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• W2959337902 endingPage "105428" @default.
• W2959337902 startingPage "105428" @default.
• W2959337902 abstract "Early diagnosis of sepsis is often difficult in clinical practice, whilst it can be vital for positive patient outcomes in sepsis management. Any delay in diagnosis and treatment may lead to significant organ failure and can be associated with elevated mortality rates. Early diagnosis and effective management of sepsis can allow for prompt antibiotic therapy and a potential reduction in mortality; it can also minimize the unnecessary use of antibiotics. Furthermore, vitamin D supplementation, which is commonly used in the intensive care units to reduce mortality, may interfere with the ability to use procalcitonin (PCT) as a means of assessing clinical progression. This paper aims to explore the diagnostic and prognostic value of serum levels of PCT as an early marker of sepsis and to assess whether it can be used as a guide for using antibiotic therapy. Several serum-based biomarkers such as C-reactive protein, lactate, presepsin, and cytokines, such as interleukin-1 (IL-1), and IL-6 have been evaluated as early indicators of sepsis but none have been proven sensitive and/or specific enough to make a definitive diagnosis. Finally the potential benefits and disadvantages of using serum levels of PCT to diagnose and monitor patients with sepsis and septic shock will be briefly discussed." @default.
• W2959337902 created "2019-07-23" @default.
• W2959337902 creator A5010105721 @default.
• W2959337902 creator A5064977553 @default.
• W2959337902 creator A5071170614 @default.
• W2959337902 date "2019-10-01" @default.
• W2959337902 modified "2023-09-26" @default.
• W2959337902 title "Procalcitonin as a biomarker for critically ill patients with sepsis: Effects of vitamin D supplementation" @default.
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• W2959337902 doi "https://doi.org/10.1016/j.jsbmb.2019.105428" @default.
• W2959337902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31323346" @default.
• W2959337902 hasPublicationYear "2019" @default.
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