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• W2959031730 endingPage "122251" @default.
• W2959031730 startingPage "122251" @default.
• W2959031730 abstract "Mesoporous silica nanoparticles (MSNs) have been extensively applied as a promising carrier in biomedical application due to their excellent structure with tunable function. Based on the fact that the surfactant trimethoxyoctadecylsilane (C18TMS) could present different on/off states in different solvents, herein, an intelligent “on/off” switching strategy of site-specific co-loading MnOx and Ce6 into MSNs was proposed for the first time. The multifunctional theranostic nanoplatform, i.e., Ce6/MnOx@HMSNs-PEG (CMHP), shows a sensitive longitudinal relaxation signal to the over-expressed hydrogen peroxide (H2O2) and weak acidic pH in the tumor microenvironment (TME). Furthermore, MnOx component could react with H2O2 in TME to generate O2, which enable to relieve tumorous hypoxia and afterwards accelerate the generation of singlet oxygen (1O2) upon laser irradiation when combined with Ce6. Both in vitro and in vivo results confirm that this constructed nanosystem can be applied to MRI-guided sufficient photodynamic therapy (PDT) with reduced side-effects." @default.
• W2959031730 created "2019-07-23" @default.
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• W2959031730 date "2020-01-01" @default.
• W2959031730 modified "2023-10-11" @default.
• W2959031730 title "Confined nanoparticles growth within hollow mesoporous nanoreactors for highly efficient MRI-guided photodynamic therapy" @default.
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• W2959031730 doi "https://doi.org/10.1016/j.cej.2019.122251" @default.
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