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- W2958226502 endingPage "347" @default.
- W2958226502 startingPage "347" @default.
- W2958226502 abstract "Vitamin D (VD) is a fat-soluble prohormone well known for its role in regulating calcium and phosphate metabolism. It has been clinically used for many years to prevent rickets in children, osteomalacia, and osteoporosis in adults. VD insufficiency is a common medical condition, and many supplements are available in the market in order to increase serum 25-hydroxy VD levels to recommended amounts. Over the course of the last decades, it has become increasingly clear that calcitriol, an active form of VD, regulates multiple cellular processes with effects on normal and malignant cell growth and differentiation, and on the immune and cardiovascular function. Increasing evidence supports the role of the VD system in cancer prevention and therapy. Due to many pleiotropic and beneficial effects in extra-skeletal disorders, VD has gained potential and become an interesting active for encapsulation into drug delivery systems. The purpose of this review is to present the diversity of drug delivery systems that have been reported for VD or VD derivatives in an orderly manner across the following categories: Oral administration, application on the skin, cancer prevention/therapy, and other diseases or routes of administration." @default.
- W2958226502 created "2019-07-23" @default.
- W2958226502 creator A5059090391 @default.
- W2958226502 creator A5063927486 @default.
- W2958226502 creator A5079712198 @default.
- W2958226502 date "2019-07-18" @default.
- W2958226502 modified "2023-10-10" @default.
- W2958226502 title "Drug Delivery Systems for Vitamin D Supplementation and Therapy" @default.
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- W2958226502 doi "https://doi.org/10.3390/pharmaceutics11070347" @default.
- W2958226502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6680748" @default.
- W2958226502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31323777" @default.
- W2958226502 hasPublicationYear "2019" @default.