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• W2959328538 endingPage "106226" @default.
• W2959328538 startingPage "106226" @default.
• W2959328538 abstract "The quaternary structures of insulin glargine and glulisine under formulation conditions and upon dilution using placebo or water were investigated using synchrotron small-angle X-ray scattering. Our results revealed that insulin glulisine in Apidra® is predominantly hexameric in solution with significant fractions of dodecamers and monomers. Upon dilution with placebo, this equilibrium shifts towards monomers. Insulin glargine in Lantus® and Toujeo® is present in a stable hexamer/dimer equilibrium, which is hardly affected by dilution with water down to 1 mg/ml insulin concentration. The results provide exclusive insight into the quaternary structure and thus the association/dissociation properties of the two insulin analogues in marketed formulations." @default.
• W2959328538 created "2019-07-23" @default.
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• W2959328538 date "2019-10-01" @default.
• W2959328538 modified "2023-09-26" @default.
• W2959328538 title "The quaternary structure of insulin glargine and glulisine under formulation conditions" @default.
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• W2959328538 doi "https://doi.org/10.1016/j.bpc.2019.106226" @default.
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