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• W2958961855 abstract "Significance Prior to their exposure to foreign antigens, naïve T cells experience weak T cell antigen receptor (TCR) signals induced by self-antigens. These “basal” TCR signals vary in strength, which is reflected by the relative expression of markers such as CD5, Ly6C, and Nur77-GFP. Using a combination of Nur77-GFP and Ly6C, we show that the range of basal TCR signaling is broader than previously thought. A population of cells at the high end of this range experiences relatively strong basal TCR signals and attenuated responses to foreign antigen stimulation. These results suggest that T cells adapt to the strength of their basal TCR signaling, which results in heterogeneity of their functional capabilities following stimulation with foreign antigens." @default.
• W2958961855 created "2019-07-23" @default.
• W2958961855 creator A5050836076 @default.
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• W2958961855 date "2019-07-08" @default.
• W2958961855 modified "2023-09-29" @default.
• W2958961855 title "Adaptation by naïve CD4 ⁺ T cells to self-antigen–dependent TCR signaling induces functional heterogeneity and tolerance" @default.
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• W2958961855 doi "https://doi.org/10.1073/pnas.1904096116" @default.
• W2958961855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6660790" @default.
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