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• W2958741370 abstract "Abstract This study investigated temporal change of retinal nerve fiber layer (RNFL) reflectance speckle in retinas with ocular hypertensive (OHT) damage and in control retinas from untreated eyes. Experimental OHT damage to rat retinas was induced by laser photocoagulation of the trabecular meshwork. A series of 660 nm reflectance images was collected from isolated retinas at 10-sec intervals. Areas containing speckled texture were selected on nerve fiber bundles. Correlation coefficients between images with different imaging delays were calculated and plotted as a function of delay. To evaluate the temporal change of speckles, decay of correlation coefficients with time was fitted with an exponential function characterized by a time constant τ. Reflectance per unit thickness (σ) of the areas was also measured and low σ was used as a surrogate of OHT damage. Speckle phenomena occurred in the control RNFL and the RNFL with reduced σ. In the control retinas, τ and σ were nearly constant along bundles but differed significantly among bundles in the same retinas. Among the control retinas, σ was similar, whereas τ varied significantly. In the retinas with OHT damage (low σ) τ could be within, greater or lower than the range in controls. The parameters τ and σ provide independent assessment of the RNFL with OHT damage. Measurements of temporal change of RNFL reflectance speckle may offer a method for detecting functional abnormality of the RNFL." @default.
• W2958741370 created "2019-07-23" @default.
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• W2958741370 date "2019-09-01" @default.
• W2958741370 modified "2023-09-24" @default.
• W2958741370 title "Temporal change of retinal nerve fiber layer reflectance speckle in normal and hypertensive retinas" @default.
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• W2958741370 doi "https://doi.org/10.1016/j.exer.2019.107738" @default.
• W2958741370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6703932" @default.
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