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• W2958570257 abstract "Spontaneous control of human immunodeficiency virus (HIV) is generally associated with an enhanced capacity of CD8+ T cells to eliminate infected CD4+ T cells, but the molecular characteristics of these highly functional CD8+ T cells are largely unknown. In the present study, using single-cell analysis, it was shown that HIV-specific, central memory CD8+ T cells from spontaneous HIV controllers (HICs) and antiretrovirally treated non-controllers have opposing transcriptomic profiles. Genes linked to effector functions and survival are upregulated in cells from HICs. In contrast, genes associated with activation, exhaustion and glycolysis are upregulated in cells from non-controllers. It was shown that HIV-specific CD8+ T cells from non-controllers are largely glucose dependent, whereas those from HICs have more diverse metabolic resources that enhance both their survival potential and their capacity to develop anti-HIV effector functions. The functional efficiency of the HIV-specific CD8+ T cell response in HICs is thus engraved in their memory population and related to their metabolic programme. Metabolic reprogramming in vitro through interleukin-15 treatment abrogated the glucose dependency and enhanced the antiviral potency of HIV-specific CD8+ T cells from non-controllers. Spontaneous control of HIV is linked to the ability of CD8+ T cells to eliminate infected CD4+ T cells. Here, the authors uncover metabolic differences between HIV-specific, central memory CD8+ T cells from spontaneous HIV controllers and antiretrovirally treated non-controllers, and show that in vitro metabolic reprogramming enhances the antiviral response in non-controllers cells." @default.
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• W2958570257 date "2019-07-12" @default.
• W2958570257 modified "2023-10-18" @default.
• W2958570257 title "Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection" @default.
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• W2958570257 doi "https://doi.org/10.1038/s42255-019-0081-4" @default.
• W2958570257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32694646" @default.
• W2958570257 hasPublicationYear "2019" @default.
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