Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959261657> ?p ?o ?g. }
- W2959261657 endingPage "707" @default.
- W2959261657 startingPage "700" @default.
- W2959261657 abstract "Efficient delivery of brain-targeted drugs is highly important for successful therapy in Parkinson’s disease (PD). This study was designed to formulate borneol and lactoferrin co-modified nanoparticles (Lf-BNPs) encapsulated dopamine as a novel drug delivery system to achieve maximum therapeutic efficacy and reduce side effects for PD. Dopamine Lf-BNPs were prepared using the double emulsion solvent evaporation method and evaluated for physicochemical and pharmaceutical properties. In vitro cytotoxicity studies indicated that treatment with dopamine Lf-BNPs has relatively low cytotoxicity in SH-SY5Y and 16HBE cells. Qualitative and quantitative cellular uptake experiments indicated that Lf modification of NPs increased cellular uptake of SH-SY5Y cells and 16HBE cells, and borneol modification can promote the cellular uptake of 16HBE. In vivo pharmacokinetic studies indicated that AUC0–12 h in the rat brain for dopamine Lf-BNPs was significantly higher (p < .05) than that of dopamine nanoparticles. Intranasal administration of dopamine Lf-BNPs effectively alleviated the 6-hydroxydopamine-induced striatum lesion in rats as indicated by the contralateral rotation behavior test and results for striatal monoamine neurotransmitter content detection. Taken together, intranasal administration of dopamine Lf-BNPs may be an effective drug delivery system for Parkinson’s disease." @default.
- W2959261657 created "2019-07-23" @default.
- W2959261657 creator A5007263180 @default.
- W2959261657 creator A5015603864 @default.
- W2959261657 creator A5020405203 @default.
- W2959261657 creator A5043116426 @default.
- W2959261657 creator A5052742303 @default.
- W2959261657 creator A5054049125 @default.
- W2959261657 creator A5062833049 @default.
- W2959261657 creator A5066233253 @default.
- W2959261657 creator A5075424710 @default.
- W2959261657 creator A5080495628 @default.
- W2959261657 creator A5085943321 @default.
- W2959261657 date "2019-01-01" @default.
- W2959261657 modified "2023-10-14" @default.
- W2959261657 title "Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease" @default.
- W2959261657 cites W1488734028 @default.
- W2959261657 cites W1556919154 @default.
- W2959261657 cites W1963835612 @default.
- W2959261657 cites W1968548727 @default.
- W2959261657 cites W1972391714 @default.
- W2959261657 cites W1974503082 @default.
- W2959261657 cites W1977332519 @default.
- W2959261657 cites W1986129921 @default.
- W2959261657 cites W1988305904 @default.
- W2959261657 cites W1992535564 @default.
- W2959261657 cites W2011964680 @default.
- W2959261657 cites W2013706809 @default.
- W2959261657 cites W2043737083 @default.
- W2959261657 cites W2047887308 @default.
- W2959261657 cites W2048811481 @default.
- W2959261657 cites W2068917179 @default.
- W2959261657 cites W2069059801 @default.
- W2959261657 cites W2074530059 @default.
- W2959261657 cites W2076294790 @default.
- W2959261657 cites W2085106089 @default.
- W2959261657 cites W2113945122 @default.
- W2959261657 cites W2157747136 @default.
- W2959261657 cites W2172960113 @default.
- W2959261657 cites W2281496323 @default.
- W2959261657 cites W2288069176 @default.
- W2959261657 cites W2380988490 @default.
- W2959261657 cites W2415859941 @default.
- W2959261657 cites W2507535671 @default.
- W2959261657 cites W2560387665 @default.
- W2959261657 cites W2587911054 @default.
- W2959261657 cites W2588725516 @default.
- W2959261657 cites W2612247067 @default.
- W2959261657 cites W2627042624 @default.
- W2959261657 cites W2735128817 @default.
- W2959261657 cites W2782771962 @default.
- W2959261657 cites W2789338523 @default.
- W2959261657 cites W2792702566 @default.
- W2959261657 cites W2792878484 @default.
- W2959261657 cites W2793150526 @default.
- W2959261657 cites W2889706401 @default.
- W2959261657 cites W2910981495 @default.
- W2959261657 cites W2914680492 @default.
- W2959261657 doi "https://doi.org/10.1080/10717544.2019.1636420" @default.
- W2959261657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7577045" @default.
- W2959261657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31290705" @default.
- W2959261657 hasPublicationYear "2019" @default.
- W2959261657 type Work @default.
- W2959261657 sameAs 2959261657 @default.
- W2959261657 citedByCount "89" @default.
- W2959261657 countsByYear W29592616572020 @default.
- W2959261657 countsByYear W29592616572021 @default.
- W2959261657 countsByYear W29592616572022 @default.
- W2959261657 countsByYear W29592616572023 @default.
- W2959261657 crossrefType "journal-article" @default.
- W2959261657 hasAuthorship W2959261657A5007263180 @default.
- W2959261657 hasAuthorship W2959261657A5015603864 @default.
- W2959261657 hasAuthorship W2959261657A5020405203 @default.
- W2959261657 hasAuthorship W2959261657A5043116426 @default.
- W2959261657 hasAuthorship W2959261657A5052742303 @default.
- W2959261657 hasAuthorship W2959261657A5054049125 @default.
- W2959261657 hasAuthorship W2959261657A5062833049 @default.
- W2959261657 hasAuthorship W2959261657A5066233253 @default.
- W2959261657 hasAuthorship W2959261657A5075424710 @default.
- W2959261657 hasAuthorship W2959261657A5080495628 @default.
- W2959261657 hasAuthorship W2959261657A5085943321 @default.
- W2959261657 hasBestOaLocation W29592616571 @default.
- W2959261657 hasConcept C134018914 @default.
- W2959261657 hasConcept C134728086 @default.
- W2959261657 hasConcept C150903083 @default.
- W2959261657 hasConcept C170493617 @default.
- W2959261657 hasConcept C185592680 @default.
- W2959261657 hasConcept C187714386 @default.
- W2959261657 hasConcept C207001950 @default.
- W2959261657 hasConcept C2775864247 @default.
- W2959261657 hasConcept C2778402981 @default.
- W2959261657 hasConcept C513476851 @default.
- W2959261657 hasConcept C529278444 @default.
- W2959261657 hasConcept C55493867 @default.
- W2959261657 hasConcept C71924100 @default.
- W2959261657 hasConcept C85663871 @default.
- W2959261657 hasConcept C86803240 @default.
- W2959261657 hasConcept C98274493 @default.