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• W295817845 abstract "Publisher Summary This chapter examines implications of the steps in processing of mRNA for gene regulation. In bacterial cells, transcription and translation are physically intimately associated and perhaps even physiologically coupled. Evidence of the interaction between the translation and transcriptional apparatus comes from the studies of attenuation, a phenomenon where premature termination occurs in the transcription of certain operons. In eukaryotic cells, protein synthesis is structurally separated from the nuclear site of mRNA formation. The mRNA in eukaryotes is derived from primary nuclear RNA transcripts only after an elaborate set of modifications. In vertebrate cells and some insect cells, there are not only chemical modifications at both ends of the final mRNA product prior to its engagement with ribosomes in the cytoplasm but cleavage of the primary transcript and reunion of selected polynucleotide stretches—RNA:RNA splicing—is necessary to generate a functional mRNA. This chapter discusses initiation and termination in transcription units for mRNA and molarity of late transcription of Ad-2 genome. It also presents a summary of mRNA biosynthesis based on work with Ad-2 transcription units and Chinese hamster cells." @default.
• W295817845 created "2016-06-24" @default.
• W295817845 creator A5017570516 @default.
• W295817845 date "1979-01-01" @default.
• W295817845 modified "2023-10-17" @default.
• W295817845 title "STEPS IN PROCESSING OF mRNA: IMPLICATIONS FOR GENE REGULATION" @default.
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• W295817845 doi "https://doi.org/10.1016/b978-0-12-604450-8.50015-8" @default.
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