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- W2958472034 endingPage "111538" @default.
- W2958472034 startingPage "111538" @default.
- W2958472034 abstract "Cellulose nanocrystals (CNCs) have recently gained an increasing interest in nanomedicine. The production of CNCs from Ferula gummosa (Fg) by acid hydrolysis are a potential source for nano-medical applications. It has been affirmed by the performed Fourier transform infrared spectroscopy (FTIR) and x-ray diffraction (XRD) analysis that in the course of chemical treatment, the non-cellulosic components have been gradually eradicated, while the final achieved materials had been comprised of cellulose. A strong increase has been perceived in the crystallinity subsequent to performing the hydrolysis and bleaching treatments. In regards to thermal stability, the obtained CNCs have displayed a remarkable sign of high thermal stability. The field emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM) has been found that the CNCs have contained a spherical shape at the nano-scale. In the case of cell viability, the MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolium bromide) assay has not revealed any noticeable cytotoxic effect against the A549 cells. The CNCs have been labeled through the utilization of Tc-99m and have confirmed the stability of radiolabeled CNCs at room temperature for different times. The labeling efficiency has been observed to be more than 97%. Biodistribution profile and imaging have verified that the accumulation of 99mTc-CNCs has been higher in kidneys and had been circulating in the blood. The results indicated that it is possible to convert a low-cost byproduct such as roots plants into a valuable material such as cellulose nanocrystals, which are known as promising candidates to be applied for bioimaging and diagnostic." @default.
- W2958472034 created "2019-07-23" @default.
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- W2958472034 date "2019-11-01" @default.
- W2958472034 modified "2023-10-01" @default.
- W2958472034 title "Production of new cellulose nanocrystals from Ferula gummosa and their use in medical applications via investigation of their biodistribution" @default.
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- W2958472034 doi "https://doi.org/10.1016/j.indcrop.2019.111538" @default.
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