FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2958996554> ?p ?o ?g. }

• W2958996554 abstract "Abstract Natural killer (NK) cells have potential utility in pediatric cancer immunotherapy for their ability to lyse diverse tumor targets, lack of dependence on mutation‐associated tumor antigens, and for their relative safety demonstrated so far in clinical trials. Here, we evaluate the cytotoxic potential of expanded NK cells against a well‐characterized panel of pediatric cancer cell lines representing Ewing sarcoma, rhabdomyosarcoma, neuroblastoma, lymphoma, leukemia, and brain tumors. We correlate their sensitivity NK cell lysis with tumor phenotypic, transcriptomic, and genetic determinants, and correlate known immunogenetic determinants with donor NK cell potency. Although ligand expression on cell lines stratified according to hematologic versus nonhematologic cancer types, the sensitivity to NK cell lysis varied widely and did not correlate with cancer type, expression of individual activating or inhibitory ligands, gene‐expression clusters of NK cell ligands, disease status (newly diagnosed or relapsed), or MYCN amplification. Rather, sensitivity to NK cell–mediated lysis was associated with a novel 96‐gene cluster of predominantly carcinoma‐, apoptosis‐, and cell death–related pathways, and with functional p53 status. NK cell potency was strongly associated with activating KIR gene content, but not with KIR/KIR‐ligand mismatch. This study suggests that adoptive immunotherapy with expanded NK cells has the potential for a wide range of pediatric cancers, identifies potential biomarkers of efficacy and response, and establishes a foundation for using this cell line panel for the preclinical evaluation of immunotherapies." @default.
• W2958996554 created "2019-07-23" @default.
• W2958996554 creator A5008743452 @default.
• W2958996554 creator A5016684913 @default.
• W2958996554 creator A5019752519 @default.
• W2958996554 creator A5072440595 @default.
• W2958996554 creator A5075833013 @default.
• W2958996554 creator A5079667573 @default.
• W2958996554 creator A5081965912 @default.
• W2958996554 date "2019-07-15" @default.
• W2958996554 modified "2023-10-06" @default.
• W2958996554 title "Expression of carcinoma, apoptosis, and cell‐death–related genes are determinants for sensitivity of pediatric cancer cell lines to lysis by natural killer cells" @default.
• W2958996554 cites W1224709979 @default.
• W2958996554 cites W1558704041 @default.
• W2958996554 cites W1571073982 @default.
• W2958996554 cites W166987468 @default.
• W2958996554 cites W1814553093 @default.
• W2958996554 cites W1970264918 @default.
• W2958996554 cites W1978073487 @default.
• W2958996554 cites W1980021547 @default.
• W2958996554 cites W1984515197 @default.
• W2958996554 cites W2001379878 @default.
• W2958996554 cites W2003537331 @default.
• W2958996554 cites W2005765588 @default.
• W2958996554 cites W2015758016 @default.
• W2958996554 cites W2020199063 @default.
• W2958996554 cites W2020331107 @default.
• W2958996554 cites W2035826479 @default.
• W2958996554 cites W2043398720 @default.
• W2958996554 cites W2048355442 @default.
• W2958996554 cites W2062581776 @default.
• W2958996554 cites W2064800600 @default.
• W2958996554 cites W2067308312 @default.
• W2958996554 cites W2091675007 @default.
• W2958996554 cites W2107319896 @default.
• W2958996554 cites W2108493491 @default.
• W2958996554 cites W2118796952 @default.
• W2958996554 cites W2122825543 @default.
• W2958996554 cites W2123143632 @default.
• W2958996554 cites W2130011407 @default.
• W2958996554 cites W2135140338 @default.
• W2958996554 cites W2136057476 @default.
• W2958996554 cites W2144754434 @default.
• W2958996554 cites W2144872368 @default.
• W2958996554 cites W2147068163 @default.
• W2958996554 cites W2165259537 @default.
• W2958996554 cites W2165813814 @default.
• W2958996554 cites W2327552837 @default.
• W2958996554 cites W2474402643 @default.
• W2958996554 cites W2500107307 @default.
• W2958996554 cites W2518717449 @default.
• W2958996554 cites W2521461373 @default.
• W2958996554 cites W2560920541 @default.
• W2958996554 cites W2566704745 @default.
• W2958996554 cites W2567424265 @default.
• W2958996554 cites W2604387395 @default.
• W2958996554 cites W2606495925 @default.
• W2958996554 cites W2750168879 @default.
• W2958996554 cites W2775369717 @default.
• W2958996554 cites W2789869568 @default.
• W2958996554 cites W2888300718 @default.
• W2958996554 cites W4294541781 @default.
• W2958996554 cites W69353177 @default.
• W2958996554 doi "https://doi.org/10.1002/pbc.27783" @default.
• W2958996554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31304677" @default.
• W2958996554 hasPublicationYear "2019" @default.
• W2958996554 type Work @default.
• W2958996554 sameAs 2958996554 @default.
• W2958996554 citedByCount "9" @default.
• W2958996554 countsByYear W29589965542019 @default.
• W2958996554 countsByYear W29589965542021 @default.
• W2958996554 countsByYear W29589965542022 @default.
• W2958996554 countsByYear W29589965542023 @default.
• W2958996554 crossrefType "journal-article" @default.
• W2958996554 hasAuthorship W2958996554A5008743452 @default.
• W2958996554 hasAuthorship W2958996554A5016684913 @default.
• W2958996554 hasAuthorship W2958996554A5019752519 @default.
• W2958996554 hasAuthorship W2958996554A5072440595 @default.
• W2958996554 hasAuthorship W2958996554A5075833013 @default.
• W2958996554 hasAuthorship W2958996554A5079667573 @default.
• W2958996554 hasAuthorship W2958996554A5081965912 @default.
• W2958996554 hasConcept C121608353 @default.
• W2958996554 hasConcept C129374314 @default.
• W2958996554 hasConcept C154317977 @default.
• W2958996554 hasConcept C202751555 @default.
• W2958996554 hasConcept C203014093 @default.
• W2958996554 hasConcept C2776090121 @default.
• W2958996554 hasConcept C2777701055 @default.
• W2958996554 hasConcept C2778102761 @default.
• W2958996554 hasConcept C2779338263 @default.
• W2958996554 hasConcept C28651165 @default.
• W2958996554 hasConcept C502942594 @default.
• W2958996554 hasConcept C54355233 @default.
• W2958996554 hasConcept C71924100 @default.
• W2958996554 hasConcept C81885089 @default.
• W2958996554 hasConcept C86803240 @default.
• W2958996554 hasConcept C8891405 @default.
• W2958996554 hasConcept C96232424 @default.
• W2958996554 hasConceptScore W2958996554C121608353 @default.
• W2958996554 hasConceptScore W2958996554C129374314 @default.

• next