Matches in SemOpenAlex for { <https://semopenalex.org/work/W2958596585> ?p ?o ?g. }
- W2958596585 endingPage "1217" @default.
- W2958596585 startingPage "1208" @default.
- W2958596585 abstract "Abstract The CD4Cre transgenic model has been widely used for T cell–specific gene manipulation. We report unexpected highly efficient Cre-mediated recombination in alveolar macrophages (AMFs), bronchial epithelial cells (BECs), and alveolar epithelial cells (AECs) in this strain of mice. Different from CD4 T cells, AMFs, AECs, and BECs do not express detectable Cre protein, suggesting that Cre protein is either very transiently expressed in these cells or only expressed in their precursors. Mice carrying a conditional constitutively active KRas (caKRas) allele and the CD4Cre transgene contain not only hyperactivated T cells but also develop severe AMF accumulation, AEC and BEC hyperplasia, and adenomas in the lung, leading to early lethality correlated with caKRas expression in these cells. We propose that caKRas–CD4Cre mice represent, to our knowledge, a novel model of proliferative pneumonitis involving macrophages and epithelial cells and that the CD4Cre model may offer unique usefulness for studying gene functions simultaneously in multilineages in the lung. Our observations, additionally, suggest that caution in data interpretation is warranted when using the CD4Cre transgenic model for T cell–specific gene manipulation, particularly when lung pathophysiological status is being examined." @default.
- W2958596585 created "2019-07-23" @default.
- W2958596585 creator A5011304020 @default.
- W2958596585 creator A5013049965 @default.
- W2958596585 creator A5018426593 @default.
- W2958596585 creator A5029507027 @default.
- W2958596585 creator A5043900381 @default.
- W2958596585 creator A5047235136 @default.
- W2958596585 creator A5059410994 @default.
- W2958596585 creator A5060356324 @default.
- W2958596585 creator A5080631544 @default.
- W2958596585 creator A5084958505 @default.
- W2958596585 creator A5090626024 @default.
- W2958596585 date "2019-09-01" @default.
- W2958596585 modified "2023-09-25" @default.
- W2958596585 title "Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis" @default.
- W2958596585 cites W100848711 @default.
- W2958596585 cites W1544291870 @default.
- W2958596585 cites W1826726928 @default.
- W2958596585 cites W1920982543 @default.
- W2958596585 cites W1921504732 @default.
- W2958596585 cites W1962783655 @default.
- W2958596585 cites W1963713163 @default.
- W2958596585 cites W1970876784 @default.
- W2958596585 cites W1970929493 @default.
- W2958596585 cites W1983237268 @default.
- W2958596585 cites W1987727742 @default.
- W2958596585 cites W1989476960 @default.
- W2958596585 cites W1994772304 @default.
- W2958596585 cites W1995872633 @default.
- W2958596585 cites W2002440150 @default.
- W2958596585 cites W2003944281 @default.
- W2958596585 cites W2007398309 @default.
- W2958596585 cites W2009101746 @default.
- W2958596585 cites W2019968246 @default.
- W2958596585 cites W2029149519 @default.
- W2958596585 cites W2029764427 @default.
- W2958596585 cites W2029878978 @default.
- W2958596585 cites W2032917789 @default.
- W2958596585 cites W2045500858 @default.
- W2958596585 cites W2057190561 @default.
- W2958596585 cites W2072165205 @default.
- W2958596585 cites W2073038315 @default.
- W2958596585 cites W2083695927 @default.
- W2958596585 cites W2085213883 @default.
- W2958596585 cites W2093230148 @default.
- W2958596585 cites W2100646399 @default.
- W2958596585 cites W2104135721 @default.
- W2958596585 cites W2106610456 @default.
- W2958596585 cites W2111740348 @default.
- W2958596585 cites W2113809180 @default.
- W2958596585 cites W2115612737 @default.
- W2958596585 cites W2120579640 @default.
- W2958596585 cites W2131969570 @default.
- W2958596585 cites W2132533341 @default.
- W2958596585 cites W2139921573 @default.
- W2958596585 cites W2140599981 @default.
- W2958596585 cites W2143050295 @default.
- W2958596585 cites W2144935474 @default.
- W2958596585 cites W2146645867 @default.
- W2958596585 cites W2157023326 @default.
- W2958596585 cites W2165562009 @default.
- W2958596585 cites W2571405606 @default.
- W2958596585 cites W2689866037 @default.
- W2958596585 cites W2736034593 @default.
- W2958596585 cites W2744103874 @default.
- W2958596585 cites W2794480084 @default.
- W2958596585 cites W2896222795 @default.
- W2958596585 cites W4240398962 @default.
- W2958596585 cites W4211147462 @default.
- W2958596585 doi "https://doi.org/10.4049/jimmunol.1900566" @default.
- W2958596585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6702086" @default.
- W2958596585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31315887" @default.
- W2958596585 hasPublicationYear "2019" @default.
- W2958596585 type Work @default.
- W2958596585 sameAs 2958596585 @default.
- W2958596585 citedByCount "1" @default.
- W2958596585 countsByYear W29585965852021 @default.
- W2958596585 crossrefType "journal-article" @default.
- W2958596585 hasAuthorship W2958596585A5011304020 @default.
- W2958596585 hasAuthorship W2958596585A5013049965 @default.
- W2958596585 hasAuthorship W2958596585A5018426593 @default.
- W2958596585 hasAuthorship W2958596585A5029507027 @default.
- W2958596585 hasAuthorship W2958596585A5043900381 @default.
- W2958596585 hasAuthorship W2958596585A5047235136 @default.
- W2958596585 hasAuthorship W2958596585A5059410994 @default.
- W2958596585 hasAuthorship W2958596585A5060356324 @default.
- W2958596585 hasAuthorship W2958596585A5080631544 @default.
- W2958596585 hasAuthorship W2958596585A5084958505 @default.
- W2958596585 hasAuthorship W2958596585A5090626024 @default.
- W2958596585 hasBestOaLocation W29585965852 @default.
- W2958596585 hasConcept C102230213 @default.
- W2958596585 hasConcept C104317684 @default.
- W2958596585 hasConcept C126322002 @default.
- W2958596585 hasConcept C141035611 @default.
- W2958596585 hasConcept C142724271 @default.
- W2958596585 hasConcept C150194340 @default.
- W2958596585 hasConcept C153911025 @default.