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- W2959272008 abstract "High-grade non-Hodgkin's B cells lymphomas (NHLs) are malignant tumours of the lymphoid system. MYC protein was known correlated with poor prognosis. In addition to promoting cell-cycle progression, MYC plays an important role activation of an alternative pathway of a tumour associated macrophage (TAM). We further determined if MYC protein expression correlated with the high density of TAM. This was a cross-sectional study of 47 specimens of high-grade non-Hodgkin B cell lymphomas. Their immunophenotype was re-evaluated, and stratified into DLBCL and others non-Hodgkin lymphomas. All samples were immunostained with MYC and CD163 antibodies. The expression of MYC and CD163 were scored according to the previous study. Statistical analysis was performed by using SPSS version 22. MYC positive expression was detected in 72,3% of patients. Its found mostly in male patient, age ≤60, and Ki67 >70%. Average density of TAMs was 7,29. An average density of TAM in MYC positive lymphomas was higher rather than MYC negative lymphomas. MYC may facilitate the high density of TAM and contribute to worst prognosis in younger male patient and Ki67 >70%, of high-grade B cell lymphomas." @default.
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- W2959272008 date "2019-07-01" @default.
- W2959272008 modified "2023-09-26" @default.
- W2959272008 title "Role of MYC in the tumor microenvironment in high grade non-Hodgkin B cell lymphomas" @default.
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- W2959272008 doi "https://doi.org/10.1088/1742-6596/1246/1/012026" @default.
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