Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959133057> ?p ?o ?g. }
- W2959133057 endingPage "19720" @default.
- W2959133057 startingPage "19712" @default.
- W2959133057 abstract "Cell transplantation has become a possible therapeutic approach in the treatment of neurodegenerative diseases of the nervous system by replacing lost cells. The current study aimed to make a comparison between the differentiation capacity of the olfactory bulb neural stem cells (OB-NSCs) and olfactory ectomesenchymal stem cells (OE-MSCs) into dopaminergic-like neurons under the inductive effect of transforming growth factor β (TGF-β). After culturing and treating with TGF-β, the differentiation capacities of both types of stem cells into dopaminergic neuron-like cells were evaluated. Quantitative real-time polymerase chain reaction analysis 3 weeks after induction demonstrated that the mRNA expression of the dopaminergic activity markers tyrosine hydroxylase (TH), dopamine transporter (DAT), paired box gene 2 (PAX2), and PAX5 in the neuron-like cells derived from OB-NSCs was significantly higher than those derived from OE-MSCs. These findings were further supported by the immunocytochemistry staining showing that the expression of the tyrosine hydroxylase, DAT, PAX2, and paired like homeodomain 3 seemed to be slightly higher in OB-NSCs compared with OE-MSCs. Despite the lower differentiation capacity of OE-MSCs, other considerations such as a noninvasive and easier harvesting process, faster proliferation attributes, longer life span, autologous transplantability, and also the easier and inexpensive cultural process of the OE-MSCs, cumulatively make these cells the more appropriate alternative in the case of autologous transplantation during the treatment process of neurodegenerative disorders like Parkinson's disease." @default.
- W2959133057 created "2019-07-23" @default.
- W2959133057 creator A5016012565 @default.
- W2959133057 creator A5025523457 @default.
- W2959133057 creator A5039715047 @default.
- W2959133057 creator A5047708579 @default.
- W2959133057 creator A5087686836 @default.
- W2959133057 creator A5087752277 @default.
- W2959133057 creator A5087848164 @default.
- W2959133057 date "2019-07-11" @default.
- W2959133057 modified "2023-10-16" @default.
- W2959133057 title "Differentiation of human olfactory system‐derived stem cells into dopaminergic neuron‐like cells: A comparison between olfactory bulb and mucosa as two sources of stem cells" @default.
- W2959133057 cites W1044532235 @default.
- W2959133057 cites W1513529766 @default.
- W2959133057 cites W1575729015 @default.
- W2959133057 cites W1606843899 @default.
- W2959133057 cites W1785301957 @default.
- W2959133057 cites W1821277924 @default.
- W2959133057 cites W1918210298 @default.
- W2959133057 cites W1965192340 @default.
- W2959133057 cites W1966476278 @default.
- W2959133057 cites W1967382412 @default.
- W2959133057 cites W1975564296 @default.
- W2959133057 cites W1989054444 @default.
- W2959133057 cites W2011779238 @default.
- W2959133057 cites W2014126877 @default.
- W2959133057 cites W2016378654 @default.
- W2959133057 cites W2023792909 @default.
- W2959133057 cites W2031764248 @default.
- W2959133057 cites W2039945427 @default.
- W2959133057 cites W2041695960 @default.
- W2959133057 cites W2042525405 @default.
- W2959133057 cites W2043366308 @default.
- W2959133057 cites W2046095052 @default.
- W2959133057 cites W2048258494 @default.
- W2959133057 cites W2053850374 @default.
- W2959133057 cites W2059929978 @default.
- W2959133057 cites W2063976149 @default.
- W2959133057 cites W2080205733 @default.
- W2959133057 cites W2104793567 @default.
- W2959133057 cites W2107890140 @default.
- W2959133057 cites W2125987139 @default.
- W2959133057 cites W2130128490 @default.
- W2959133057 cites W2131936798 @default.
- W2959133057 cites W2134789423 @default.
- W2959133057 cites W2138442302 @default.
- W2959133057 cites W2170552323 @default.
- W2959133057 cites W2284628150 @default.
- W2959133057 cites W2339938127 @default.
- W2959133057 cites W2523549099 @default.
- W2959133057 cites W2561522330 @default.
- W2959133057 cites W2581446635 @default.
- W2959133057 cites W2594759644 @default.
- W2959133057 cites W2621535682 @default.
- W2959133057 cites W2738204278 @default.
- W2959133057 cites W2766558265 @default.
- W2959133057 cites W2776637381 @default.
- W2959133057 cites W2804472795 @default.
- W2959133057 cites W2809032341 @default.
- W2959133057 cites W2905017971 @default.
- W2959133057 cites W2910869431 @default.
- W2959133057 cites W2913162255 @default.
- W2959133057 cites W2922541742 @default.
- W2959133057 cites W2972047651 @default.
- W2959133057 cites W4244311449 @default.
- W2959133057 doi "https://doi.org/10.1002/jcb.29277" @default.
- W2959133057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31297865" @default.
- W2959133057 hasPublicationYear "2019" @default.
- W2959133057 type Work @default.
- W2959133057 sameAs 2959133057 @default.
- W2959133057 citedByCount "15" @default.
- W2959133057 countsByYear W29591330572019 @default.
- W2959133057 countsByYear W29591330572020 @default.
- W2959133057 countsByYear W29591330572021 @default.
- W2959133057 countsByYear W29591330572022 @default.
- W2959133057 countsByYear W29591330572023 @default.
- W2959133057 crossrefType "journal-article" @default.
- W2959133057 hasAuthorship W2959133057A5016012565 @default.
- W2959133057 hasAuthorship W2959133057A5025523457 @default.
- W2959133057 hasAuthorship W2959133057A5039715047 @default.
- W2959133057 hasAuthorship W2959133057A5047708579 @default.
- W2959133057 hasAuthorship W2959133057A5087686836 @default.
- W2959133057 hasAuthorship W2959133057A5087752277 @default.
- W2959133057 hasAuthorship W2959133057A5087848164 @default.
- W2959133057 hasConcept C126322002 @default.
- W2959133057 hasConcept C136834591 @default.
- W2959133057 hasConcept C137183658 @default.
- W2959133057 hasConcept C159167319 @default.
- W2959133057 hasConcept C169760540 @default.
- W2959133057 hasConcept C201792869 @default.
- W2959133057 hasConcept C2778794669 @default.
- W2959133057 hasConcept C2780496858 @default.
- W2959133057 hasConcept C2781377823 @default.
- W2959133057 hasConcept C28328180 @default.
- W2959133057 hasConcept C2911091166 @default.
- W2959133057 hasConcept C513476851 @default.
- W2959133057 hasConcept C529278444 @default.
- W2959133057 hasConcept C71924100 @default.