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- W2958261737 abstract "The limitations of commercially available paracetamol formulations specifically: 1)stability and portability (commercial paracetamol suspensions) and 2) non-pediatric friendly excipients and expensive manufacturing processes (commercially available paracetamol orally disintegrating tablets) were addressed by developing tablets made using generally regarded as safe (GRAS) status excipients and a direct compression process. The aim of this study was to develop pediatric orally disintegrating tablets of paracetamol. Pediatric orally disintegrating tablets with60-mg and 120-mg paracetamol strengths which disintegrated in less than 30 seconds were successfully prepared by a simple cost effective direct compressionprocess. Tablet disintegration rates were found to correlate well with tablet waterabsorption ratios and to a lesser extent with tablet wetting times. There was nocorrelation between tablet disintegration times and tablet mechanical and physicalproperties such as the tablet breaking force (hardness) or friability.Keywords: Pediatric formulations, orally disintegrating tablets, paracetamol, drug delivery" @default.
- W2958261737 created "2019-07-23" @default.
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- W2958261737 date "2019-05-10" @default.
- W2958261737 modified "2023-09-26" @default.
- W2958261737 title "Development and evaluation of pediatric orally disintegrating paracetamol tablets" @default.
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