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• W2959092261 abstract "Classical and non-classical monocytes, and the macrophages and monocyte-derived dendritic cells they produce, play key roles in host defense against pathogens, immune regulation, tissue repair and many other processes throughout the body. Recent studies have revealed previously unappreciated heterogeneity among monocytes that may explain this functional diversity, but our understanding of mechanisms controlling the functional programming of distinct monocyte subsets remains incomplete. Resolving monocyte heterogeneity and understanding how their functional identity is determined holds great promise for therapeutic immune modulation. In this review, we examine how monocyte origins and developmental influences shape the phenotypic and functional characteristics of monocyte subsets during homeostasis and in the context of infection, inflammation, and cancer. We consider how extrinsic signals and transcriptional regulators impact monocyte production and functional programming, as well as the influence of epigenetic and metabolic mechanisms. We also examine the evidence that functionally distinct monocyte subsets are produced via different developmental pathways during homeostasis and that inflammatory stimuli differentially target progenitors during an emergency response. We highlight the need for a more comprehensive understanding of the relationship between monocyte ontogeny and heterogeneity, including multiparametric single-cell profiling and functional analyses. Studies defining mechanisms of monocyte subset production and maintenance of unique monocyte identities have the potential to facilitate the design of therapeutic interventions to target specific monocyte subsets in a variety of disease contexts, including infectious and inflammatory diseases, cancer, and aging." @default.
• W2959092261 created "2019-07-23" @default.
• W2959092261 creator A5042050280 @default.
• W2959092261 creator A5042417204 @default.
• W2959092261 creator A5083595207 @default.
• W2959092261 creator A5084668010 @default.
• W2959092261 date "2019-07-17" @default.
• W2959092261 modified "2023-10-17" @default.
• W2959092261 title "The Ontogeny of Monocyte Subsets" @default.
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• W2959092261 doi "https://doi.org/10.3389/fimmu.2019.01642" @default.
• W2959092261 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6650567" @default.
• W2959092261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31379841" @default.
• W2959092261 hasPublicationYear "2019" @default.
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