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- W2958786216 endingPage "1057" @default.
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- W2958786216 abstract "The human fungal pathogen Candida albicans switches its morphology from yeast to hyphal forms. The morphological transition may render C. albicans virulent. Several signaling cascades, including those of the cyclic AMP-protein kinase A and mitogen-activated protein kinase pathways, are responsible for morphogenesis. In this study, we observed a reduction in gene transcription of ribosomal proteins during true hyphae formation. Moreover, morphogenesis-dependent decrease in ribosomal protein gene transcription was confirmed in constitutive yeast or filamentous growing strains. We consistently observed that polysome and monosome levels were decreased by hyphal stimuli through TORC1 and Sch9 kinases. Taken together, these results provide several lines of evidence to show that the Tor1-Sch9 kinase cascade, which stimulates transcription of ribosomal protein genes, exists in C. albicans. Thus, the present study revealed a novel link between ribosome biogenesis and morphogenesis in C. albicans that is mediated by Tor1 and Sch9." @default.
- W2958786216 created "2019-07-23" @default.
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- W2958786216 creator A5067712430 @default.
- W2958786216 date "2019-07-26" @default.
- W2958786216 modified "2023-09-23" @default.
- W2958786216 title "Cross‐talk between Tor1 and Sch9 regulates hyphae‐specific genes or ribosomal protein genes in a mutually exclusive manner in<i>Candida albicans</i>" @default.
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- W2958786216 doi "https://doi.org/10.1111/mmi.14346" @default.
- W2958786216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31283060" @default.
- W2958786216 hasPublicationYear "2019" @default.
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