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- W295887791 abstract "Increasing evidence suggesting possible brain protecting properties of barbiturates has accumulated over the past 10 to 15 years (5, 9, 10, 12, 14, 15). In 1970 OVERGAARD et al. (12) recommended the use of phenobarbitone together with hyperventilation in the early management of patients with severe head injuries. The object of treatment was to prevent or reduce brain edema. Based on the observation, that the short acting thiopental could abruptly reduce elevated intracranial pressure (ICP) during anesthesia (14), SHAPIRO et al. employed barbiturates and hypothermia to reduce increased ICP in five critically ill patients in whom unexpected neurological recoveries occurred (15). Other investigators have since confirmed, that thiopental is useful in reducing ICP in intensive care patients (5). Further results from the San Diego group concerning the ICP-reducing effect of short acting barbiturates have recently been reported (9, 10). Treatment resulted in a higher than expected rate of good quality survival, however, in addition to barbiturates, the patients were also aggressively treated with high doses of steroids and mannitol." @default.
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- W295887791 date "1983-01-01" @default.
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- W295887791 title "Does Barbiturate “Mono-Therapy” Favorably Influence Brain Survival After Traumatic Coma?" @default.
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- W295887791 doi "https://doi.org/10.1007/978-3-662-05589-2_51" @default.
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