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- W2959176350 abstract "An increased risk for atherosclerosis in the elderly is associated with inflammation and increased oxidative- and lipid-mediated stress in the vascular system. At the molecular level, aging is associated with decreased activity of FOXO3a, a transcription factor centrally involved in regulating several stress resistance and lipid transport genes. Recent evidence has suggested potential benefits from phytochemicals and micronutrients in protecting against oxidative and lipid-mediated damage, but the molecular mechanisms of these actions are still unclear. Here we investigated whether the dietary polyphenol curcumin can modulate the expression and activity of FOXO3a in THP-1 cells. Curcumin induced FOXO3a phosphorylation, FOXO3a nuclear translocation, and increased FOXO3a-mediated gene expression by 2-fold, as measured using a FOXO3a-luciferase reporter gene. The curcumin derivative, tetrahydrocurcumin, which has a similar chemical antioxidant activity as curcumin, did not show any measurable effect. Curcumin also influenced the expression of FOXO3a-responsive target genes (catalase, MnSOD, aP2, CD36). Thus, up-regulating FOXO3a activity by curcumin could be a mechanism to protect against oxidant- and lipid-induced damage in the inflammatory cells of the vascular system and thus reduce the risk for cardiovascular disease in the elderly. Supported by USDA Contract #58-1950-7-707." @default.
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- W2959176350 date "2011-04-01" @default.
- W2959176350 modified "2023-09-23" @default.
- W2959176350 title "Regulatory effects of curcumin on FOXO3a in human THP‐1 monocytes/macrophages" @default.
- W2959176350 doi "https://doi.org/10.1096/fasebj.25.1_supplement.95.1" @default.
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