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- W2958008042 abstract "Ribociclib has received approval in the pre/peri- and postmenopausal disease settings on the basis of the MONALEESA trials. MONALEESA-2 demonstrated that ribociclib plus letrozole significantly improved progression-free survival compared with placebo plus letrozole as first-line therapy in postmenopausal patients with HR-positive, HER2-negative advanced breast cancer. Subsequently, ongoing trials reported significant progression-free survival improvements with ribociclib in combination with either fulvestrant in postmenopausal patients with advanced breast cancer who were either treatment naive or received ≤1 line of prior endocrine therapy in the advanced disease setting (MONALEESA-3) or tamoxifen/nonsteroidal aromatase inhibitor with ovarian function suppression in pre/perimenopausal women (MONALEESA-7). This review summarizes the MONALEESA clinical program. ClinicalTrials.gov identifiers: NCT01958021 (MONALEESA-2), NCT02422615 (MONALEESA-3), NCT02278120 (MONALEESA-7)." @default.
- W2958008042 created "2019-07-23" @default.
- W2958008042 creator A5022422153 @default.
- W2958008042 date "2019-08-01" @default.
- W2958008042 modified "2023-10-17" @default.
- W2958008042 title "MONALEESA clinical program: a review of ribociclib use in different clinical settings" @default.
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- W2958008042 doi "https://doi.org/10.2217/fon-2019-0130" @default.
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