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• W2958110014 endingPage "8557" @default.
• W2958110014 startingPage "8547" @default.
• W2958110014 abstract "Helicates and related metallofoldamers, synthesised by dynamic self-assembly, represent an area of chemical space inaccessible by traditional organic synthesis, and yet with potential for discovery of new classes of drug. Here we report that water-soluble, optically pure Fe(ii)- and even Zn(ii)-based triplex metallohelices are an excellent platform for post-assembly click reactions. By these means, the in vitro anticancer activity and most importantly the selectivity of a triplex metallohelix Fe(ii) system are dramatically improved. For one compound, a remarkable array of mechanistic and pharmacological behaviours is discovered: inhibition of Na+/K+ ATPase with potency comparable to the drug ouabain, antimetastatic properties (including inhibition of cell migration, re-adhesion and invasion), cancer stem cell targeting, and finally colonosphere inhibition competitive with the drug salinomycin." @default.
• W2958110014 created "2019-07-23" @default.
• W2958110014 creator A5008663198 @default.
• W2958110014 creator A5022270941 @default.
• W2958110014 creator A5033163843 @default.
• W2958110014 creator A5034172662 @default.
• W2958110014 creator A5042872960 @default.
• W2958110014 creator A5044958025 @default.
• W2958110014 creator A5045375483 @default.
• W2958110014 creator A5056217450 @default.
• W2958110014 creator A5056753977 @default.
• W2958110014 creator A5057196333 @default.
• W2958110014 creator A5059863633 @default.
• W2958110014 creator A5081885555 @default.
• W2958110014 creator A5084467153 @default.
• W2958110014 date "2019-01-01" @default.
• W2958110014 modified "2023-09-30" @default.
• W2958110014 title "Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices<i>via</i>post-assembly modification" @default.
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