Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959167984> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2959167984 endingPage "121" @default.
- W2959167984 startingPage "114" @default.
- W2959167984 abstract "Incorporating preservatives is now the most commonlyemployed strategy to prevent microbial deterioration of collagen.However, many preservatives are non-selective; they cannotdifferentiate the orthologs in mammalian cells from theirbiological targets in pathogens, and thus their incorporationcompromises the inherent biocompatibility of naturallyoccurring collagen. Here, we report a strategy to covalentlyanchor antibacterial agents to collagen via a thermally responsivepoly(N-isopropylacrylamide) spacer. As the spacer suddenlycollapses from an extended coil upon heating through ~30°C,bioactivity of the anchored antibacterial agents can be switchedoff, because their lateral mobility and, hence, target-siteaccessibility are restricted. Accordingly, the modified collagencan be preserved without microbial deterioration for ambientstorage condition, while imposing no cytotoxic impact uponsurrounding tissues in vivo. This thermally responsive collagenholds great potential in biomedical fields, where the collagenproducts are intended to have intimate contact with humantissues or be administered parenterally." @default.
- W2959167984 created "2019-07-23" @default.
- W2959167984 creator A5015510932 @default.
- W2959167984 creator A5028334776 @default.
- W2959167984 creator A5034403500 @default.
- W2959167984 creator A5042318647 @default.
- W2959167984 creator A5063800558 @default.
- W2959167984 creator A5072976893 @default.
- W2959167984 date "2018-01-01" @default.
- W2959167984 modified "2023-09-26" @default.
- W2959167984 title "Thermally Responsive Collagen Switching from Bactericidal for Ambient Storage Condition to Biologically Inert in Vivo" @default.
- W2959167984 cites W1947112600 @default.
- W2959167984 cites W1983157851 @default.
- W2959167984 cites W2026345992 @default.
- W2959167984 cites W2038289365 @default.
- W2959167984 cites W2078755127 @default.
- W2959167984 cites W2087223150 @default.
- W2959167984 cites W2099374212 @default.
- W2959167984 cites W2417614964 @default.
- W2959167984 cites W2766785756 @default.
- W2959167984 cites W67103691 @default.
- W2959167984 hasPublicationYear "2018" @default.
- W2959167984 type Work @default.
- W2959167984 sameAs 2959167984 @default.
- W2959167984 citedByCount "0" @default.
- W2959167984 crossrefType "journal-article" @default.
- W2959167984 hasAuthorship W2959167984A5015510932 @default.
- W2959167984 hasAuthorship W2959167984A5028334776 @default.
- W2959167984 hasAuthorship W2959167984A5034403500 @default.
- W2959167984 hasAuthorship W2959167984A5042318647 @default.
- W2959167984 hasAuthorship W2959167984A5063800558 @default.
- W2959167984 hasAuthorship W2959167984A5072976893 @default.
- W2959167984 hasConcept C12554922 @default.
- W2959167984 hasConcept C150903083 @default.
- W2959167984 hasConcept C154256306 @default.
- W2959167984 hasConcept C154317977 @default.
- W2959167984 hasConcept C171250308 @default.
- W2959167984 hasConcept C178790620 @default.
- W2959167984 hasConcept C185592680 @default.
- W2959167984 hasConcept C192562407 @default.
- W2959167984 hasConcept C202751555 @default.
- W2959167984 hasConcept C207001950 @default.
- W2959167984 hasConcept C2777230088 @default.
- W2959167984 hasConcept C2780104969 @default.
- W2959167984 hasConcept C31903555 @default.
- W2959167984 hasConcept C523546767 @default.
- W2959167984 hasConcept C54355233 @default.
- W2959167984 hasConcept C55493867 @default.
- W2959167984 hasConcept C67031304 @default.
- W2959167984 hasConcept C86803240 @default.
- W2959167984 hasConceptScore W2959167984C12554922 @default.
- W2959167984 hasConceptScore W2959167984C150903083 @default.
- W2959167984 hasConceptScore W2959167984C154256306 @default.
- W2959167984 hasConceptScore W2959167984C154317977 @default.
- W2959167984 hasConceptScore W2959167984C171250308 @default.
- W2959167984 hasConceptScore W2959167984C178790620 @default.
- W2959167984 hasConceptScore W2959167984C185592680 @default.
- W2959167984 hasConceptScore W2959167984C192562407 @default.
- W2959167984 hasConceptScore W2959167984C202751555 @default.
- W2959167984 hasConceptScore W2959167984C207001950 @default.
- W2959167984 hasConceptScore W2959167984C2777230088 @default.
- W2959167984 hasConceptScore W2959167984C2780104969 @default.
- W2959167984 hasConceptScore W2959167984C31903555 @default.
- W2959167984 hasConceptScore W2959167984C523546767 @default.
- W2959167984 hasConceptScore W2959167984C54355233 @default.
- W2959167984 hasConceptScore W2959167984C55493867 @default.
- W2959167984 hasConceptScore W2959167984C67031304 @default.
- W2959167984 hasConceptScore W2959167984C86803240 @default.
- W2959167984 hasIssue "4" @default.
- W2959167984 hasLocation W29591679841 @default.
- W2959167984 hasOpenAccess W2959167984 @default.
- W2959167984 hasPrimaryLocation W29591679841 @default.
- W2959167984 hasVolume "113" @default.
- W2959167984 isParatext "false" @default.
- W2959167984 isRetracted "false" @default.
- W2959167984 magId "2959167984" @default.
- W2959167984 workType "article" @default.