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- W2958664531 abstract "Brain tumor stem cells (BTSCs) are a chemoresistant population that can drive tumor growth and relapse, but the lack of BTSC-specific markers prevents selective targeting that spares resident stem cells. Through a ribosome-profiling analysis of mouse neural stem cells (NSCs) and BTSCs, we find glycerol-3-phosphate dehydrogenase 1 (GPD1) expression specifically in BTSCs and not in NSCs. GPD1 expression is present in the dormant BTSC population, which is enriched at tumor borders and drives tumor relapse after chemotherapy. GPD1 inhibition prolongs survival in mouse models of glioblastoma in part through altering cellular metabolism and protein translation, compromising BTSC maintenance. Metabolomic and lipidomic analyses confirm that GPD1+ BTSCs have a profile distinct from that of NSCs, which is dependent on GPD1 expression. Similar GPD1 expression patterns and prognostic associations are observed in human gliomas. This study provides an attractive therapeutic target for treating brain tumors and new insights into mechanisms regulating BTSC dormancy." @default.
- W2958664531 created "2019-07-23" @default.
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- W2958664531 date "2019-08-01" @default.
- W2958664531 modified "2023-10-14" @default.
- W2958664531 title "GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile" @default.
- W2958664531 cites W1617495083 @default.
- W2958664531 cites W1680737488 @default.
- W2958664531 cites W1811725048 @default.
- W2958664531 cites W1963810889 @default.
- W2958664531 cites W1964906491 @default.
- W2958664531 cites W1973214775 @default.
- W2958664531 cites W1975477048 @default.
- W2958664531 cites W1980168406 @default.
- W2958664531 cites W1980714336 @default.
- W2958664531 cites W1985323012 @default.
- W2958664531 cites W1988391379 @default.
- W2958664531 cites W1992514491 @default.
- W2958664531 cites W1994901446 @default.
- W2958664531 cites W1998495289 @default.
- W2958664531 cites W2001544973 @default.
- W2958664531 cites W2001675158 @default.
- W2958664531 cites W2004878973 @default.
- W2958664531 cites W2006986876 @default.
- W2958664531 cites W2020131167 @default.
- W2958664531 cites W2023532525 @default.
- W2958664531 cites W2025955267 @default.
- W2958664531 cites W2026541878 @default.
- W2958664531 cites W2030017878 @default.
- W2958664531 cites W2031211461 @default.
- W2958664531 cites W2035904498 @default.
- W2958664531 cites W2036044314 @default.
- W2958664531 cites W2036870885 @default.
- W2958664531 cites W2042752102 @default.
- W2958664531 cites W2044300873 @default.
- W2958664531 cites W2046445536 @default.
- W2958664531 cites W2052308581 @default.
- W2958664531 cites W2058852389 @default.
- W2958664531 cites W2060551076 @default.
- W2958664531 cites W2074983857 @default.
- W2958664531 cites W2077303750 @default.
- W2958664531 cites W2078510083 @default.
- W2958664531 cites W2079487111 @default.
- W2958664531 cites W2079517684 @default.
- W2958664531 cites W2086157203 @default.
- W2958664531 cites W2090982381 @default.
- W2958664531 cites W2095293920 @default.
- W2958664531 cites W2097065948 @default.
- W2958664531 cites W2100305481 @default.
- W2958664531 cites W2102085111 @default.
- W2958664531 cites W2106670703 @default.
- W2958664531 cites W2109926670 @default.
- W2958664531 cites W2110537190 @default.
- W2958664531 cites W2110905563 @default.
- W2958664531 cites W2113942802 @default.
- W2958664531 cites W2123509170 @default.
- W2958664531 cites W2128130529 @default.
- W2958664531 cites W2129282939 @default.
- W2958664531 cites W2130410032 @default.
- W2958664531 cites W2135925682 @default.
- W2958664531 cites W2142540639 @default.
- W2958664531 cites W2151046897 @default.
- W2958664531 cites W2158217645 @default.
- W2958664531 cites W2161289668 @default.
- W2958664531 cites W2162143298 @default.
- W2958664531 cites W2169456326 @default.
- W2958664531 cites W2169472843 @default.
- W2958664531 cites W2177317049 @default.
- W2958664531 cites W2179438025 @default.
- W2958664531 cites W2313503837 @default.
- W2958664531 cites W2416834879 @default.
- W2958664531 cites W2546514099 @default.
- W2958664531 cites W2603523955 @default.
- W2958664531 cites W2738946651 @default.
- W2958664531 cites W2767683865 @default.