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- W2958363006 abstract "Human cytomegalovirus (hCMV) is considered to be the highest priority for vaccine development. This view is underscored by the significant morbidity associated with congenital hCMV infection and viraemia in transplant patients. Although a number of vaccines have been trialed, none have been licensed. The hCMV vaccine candidate that has performed best in clinical trials to date is the recombinant glycoprotein B (gB) vaccine that has demonstrated protection, ranging from a 43% to 50% efficacy in three independent phase II trials. In this review, we focus on data from the phase II trial performed in solid organ transplant patients and the outcomes of follow-up studies attempting to identify immunological and mechanistic correlates of protection associated with this vaccine strategy. We relate this to other vaccine studies of gB as well as other vaccine strategies to determine areas of commonality and divergence. Finally, through the review, we discuss the unique challenges and opportunities presented with vaccine studies in transplant populations with recommendations that could empower subsequent trials." @default.
- W2958363006 created "2019-07-23" @default.
- W2958363006 creator A5027717859 @default.
- W2958363006 creator A5067733081 @default.
- W2958363006 creator A5084236065 @default.
- W2958363006 date "2019-07-17" @default.
- W2958363006 modified "2023-10-16" @default.
- W2958363006 title "The Humoral Immune Response Against the gB Vaccine: Lessons Learnt from Protection in Solid Organ Transplantation" @default.
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- W2958363006 doi "https://doi.org/10.3390/vaccines7030067" @default.
- W2958363006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6789498" @default.
- W2958363006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31319553" @default.
- W2958363006 hasPublicationYear "2019" @default.
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