Matches in SemOpenAlex for { <https://semopenalex.org/work/W2958146825> ?p ?o ?g. }
- W2958146825 abstract "Chlamydia trachomatis ( Ct ) is the most common sexually transmitted bacterium with more than 131 million cases occurring annually worldwide. Ct infections are often asymptomatic, persisting for many years despite treatment. In vitro recovery from persistence occurs when indole is utilized by the organism’s tryptophan synthase to synthesize tryptophan, an essential amino acid for replication. Ocular but not urogenital Ct strains contain mutations in the synthase that abrogate tryptophan synthesis. Here, we discovered that the genomes of serial isolates from a woman with recurrent, treated Ct STIs over many years were identical with a novel synthase mutation. This likely allowed long-term in vivo persistence where active infection resumed only when tryptophan became available. Our findings indicate an emerging adaptive host-pathogen evolutionary strategy for survival in the urogenital tract that will prompt the field to further explore chlamydial persistence, evaluate the genetics of mutant Ct strains and fitness within the host, and their implications for disease pathogenesis." @default.
- W2958146825 created "2019-07-23" @default.
- W2958146825 creator A5003728871 @default.
- W2958146825 creator A5025567689 @default.
- W2958146825 creator A5028181302 @default.
- W2958146825 creator A5066964986 @default.
- W2958146825 creator A5086093811 @default.
- W2958146825 date "2019-08-27" @default.
- W2958146825 modified "2023-09-26" @default.
- W2958146825 title "Clinical Persistence of Chlamydia trachomatis Sexually Transmitted Strains Involves Novel Mutations in the Functional αββα Tetramer of the Tryptophan Synthase Operon" @default.
- W2958146825 cites W1533371356 @default.
- W2958146825 cites W1607931568 @default.
- W2958146825 cites W1771251144 @default.
- W2958146825 cites W1803102843 @default.
- W2958146825 cites W1827302612 @default.
- W2958146825 cites W1878895457 @default.
- W2958146825 cites W1968722509 @default.
- W2958146825 cites W1982360641 @default.
- W2958146825 cites W2000570171 @default.
- W2958146825 cites W2021141283 @default.
- W2958146825 cites W2022745880 @default.
- W2958146825 cites W2023679112 @default.
- W2958146825 cites W2024556643 @default.
- W2958146825 cites W2027541292 @default.
- W2958146825 cites W2028246523 @default.
- W2958146825 cites W2030087349 @default.
- W2958146825 cites W2031508161 @default.
- W2958146825 cites W2039104408 @default.
- W2958146825 cites W2046892081 @default.
- W2958146825 cites W2051564779 @default.
- W2958146825 cites W2052413151 @default.
- W2958146825 cites W2054304585 @default.
- W2958146825 cites W2056672240 @default.
- W2958146825 cites W2064200726 @default.
- W2958146825 cites W2065283382 @default.
- W2958146825 cites W2076498486 @default.
- W2958146825 cites W2083369434 @default.
- W2958146825 cites W2094201044 @default.
- W2958146825 cites W2094837023 @default.
- W2958146825 cites W2097072378 @default.
- W2958146825 cites W2098304796 @default.
- W2958146825 cites W2100651011 @default.
- W2958146825 cites W2117723056 @default.
- W2958146825 cites W2119835752 @default.
- W2958146825 cites W2125304134 @default.
- W2958146825 cites W2127322768 @default.
- W2958146825 cites W2127702556 @default.
- W2958146825 cites W2129133279 @default.
- W2958146825 cites W2130164757 @default.
- W2958146825 cites W2131736388 @default.
- W2958146825 cites W2132629607 @default.
- W2958146825 cites W2134153487 @default.
- W2958146825 cites W2150495063 @default.
- W2958146825 cites W2152770371 @default.
- W2958146825 cites W2153418705 @default.
- W2958146825 cites W2156350288 @default.
- W2958146825 cites W2158714788 @default.
- W2958146825 cites W2164567662 @default.
- W2958146825 cites W2167793118 @default.
- W2958146825 cites W2168770860 @default.
- W2958146825 cites W2192116738 @default.
- W2958146825 cites W2211053883 @default.
- W2958146825 cites W2312761084 @default.
- W2958146825 cites W2406165452 @default.
- W2958146825 cites W2409420382 @default.
- W2958146825 cites W2444152384 @default.
- W2958146825 cites W2558717262 @default.
- W2958146825 cites W2559191318 @default.
- W2958146825 cites W2599007783 @default.
- W2958146825 cites W2679520842 @default.
- W2958146825 cites W2761688050 @default.
- W2958146825 cites W2766653631 @default.
- W2958146825 cites W2775939306 @default.
- W2958146825 cites W2884382666 @default.
- W2958146825 cites W2898402099 @default.
- W2958146825 cites W2905195609 @default.
- W2958146825 cites W2944829287 @default.
- W2958146825 cites W3100952097 @default.
- W2958146825 cites W4240921265 @default.
- W2958146825 cites W4313344708 @default.
- W2958146825 doi "https://doi.org/10.1128/mbio.01464-19" @default.
- W2958146825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6635532" @default.
- W2958146825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31311884" @default.
- W2958146825 hasPublicationYear "2019" @default.
- W2958146825 type Work @default.
- W2958146825 sameAs 2958146825 @default.
- W2958146825 citedByCount "16" @default.
- W2958146825 countsByYear W29581468252019 @default.
- W2958146825 countsByYear W29581468252020 @default.
- W2958146825 countsByYear W29581468252021 @default.
- W2958146825 countsByYear W29581468252022 @default.
- W2958146825 countsByYear W29581468252023 @default.
- W2958146825 crossrefType "journal-article" @default.
- W2958146825 hasAuthorship W2958146825A5003728871 @default.
- W2958146825 hasAuthorship W2958146825A5025567689 @default.
- W2958146825 hasAuthorship W2958146825A5028181302 @default.
- W2958146825 hasAuthorship W2958146825A5066964986 @default.
- W2958146825 hasAuthorship W2958146825A5086093811 @default.
- W2958146825 hasBestOaLocation W29581468251 @default.
- W2958146825 hasConcept C104317684 @default.