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• W2958867655 abstract "A novel actinobacterium, Streptomyces rochei (MSA-14) was isolated from the mining sediments of Indian Rare Earth (IRE) Ltd. southwest coast of India. Secondary metabolites were extracted from S. rochei using ethyl acetate. The crude ethyl acetate extract exhibited prominent antibacterial property with wide spectral inhibitory zones (3–15 mm) having least Minimum Inhibitory Concentration (1–50 μg/ml) and Minimum Bactericidal Concentration (10–100 μg/ml) against the tested bacterial pathogens. The extract evidenced remarkable antioxidant (91%) and hemolytic (45.52%) properties at 800 μg/ml. In addition, the extract recorded good cytotoxic effect against Artemia salina nauplii with the LC50 value of 106.75 μg/ml. Further, the extract was purified by normal phase silica column chromatography using step gradient solvent method. Among the column fractions, 14th fraction rendered good biomedicinal properties. The bioassay guided 14th fraction was further purified by preparative TLC. The lead compound was analysed using FT-IR and GC-MS analysis, which ascribed a prominent bioactive compound Pyrrolidine-2,4-Dione. In silico analysis on the biodegradability of Pyrrolidine-2,4-Dione using BIOWIN and ECOSAR signified that the identified bioactive compound is more plausible for the environment, eco-friendly, easily degradable within days to week under aerobic and anaerobic conditions. Also, it is non-toxic against chosen bacterial pathogens when compared with the standard antibiotic Streptomycin." @default.
• W2958867655 created "2019-07-23" @default.
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• W2958867655 date "2019-07-01" @default.
• W2958867655 modified "2023-09-27" @default.
• W2958867655 title "In vitro biomedicinal properties of Pyrrolidine-2,4-Dione derived from a novel actinobacterium Streptomyces rochei, a green approach" @default.
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• W2958867655 doi "https://doi.org/10.1016/j.bcab.2019.101244" @default.
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