FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2957896253> ?p ?o ?g. }

• W2957896253 endingPage "116643" @default.
• W2957896253 startingPage "116643" @default.
• W2957896253 abstract "Increased plasma soluble endoglin concentrations (sEng) are frequently detected in metabolic disorders accompanied with hypercholesterolemia in serum, but effect of sEng on the cholesterol biochemistry is unknown. Cholesterol and bile acids (BA) are important products of liver metabolism with numerous functions within the organism. Turnover of these substances requires precise regulation due to potential toxicities during their cumulation. In this study, we hypothesized that high sEng levels affect cholesterol homeostasis and BA turnover in mice liver.Nine-month-old transgenic male mice overexpressing human sEng and wild-type mice underwent plasma, bile, stool, and organ samples analysis by analytical, qRT-PCT and Western blot methods.sEng mice demonstrated decreased plasma total and LDL cholesterol concentrations due to upregulation of hepatic Sr-b1 and Ldlr receptors, increased liver cholesterol content, and increased Abcg8-mediated cholesterol efflux into bile. sEng also increased conversion of cholesterol into bile acids (BA) via upregulation of Cyp7a1 and increased Mdr1 expression. Plasma concentrations of BA were increased in sEng mice due to their enhanced reabsorption via ileum. Increased hepatic disposition of BA led to their increased biliary excretion coupled with choleretic activity.For the first time, we have shown that high sEng plasma levels affect cholesterol and BA homeostasis on the basis of complex liver and intestinal effects. The significance of these findings for pathophysiology of diseases associated with increased sEng concentrations remains to be elucidated in prospective studies." @default.
• W2957896253 created "2019-07-23" @default.
• W2957896253 creator A5003776730 @default.
• W2957896253 creator A5035012267 @default.
• W2957896253 creator A5040130558 @default.
• W2957896253 creator A5043886206 @default.
• W2957896253 creator A5048359497 @default.
• W2957896253 creator A5048955063 @default.
• W2957896253 creator A5055122791 @default.
• W2957896253 creator A5061548362 @default.
• W2957896253 creator A5066198193 @default.
• W2957896253 creator A5077258864 @default.
• W2957896253 creator A5082893597 @default.
• W2957896253 creator A5085440836 @default.
• W2957896253 creator A5091877325 @default.
• W2957896253 date "2019-09-01" @default.
• W2957896253 modified "2023-10-04" @default.
• W2957896253 title "High soluble endoglin levels regulate cholesterol homeostasis and bile acids turnover in the liver of transgenic mice" @default.
• W2957896253 cites W1599065434 @default.
• W2957896253 cites W1680524857 @default.
• W2957896253 cites W1880946804 @default.
• W2957896253 cites W1902605961 @default.
• W2957896253 cites W1904096699 @default.
• W2957896253 cites W1968181166 @default.
• W2957896253 cites W1983797849 @default.
• W2957896253 cites W2002121467 @default.
• W2957896253 cites W2011593158 @default.
• W2957896253 cites W2011903566 @default.
• W2957896253 cites W2022659261 @default.
• W2957896253 cites W2023854996 @default.
• W2957896253 cites W2029934114 @default.
• W2957896253 cites W2031857827 @default.
• W2957896253 cites W2038372736 @default.
• W2957896253 cites W2049767963 @default.
• W2957896253 cites W2059352674 @default.
• W2957896253 cites W2064644696 @default.
• W2957896253 cites W2065493165 @default.
• W2957896253 cites W2067876971 @default.
• W2957896253 cites W2067961925 @default.
• W2957896253 cites W2073950955 @default.
• W2957896253 cites W2081643148 @default.
• W2957896253 cites W2083422904 @default.
• W2957896253 cites W2084037262 @default.
• W2957896253 cites W2086024248 @default.
• W2957896253 cites W2087577664 @default.
• W2957896253 cites W2095025412 @default.
• W2957896253 cites W2107854517 @default.
• W2957896253 cites W2114075557 @default.
• W2957896253 cites W2116555516 @default.
• W2957896253 cites W2119121275 @default.
• W2957896253 cites W2121139264 @default.
• W2957896253 cites W2134606187 @default.
• W2957896253 cites W2136097714 @default.
• W2957896253 cites W2141282287 @default.
• W2957896253 cites W2145888094 @default.
• W2957896253 cites W2409990251 @default.
• W2957896253 cites W2413604679 @default.
• W2957896253 cites W2518511966 @default.
• W2957896253 cites W2551138522 @default.
• W2957896253 cites W2751865290 @default.
• W2957896253 cites W2765778997 @default.
• W2957896253 cites W2768221029 @default.
• W2957896253 cites W2784137104 @default.
• W2957896253 cites W2789577233 @default.
• W2957896253 cites W4247935329 @default.
• W2957896253 doi "https://doi.org/10.1016/j.lfs.2019.116643" @default.
• W2957896253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31299237" @default.
• W2957896253 hasPublicationYear "2019" @default.
• W2957896253 type Work @default.
• W2957896253 sameAs 2957896253 @default.
• W2957896253 citedByCount "9" @default.
• W2957896253 countsByYear W29578962532020 @default.
• W2957896253 countsByYear W29578962532021 @default.
• W2957896253 countsByYear W29578962532022 @default.
• W2957896253 countsByYear W29578962532023 @default.
• W2957896253 crossrefType "journal-article" @default.
• W2957896253 hasAuthorship W2957896253A5003776730 @default.
• W2957896253 hasAuthorship W2957896253A5035012267 @default.
• W2957896253 hasAuthorship W2957896253A5040130558 @default.
• W2957896253 hasAuthorship W2957896253A5043886206 @default.
• W2957896253 hasAuthorship W2957896253A5048359497 @default.
• W2957896253 hasAuthorship W2957896253A5048955063 @default.
• W2957896253 hasAuthorship W2957896253A5055122791 @default.
• W2957896253 hasAuthorship W2957896253A5061548362 @default.
• W2957896253 hasAuthorship W2957896253A5066198193 @default.
• W2957896253 hasAuthorship W2957896253A5077258864 @default.
• W2957896253 hasAuthorship W2957896253A5082893597 @default.
• W2957896253 hasAuthorship W2957896253A5085440836 @default.
• W2957896253 hasAuthorship W2957896253A5091877325 @default.
• W2957896253 hasConcept C104317684 @default.
• W2957896253 hasConcept C126322002 @default.
• W2957896253 hasConcept C127561419 @default.
• W2957896253 hasConcept C134018914 @default.
• W2957896253 hasConcept C185592680 @default.
• W2957896253 hasConcept C2778163477 @default.
• W2957896253 hasConcept C55493867 @default.
• W2957896253 hasConcept C63645605 @default.
• W2957896253 hasConcept C71924100 @default.

• next