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• W2959165274 abstract "The HIV-1 accessory protein Vpu mediates the downregulation of several host cell proteins, an activity that is critical for viral replication in vivo. As the first step in directing cell-surface proteins to internal cellular compartments, and in many cases degradation, Vpu binds a subset of its target proteins through their transmembrane domains. Each of the known targets of Vpu are synthesized in the ER, and must traverse the different membrane environments found along the secretory pathway, thus it is important to consider how membrane composition might influence the interactions between Vpu and its targets. We have used Förster resonance energy transfer (FRET) to measure the oligomerization of Vpu with the transmembrane domains of target proteins in model membranes of varying lipid composition. Our data show that both lipid bilayer thickness and acyl chain order can significantly influence monomer-oligomer equilibria within the Vpu-target system. Changes in oligomerization levels were found to be non-specific with no single Vpu-target interaction being favored under any condition. Our analysis of the influence of the membrane environment on the strength of helix-helix interactions between Vpu and its targets in vitro suggests that the strength of Vpu-target interactions in vivo will be partially dependent on the membrane environment found in specific membrane compartments." @default.
• W2959165274 created "2019-07-23" @default.
• W2959165274 creator A5022841391 @default.
• W2959165274 creator A5049789537 @default.
• W2959165274 date "2019-10-01" @default.
• W2959165274 modified "2023-09-24" @default.
• W2959165274 title "Hydrophobic matching of HIV-1 Vpu transmembrane helix-helix interactions is optimized for subcellular location" @default.
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• W2959165274 doi "https://doi.org/10.1016/j.bbamem.2019.07.010" @default.
• W2959165274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31302078" @default.
• W2959165274 hasPublicationYear "2019" @default.
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