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- W2959169939 abstract "Aim: Umbilical cord blood (UCB) sourced allografts are promising interventions for tissue regeneration. As applications of these allografts and regulations governing them continue to evolve, we were prompted to identify parameters determining their quality, safety and regenerative potential. Materials & methods: Flow-cytometry, mass-spectrometry, protein multiplexing, nanoparticle tracking analysis and standard biological techniques were employed. Results: Quality attributes of a uniquely processed UCB-allograft (UCBr) were enumerated based on identity (cell viability, immunophenotyping, proteomic profiling, and quantification of relevant cytokines); safety (bioburden and microbiological screening), purity (endotoxin levels) and potency (effect of UCBr on chondrocytes and mesenchymal stem cells derived exosomes). These attributes were stable up to 24 months in cryopreserved UCBr. Conclusion: We identified a comprehensive panel of tests to establish the clinical efficacy and quality control attributes of a UCB-sourced allograft." @default.
- W2959169939 created "2019-07-23" @default.
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- W2959169939 date "2019-08-01" @default.
- W2959169939 modified "2023-09-28" @default.
- W2959169939 title "Characterization of an umbilical cord blood sourced product suitable for allogeneic applications" @default.
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- W2959169939 doi "https://doi.org/10.2217/rme-2019-0058" @default.
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