Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959252178> ?p ?o ?g. }
- W2959252178 endingPage "991" @default.
- W2959252178 startingPage "976" @default.
- W2959252178 abstract "Neuroinflammation is a major contributor to secondary neuronal injury that accounts for a significant proportion of final brain cell loss in neonatal hypoxic-ischemic encephalopathy (HIE). However, the immunological mechanisms that underlie HIE remain unclear. MicroRNA-210 (miR-210) is the master “hypoxamir” and plays a key role in hypoxic-ischemic tissue damage. Herein, we report in an animal model of neonatal rats that HIE significantly upregulated miR-210 expression in microglia in the neonatal brain and strongly induced activated microglia. Intracerebroventricular administration of miR-210 antagomir effectively suppressed microglia-mediated neuroinflammation and significantly reduced brain injury caused by HIE. We demonstrated that miR-210 induced microglial M1 activation partly by targeting SIRT1, thereby reducing the deacetylation of the NF-κB subunit p65 and increasing NF-κB signaling activity. Thus, our study identified miR-210 as a novel regulator of microglial activation in neonatal HIE, highlighting a potential therapeutic target in the treatment of infants with hypoxic-ischemic brain injury." @default.
- W2959252178 created "2019-07-23" @default.
- W2959252178 creator A5000563389 @default.
- W2959252178 creator A5010889678 @default.
- W2959252178 creator A5012427092 @default.
- W2959252178 creator A5019611836 @default.
- W2959252178 creator A5066716873 @default.
- W2959252178 date "2019-07-12" @default.
- W2959252178 modified "2023-10-17" @default.
- W2959252178 title "MiRNA-210 induces microglial activation and regulates microglia-mediated neuroinflammation in neonatal hypoxic-ischemic encephalopathy" @default.
- W2959252178 cites W144423133 @default.
- W2959252178 cites W1493890929 @default.
- W2959252178 cites W1870861092 @default.
- W2959252178 cites W1964156547 @default.
- W2959252178 cites W1964502026 @default.
- W2959252178 cites W1965942744 @default.
- W2959252178 cites W1978634992 @default.
- W2959252178 cites W1989842396 @default.
- W2959252178 cites W1997749017 @default.
- W2959252178 cites W1999292228 @default.
- W2959252178 cites W2004430093 @default.
- W2959252178 cites W2010693203 @default.
- W2959252178 cites W2011188823 @default.
- W2959252178 cites W2019070297 @default.
- W2959252178 cites W2022116223 @default.
- W2959252178 cites W2028544598 @default.
- W2959252178 cites W2032877933 @default.
- W2959252178 cites W2032893532 @default.
- W2959252178 cites W2049224825 @default.
- W2959252178 cites W2052490110 @default.
- W2959252178 cites W2053698923 @default.
- W2959252178 cites W2053715640 @default.
- W2959252178 cites W2056218807 @default.
- W2959252178 cites W2057310829 @default.
- W2959252178 cites W2071925659 @default.
- W2959252178 cites W2072384232 @default.
- W2959252178 cites W2086513198 @default.
- W2959252178 cites W2089467855 @default.
- W2959252178 cites W2091242408 @default.
- W2959252178 cites W2093878343 @default.
- W2959252178 cites W2094057765 @default.
- W2959252178 cites W2094617144 @default.
- W2959252178 cites W2098735224 @default.
- W2959252178 cites W2108388278 @default.
- W2959252178 cites W2116000203 @default.
- W2959252178 cites W2121826039 @default.
- W2959252178 cites W2124836944 @default.
- W2959252178 cites W2136862258 @default.
- W2959252178 cites W2138610504 @default.
- W2959252178 cites W2139128338 @default.
- W2959252178 cites W2140925956 @default.
- W2959252178 cites W2143516276 @default.
- W2959252178 cites W2151400960 @default.
- W2959252178 cites W2156023352 @default.
- W2959252178 cites W2160889581 @default.
- W2959252178 cites W2165682628 @default.
- W2959252178 cites W2201036738 @default.
- W2959252178 cites W2272525849 @default.
- W2959252178 cites W2336069213 @default.
- W2959252178 cites W2338020311 @default.
- W2959252178 cites W2339513854 @default.
- W2959252178 cites W2386536279 @default.
- W2959252178 cites W2467789036 @default.
- W2959252178 cites W2572710398 @default.
- W2959252178 cites W2574767639 @default.
- W2959252178 cites W2587765841 @default.
- W2959252178 cites W2689230681 @default.
- W2959252178 cites W2748302560 @default.
- W2959252178 cites W2752528166 @default.
- W2959252178 cites W2760362374 @default.
- W2959252178 cites W2763829062 @default.
- W2959252178 cites W2765662380 @default.
- W2959252178 cites W2765857420 @default.
- W2959252178 cites W2789473127 @default.
- W2959252178 cites W2799871629 @default.
- W2959252178 cites W2909091356 @default.
- W2959252178 doi "https://doi.org/10.1038/s41423-019-0257-6" @default.
- W2959252178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7608107" @default.
- W2959252178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31300734" @default.
- W2959252178 hasPublicationYear "2019" @default.
- W2959252178 type Work @default.
- W2959252178 sameAs 2959252178 @default.
- W2959252178 citedByCount "87" @default.
- W2959252178 countsByYear W29592521782019 @default.
- W2959252178 countsByYear W29592521782020 @default.
- W2959252178 countsByYear W29592521782021 @default.
- W2959252178 countsByYear W29592521782022 @default.
- W2959252178 countsByYear W29592521782023 @default.
- W2959252178 crossrefType "journal-article" @default.
- W2959252178 hasAuthorship W2959252178A5000563389 @default.
- W2959252178 hasAuthorship W2959252178A5010889678 @default.
- W2959252178 hasAuthorship W2959252178A5012427092 @default.
- W2959252178 hasAuthorship W2959252178A5019611836 @default.
- W2959252178 hasAuthorship W2959252178A5066716873 @default.
- W2959252178 hasBestOaLocation W29592521781 @default.
- W2959252178 hasConcept C104317684 @default.
- W2959252178 hasConcept C126322002 @default.
- W2959252178 hasConcept C145059251 @default.