Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959182110> ?p ?o ?g. }
- W2959182110 endingPage "3812" @default.
- W2959182110 startingPage "3799" @default.
- W2959182110 abstract "Abstract Environmental factors early in life can have lasting influence on the development and phenotypes of animals, but the underlying molecular modifications remain poorly understood. We examined cross‐sectional associations among early life socioecological factors and global DNA methylation in 293 wild spotted hyenas ( Crocuta crocuta ) in the Masai Mara National Reserve, Kenya, grouped according to three age classes (cub, subadult and adult). Explanatory variables of interest included annual maternal rank based on outcomes of dyadic agonistic interactions, litter size, wild ungulate prey density and anthropogenic disturbance in the year each hyena was born based on counts of illegal livestock in the Reserve. The dependent variable of interest was global DNA methylation, assessed via the LUminometric Methylation Assay, which provides a percentage methylation value calculated at CCGG sites across the genome. Among cubs, we observed approximately 2.75% higher CCGG methylation in offspring born to high‐ than low‐ranking mothers. Among cubs and subadults, higher anthropogenic disturbance corresponded with greater %CCGG methylation. In both cubs and adults, we found an inverse association between prey density measured before a hyena was 3 months old and %CCGG methylation. Our results suggest that maternal rank, anthropogenic disturbance and prey availability early in life are associated with later life global DNA methylation. Future studies are required to understand the extent to which these DNA methylation patterns relate to adult phenotypes and fitness outcomes." @default.
- W2959182110 created "2019-07-23" @default.
- W2959182110 creator A5024951732 @default.
- W2959182110 creator A5040696237 @default.
- W2959182110 creator A5043134516 @default.
- W2959182110 creator A5052017902 @default.
- W2959182110 creator A5065033996 @default.
- W2959182110 creator A5066271509 @default.
- W2959182110 creator A5073554595 @default.
- W2959182110 creator A5080153412 @default.
- W2959182110 date "2019-08-01" @default.
- W2959182110 modified "2023-10-14" @default.
- W2959182110 title "Early life social and ecological determinants of global DNA methylation in wild spotted hyenas" @default.
- W2959182110 cites W1571666545 @default.
- W2959182110 cites W1912866768 @default.
- W2959182110 cites W1974747095 @default.
- W2959182110 cites W1979638914 @default.
- W2959182110 cites W1982152565 @default.
- W2959182110 cites W1984486655 @default.
- W2959182110 cites W1987109668 @default.
- W2959182110 cites W1988049214 @default.
- W2959182110 cites W1995627657 @default.
- W2959182110 cites W1997270596 @default.
- W2959182110 cites W1997866877 @default.
- W2959182110 cites W1997990636 @default.
- W2959182110 cites W2003985631 @default.
- W2959182110 cites W2007128560 @default.
- W2959182110 cites W2009396016 @default.
- W2959182110 cites W2014852291 @default.
- W2959182110 cites W2020915761 @default.
- W2959182110 cites W2023593748 @default.
- W2959182110 cites W2024439539 @default.
- W2959182110 cites W2026835968 @default.
- W2959182110 cites W2033036917 @default.
- W2959182110 cites W2033139829 @default.
- W2959182110 cites W2036731398 @default.
- W2959182110 cites W2040518110 @default.
- W2959182110 cites W2041370856 @default.
- W2959182110 cites W2041536649 @default.
- W2959182110 cites W2042334757 @default.
- W2959182110 cites W2044616072 @default.
- W2959182110 cites W2046721554 @default.
- W2959182110 cites W2049590417 @default.
- W2959182110 cites W2051330882 @default.
- W2959182110 cites W2060029387 @default.
- W2959182110 cites W2061632260 @default.
- W2959182110 cites W2062093164 @default.
- W2959182110 cites W2063135131 @default.
- W2959182110 cites W2065973763 @default.
- W2959182110 cites W2068210357 @default.
- W2959182110 cites W2068660463 @default.
- W2959182110 cites W2082678170 @default.
- W2959182110 cites W2083225704 @default.
- W2959182110 cites W2089436195 @default.
- W2959182110 cites W2091602444 @default.
- W2959182110 cites W2092363037 @default.
- W2959182110 cites W2093272186 @default.
- W2959182110 cites W2095910247 @default.
- W2959182110 cites W2106340111 @default.
- W2959182110 cites W2106344872 @default.
- W2959182110 cites W2110319588 @default.
- W2959182110 cites W2114041490 @default.
- W2959182110 cites W2114611642 @default.
- W2959182110 cites W2118995736 @default.
- W2959182110 cites W2122238028 @default.
- W2959182110 cites W2123032740 @default.
- W2959182110 cites W2130061118 @default.
- W2959182110 cites W2130189740 @default.
- W2959182110 cites W2133148874 @default.
- W2959182110 cites W2136491899 @default.
- W2959182110 cites W2136552692 @default.
- W2959182110 cites W2141469771 @default.
- W2959182110 cites W2141524808 @default.
- W2959182110 cites W2143858605 @default.
- W2959182110 cites W2148062286 @default.
- W2959182110 cites W2152497434 @default.
- W2959182110 cites W2154939617 @default.
- W2959182110 cites W2159655984 @default.
- W2959182110 cites W2165558339 @default.
- W2959182110 cites W2167015768 @default.
- W2959182110 cites W2168909179 @default.
- W2959182110 cites W2170760271 @default.
- W2959182110 cites W2217604376 @default.
- W2959182110 cites W2340642658 @default.
- W2959182110 cites W2530333661 @default.
- W2959182110 cites W2554177165 @default.
- W2959182110 cites W2575074732 @default.
- W2959182110 cites W2591052066 @default.
- W2959182110 cites W2618311580 @default.
- W2959182110 cites W2755111377 @default.
- W2959182110 cites W2766207844 @default.
- W2959182110 cites W2768124494 @default.
- W2959182110 cites W2792188131 @default.
- W2959182110 cites W2793105416 @default.
- W2959182110 cites W2793627059 @default.
- W2959182110 cites W2801024535 @default.
- W2959182110 cites W2801414913 @default.
- W2959182110 cites W2887847409 @default.