs (aldosterone antagonist , beta-blocker, or alpha-blocker). Using propensity score–adjusted Cox proportional hazards models, we compared the incidence of the primary outcome (composite of all-cause mortality, stroke, and myocardial infarction) between patients on different fourth-line drugs. AA was the reference drug in all comparisons. Secondary outcomes were individual components of the primary outcome, blood pressure changes, and heart failure. We used a negative control outcome, Herpes Zoster, to detect unmeasured confounding. Results Overall, 8639 patients were included. In propensity score–adjusted analyses, the hazard ratio for the primary outcome was 0.81 (95% CI, 0.55-1.19) for beta-blockers and 0.68 (95% CI, 0.46-0.96) for alpha-blockers versus AA. Findings for individual cardiovascular outcomes trended in a more plausible direction, albeit imprecise. A trend for a protective effect for Herpes Zoster across both comparisons was seen. Conclusions A higher rate of all-cause death in the AA group was likely due to unmeasured confounding in our analysis of the composite primary outcome, supported by our negative outcome analysis. Results for cardiovascular outcomes were plausible, but imprecise due to small cohort sizes and a low number of observed outcomes." @default.
• W2957790583 created "2019-07-23" @default.
• W2957790583 creator A5008535670 @default.
• W2957790583 creator A5022288501 @default.
• W2957790583 creator A5031452104 @default.
• W2957790583 creator A5069614553 @default.
• W2957790583 creator A5087393973 @default.
• W2957790583 creator A5089833703 @default.
• W2957790583 creator A5090751890 @default.
• W2957790583 date "2019-07-16" @default.
• W2957790583 modified "2023-10-17" @default.
• W2957790583 title "The comparative effectiveness of fourth‐line drugs in resistant hypertension: An application in electronic health record data" @default.
• W2957790583 cites W1492075988 @default.
• W2957790583 cites W1797367453 @default.
• W2957790583 cites W185244458 @default.
• W2957790583 cites W1976313234 @default.
• W2957790583 cites W2009428399 @default.
• W2957790583 cites W2029896549 @default.
• W2957790583 cites W2044437961 @default.
• W2957790583 cites W2051768636 @default.
• W2957790583 cites W2065974896 @default.
• W2957790583 cites W2086077933 @default.
• W2957790583 cites W2089259727 @default.
• W2957790583 cites W2099015411 @default.
• W2957790583 cites W2105092978 @default.
• W2957790583 cites W2113676816 @default.
• W2957790583 cites W2119852447 @default.
• W2957790583 cites W2122915712 @default.
• W2957790583 cites W2132086081 @default.
• W2957790583 cites W2133416234 @default.
• W2957790583 cites W2144437696 @default.
• W2957790583 cites W2155965977 @default.
• W2957790583 cites W2156249907 @default.
• W2957790583 cites W2163589808 @default.
• W2957790583 cites W2198866495 @default.
• W2957790583 cites W2509191638 @default.
• W2957790583 cites W2557139937 @default.
• W2957790583 cites W2572331255 @default.
• W2957790583 cites W2749709425 @default.
• W2957790583 cites W2758317535 @default.
• W2957790583 cites W2886144609 @default.
• W2957790583 cites W3143437408 @default.
• W2957790583 cites W4252553827 @default.
• W2957790583 doi "https://doi.org/10.1002/pds.4808" @default.
• W2957790583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6771826" @default.
• W2957790583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31313390" @default.
• W2957790583 hasPublicationYear "2019" @default.
• W2957790583 type Work @default.
• W2957790583 sameAs 2957790583 @default.
• W2957790583 citedByCount "6" @default.
• W2957790583 countsByYear W29577905832020 @default.
• W2957790583 countsByYear W29577905832022 @default.
• W2957790583 countsByYear W29577905832023 @default.
• W2957790583 crossrefType "journal-article" @default.
• W2957790583 hasAuthorship W2957790583A5008535670 @default.
• W2957790583 hasAuthorship W2957790583A5022288501 @default.
• W2957790583 hasAuthorship W2957790583A5031452104 @default.
• W2957790583 hasAuthorship W2957790583A5069614553 @default.
• W2957790583 hasAuthorship W2957790583A5087393973 @default.
• W2957790583 hasAuthorship W2957790583A5089833703 @default.
• W2957790583 hasAuthorship W2957790583A5090751890 @default.
• W2957790583 hasBestOaLocation W29577905831 @default.
• W2957790583 hasConcept C126322002 @default.
• W2957790583 hasConcept C127413603 @default.
• W2957790583 hasConcept C17923572 @default.
• W2957790583 hasConcept C194828623 @default.
• W2957790583 hasConcept C195910791 @default.
• W2957790583 hasConcept C201903717 @default.
• W2957790583 hasConcept C207103383 @default.
• W2957790583 hasConcept C2780645631 @default.
• W2957790583 hasConcept C44249647 @default.
• W2957790583 hasConcept C500558357 @default.
• W2957790583 hasConcept C50382708 @default.
• W2957790583 hasConcept C71924100 @default.
• W2957790583 hasConcept C72563966 @default.
• W2957790583 hasConcept C77350462 @default.
• W2957790583 hasConcept C78519656 @default.
• W2957790583 hasConceptScore W2957790583C126322002 @default.
• W2957790583 hasConceptScore W2957790583C127413603 @default.
• W2957790583 hasConceptScore W2957790583C17923572 @default.
• W2957790583 hasConceptScore W2957790583C194828623 @default.
• W2957790583 hasConceptScore W2957790583C195910791 @default.
• W2957790583 hasConceptScore W2957790583C201903717 @default.
• W2957790583 hasConceptScore W2957790583C207103383 @default.
• W2957790583 hasConceptScore W2957790583C2780645631 @default.
• W2957790583 hasConceptScore W2957790583C44249647 @default.
• W2957790583 hasConceptScore W2957790583C500558357 @default.
• W2957790583 hasConceptScore W2957790583C50382708 @default.
• W2957790583 hasConceptScore W2957790583C71924100 @default.
• W2957790583 hasConceptScore W2957790583C72563966 @default.
• W2957790583 hasConceptScore W2957790583C77350462 @default.
• W2957790583 hasConceptScore W2957790583C78519656 @default.
• W2957790583 hasFunder F4320307773 @default.
• W2957790583 hasFunder F4320307874 @default.
• W2957790583 hasFunder F4320309229 @default.
• W2957790583 hasFunder F4320319992 @default.
• W2957790583 hasFunder F4320320065 @default.
• W2957790583 hasFunder F4320324195 @default.

• next