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- W2958324002 abstract "Chlorpyrifos is one of the most commonly used organophosphorus insecticide. Many studies showed a relationship between pesticide exposure and occurrence of diabetes. The aim was to assess toxic effect of chloropyrifos on pancrease, its ability to induce diabetes mellitus in adult male rats and evaluate whether this toxic insult is permanent or temporary. Material and methods: 24 adult male albino rats were classified into four groups. Group I: negative control. Group II: positive control gavaged orally with 0.5 ml of corn oil once a day for 8 weeks. Group III: gavaged orally with chlorpyrifos dissolved in corn oil (6.75 mg/Kg b.w /day) for 8 weeks. Group IV: orally gavaged with chlorpyrifos by the same dose as group III for 8 weeks, then left without treatment for another 4 weeks. At the end of the study, body weight of all rats were measured then blood samples were taken from all rats to estimate serum levels of amylase, lipase, glucose, insulin, reduced glutathione (GSH) and malondialdehyde (MDA) levels. Then the pancreatic tissues were dissected and submitted to histopathological and ultra-structural examination. Results: chloropyrifos administration caused significant increases in serum amylase, lipase, glucose and MDA with also significant decreament in serum insulin and GSH. These biochemical changes were associated with hisopathological changes. Stoppage of exposure for 4 weeks caused partial to complete improvement. Conclusion: chloropyrifos had toxic effects on pancrease and was considered as a risk factor for diabetes mellitus and improvement could occur after stoppage of its exposure for a period." @default.
- W2958324002 created "2019-07-23" @default.
- W2958324002 creator A5026502680 @default.
- W2958324002 creator A5062089989 @default.
- W2958324002 date "2019-07-01" @default.
- W2958324002 modified "2023-09-27" @default.
- W2958324002 title "Evaluating Chloropyrifos Induced Diabtes Mellitus, Pancreatic Toxic Effects in Adult Albino Rats and Whether This Insult Is Permanent or Temporary" @default.
- W2958324002 cites W1503393361 @default.
- W2958324002 cites W1575245978 @default.
- W2958324002 cites W1604633786 @default.
- W2958324002 cites W16572607 @default.
- W2958324002 cites W1810387001 @default.
- W2958324002 cites W1862557020 @default.
- W2958324002 cites W1912331802 @default.
- W2958324002 cites W1967451252 @default.
- W2958324002 cites W1969374006 @default.
- W2958324002 cites W1972970085 @default.
- W2958324002 cites W1977582803 @default.
- W2958324002 cites W1979613303 @default.
- W2958324002 cites W1990089345 @default.
- W2958324002 cites W1995986855 @default.
- W2958324002 cites W2004391012 @default.
- W2958324002 cites W2005588684 @default.
- W2958324002 cites W2008346372 @default.
- W2958324002 cites W2009395778 @default.
- W2958324002 cites W2010869445 @default.
- W2958324002 cites W2035745394 @default.
- W2958324002 cites W2041409896 @default.
- W2958324002 cites W2042720508 @default.
- W2958324002 cites W2044114699 @default.
- W2958324002 cites W2045227229 @default.
- W2958324002 cites W2046699151 @default.
- W2958324002 cites W2050579843 @default.
- W2958324002 cites W2050686975 @default.
- W2958324002 cites W2054075983 @default.
- W2958324002 cites W2060055730 @default.
- W2958324002 cites W2063473837 @default.
- W2958324002 cites W2073848555 @default.
- W2958324002 cites W2080700268 @default.
- W2958324002 cites W2085030960 @default.
- W2958324002 cites W2086464883 @default.
- W2958324002 cites W2086667809 @default.
- W2958324002 cites W2087953841 @default.
- W2958324002 cites W2090582566 @default.
- W2958324002 cites W2091362651 @default.
- W2958324002 cites W2094899987 @default.
- W2958324002 cites W2094925432 @default.
- W2958324002 cites W2096853440 @default.
- W2958324002 cites W2097927965 @default.
- W2958324002 cites W2107650551 @default.
- W2958324002 cites W2108462699 @default.
- W2958324002 cites W2121866743 @default.
- W2958324002 cites W2128856576 @default.
- W2958324002 cites W2138220389 @default.
- W2958324002 cites W2139933861 @default.
- W2958324002 cites W2140992272 @default.
- W2958324002 cites W2147551533 @default.
- W2958324002 cites W2147635153 @default.
- W2958324002 cites W2150833698 @default.
- W2958324002 cites W2150934151 @default.
- W2958324002 cites W2151155254 @default.
- W2958324002 cites W2160341367 @default.
- W2958324002 cites W2160953928 @default.
- W2958324002 cites W2164204589 @default.
- W2958324002 cites W2166021966 @default.
- W2958324002 cites W2167580473 @default.
- W2958324002 cites W2167793350 @default.
- W2958324002 cites W2170445501 @default.
- W2958324002 cites W2171122751 @default.
- W2958324002 cites W2181630217 @default.
- W2958324002 cites W2183661014 @default.
- W2958324002 cites W2266929960 @default.
- W2958324002 cites W2318642889 @default.
- W2958324002 cites W2320813802 @default.
- W2958324002 cites W2326693843 @default.
- W2958324002 cites W2402392610 @default.
- W2958324002 cites W2415266601 @default.
- W2958324002 cites W2518130711 @default.
- W2958324002 cites W2672419724 @default.
- W2958324002 cites W2766923130 @default.
- W2958324002 cites W2775250299 @default.
- W2958324002 cites W2782007019 @default.
- W2958324002 cites W2795155446 @default.
- W2958324002 cites W2902513612 @default.
- W2958324002 cites W2919487097 @default.
- W2958324002 cites W2946321688 @default.
- W2958324002 cites W2992125902 @default.
- W2958324002 cites W3117213737 @default.
- W2958324002 cites W3148308327 @default.
- W2958324002 cites W57738390 @default.
- W2958324002 cites W2341028645 @default.
- W2958324002 cites W3196042878 @default.
- W2958324002 doi "https://doi.org/10.21608/ajfm.2019.41229" @default.
- W2958324002 hasPublicationYear "2019" @default.
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