FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959081801> ?p ?o ?g. }

• W2959081801 endingPage "35" @default.
• W2959081801 startingPage "29" @default.
• W2959081801 abstract "Thrombotic thrombocytopenic purpura (TTP) is a rare life threatening thrombotic microangiopathy caused by a severe functional deficiency of ADAMTS13, most frequently due to autoantibodies to ADAMTS13, thus termed acquired autoimmune TTP. ADAMTS13 specifically regulates the adhesive activity of von Willebrand factor (VWF) by cleaving its high-molecular-weight multimers (HMWM). We investigated whether VWF-HMWM level at acute phase of TTP could be a predictive factor for morbidity.We gathered clinical and biological data from a cohort of 114 patients with acquired TTP at acute phase. VWF-HMWM were assessed by electrophoretic analysis and by an ELISA measuring the capacity of VWF to bind to collagen (VWF:CB), and linear correlation between these two methods was carried out. We cross-referenced clinical and biological data with VWF-HMWM levels.VWF-HMWM levels were heterogeneous, but half of our patients were below normal range (50% if assessed by electrophoresis; 47.4% if assessed by ELISA). The correlation study between electrophoresis and ELISA reached statistical significance (r2 = 0.5979; p < 0.0001). Statistical analysis showed that loss of VWF-HMWM as assessed by VWF:CB < 70 IU/dL is associated with detectable anti-ADAMTS13 antibodies, severe neurological symptoms and thrombocytopenia (p < 0.05).Our results confirm that VWF-HMWM can be satisfactorily assessed by VWF:CB, much easier to perform than electrophoresis. The association highlighted between loss of VWF-HMWM, detectable anti-ADAMTS13 IgG and neurological symptoms may offer new insights to understanding the pathophysiology of acquired auto-immune TTP." @default.
• W2959081801 created "2019-07-23" @default.
• W2959081801 creator A5014357716 @default.
• W2959081801 creator A5014845281 @default.
• W2959081801 creator A5019469330 @default.
• W2959081801 creator A5037817902 @default.
• W2959081801 creator A5041549015 @default.
• W2959081801 creator A5068540655 @default.
• W2959081801 creator A5087152475 @default.
• W2959081801 creator A5090368572 @default.
• W2959081801 date "2019-09-01" @default.
• W2959081801 modified "2023-10-01" @default.
• W2959081801 title "Loss of von Willebrand factor high-molecular-weight multimers at acute phase is associated with detectable anti-ADAMTS13 IgG and neurological symptoms in acquired thrombotic thrombocytopenic purpura" @default.
• W2959081801 cites W1972710571 @default.
• W2959081801 cites W1990942416 @default.
• W2959081801 cites W2020077683 @default.
• W2959081801 cites W2030337128 @default.
• W2959081801 cites W2032439424 @default.
• W2959081801 cites W2039098715 @default.
• W2959081801 cites W2041065426 @default.
• W2959081801 cites W2093312854 @default.
• W2959081801 cites W2114604545 @default.
• W2959081801 cites W2122536819 @default.
• W2959081801 cites W2131111546 @default.
• W2959081801 cites W2140493963 @default.
• W2959081801 cites W2315229770 @default.
• W2959081801 cites W2336918217 @default.
• W2959081801 cites W2340760838 @default.
• W2959081801 cites W2340762935 @default.
• W2959081801 cites W2523154638 @default.
• W2959081801 cites W2605728624 @default.
• W2959081801 doi "https://doi.org/10.1016/j.thromres.2019.07.012" @default.
• W2959081801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31330376" @default.
• W2959081801 hasPublicationYear "2019" @default.
• W2959081801 type Work @default.
• W2959081801 sameAs 2959081801 @default.
• W2959081801 citedByCount "5" @default.
• W2959081801 countsByYear W29590818012020 @default.
• W2959081801 countsByYear W29590818012021 @default.
• W2959081801 countsByYear W29590818012022 @default.
• W2959081801 countsByYear W29590818012023 @default.
• W2959081801 crossrefType "journal-article" @default.
• W2959081801 hasAuthorship W2959081801A5014357716 @default.
• W2959081801 hasAuthorship W2959081801A5014845281 @default.
• W2959081801 hasAuthorship W2959081801A5019469330 @default.
• W2959081801 hasAuthorship W2959081801A5037817902 @default.
• W2959081801 hasAuthorship W2959081801A5041549015 @default.
• W2959081801 hasAuthorship W2959081801A5068540655 @default.
• W2959081801 hasAuthorship W2959081801A5087152475 @default.
• W2959081801 hasAuthorship W2959081801A5090368572 @default.
• W2959081801 hasBestOaLocation W29590818011 @default.
• W2959081801 hasConcept C10162356 @default.
• W2959081801 hasConcept C126322002 @default.
• W2959081801 hasConcept C134018914 @default.
• W2959081801 hasConcept C159654299 @default.
• W2959081801 hasConcept C163764329 @default.
• W2959081801 hasConcept C203014093 @default.
• W2959081801 hasConcept C2776513394 @default.
• W2959081801 hasConcept C2777878052 @default.
• W2959081801 hasConcept C2778585876 @default.
• W2959081801 hasConcept C2779134260 @default.
• W2959081801 hasConcept C2779394231 @default.
• W2959081801 hasConcept C2780921031 @default.
• W2959081801 hasConcept C555293320 @default.
• W2959081801 hasConcept C71924100 @default.
• W2959081801 hasConcept C89560881 @default.
• W2959081801 hasConcept C90924648 @default.
• W2959081801 hasConceptScore W2959081801C10162356 @default.
• W2959081801 hasConceptScore W2959081801C126322002 @default.
• W2959081801 hasConceptScore W2959081801C134018914 @default.
• W2959081801 hasConceptScore W2959081801C159654299 @default.
• W2959081801 hasConceptScore W2959081801C163764329 @default.
• W2959081801 hasConceptScore W2959081801C203014093 @default.
• W2959081801 hasConceptScore W2959081801C2776513394 @default.
• W2959081801 hasConceptScore W2959081801C2777878052 @default.
• W2959081801 hasConceptScore W2959081801C2778585876 @default.
• W2959081801 hasConceptScore W2959081801C2779134260 @default.
• W2959081801 hasConceptScore W2959081801C2779394231 @default.
• W2959081801 hasConceptScore W2959081801C2780921031 @default.
• W2959081801 hasConceptScore W2959081801C555293320 @default.
• W2959081801 hasConceptScore W2959081801C71924100 @default.
• W2959081801 hasConceptScore W2959081801C89560881 @default.
• W2959081801 hasConceptScore W2959081801C90924648 @default.
• W2959081801 hasFunder F4320321445 @default.
• W2959081801 hasLocation W29590818011 @default.
• W2959081801 hasLocation W29590818012 @default.
• W2959081801 hasLocation W29590818013 @default.
• W2959081801 hasLocation W29590818014 @default.
• W2959081801 hasLocation W29590818015 @default.
• W2959081801 hasLocation W29590818016 @default.
• W2959081801 hasOpenAccess W2959081801 @default.
• W2959081801 hasPrimaryLocation W29590818011 @default.
• W2959081801 hasRelatedWork W1967194398 @default.
• W2959081801 hasRelatedWork W2075323718 @default.
• W2959081801 hasRelatedWork W2084620947 @default.
• W2959081801 hasRelatedWork W2158730091 @default.
• W2959081801 hasRelatedWork W2796128753 @default.
• W2959081801 hasRelatedWork W2897799986 @default.

• next