FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959366> ?p ?o ?g. }

• W2959366 endingPage "121" @default.
• W2959366 startingPage "109" @default.
• W2959366 abstract "This chapter discusses whether interventions into the germline might justify a restriction of reproductive autonomy to limit possible side effects to the treated individual. Although there is a disagreement about the assessment of human gene therapy in general, two major ethical landmarks are widely accepted; firstly, the aim of the intervention, distinguishing prevention or cure of a defined disease from enhancement, and secondly the range of the treatment. Another important fact when assessing the risk of germline modifications in somatic gene therapy is the developmental stage at the time of intervention. In utero therapies may involve a higher risk of germline modifications, which cannot sufficiently be quantified yet. Every efficient gene therapy performed during the first two weeks of individual development will equally affect both germline and soma cells. Every measure adopted for limiting individual reproductive autonomy must tend to protect the subsequent generations from harm by preventing defective gametes from being transmitted, and attempt to avoid early embryos being affected during pregnancy. Thus, before any gene-therapeutic intervention, gametes should be saved and stored, and contraception should be guaranteed as far as possible after the intervention. Gene therapy in human beings might carry severe risks for subsequent generations. The health of future offspring can be endangered by not only intended interventions in germline cells, but also by inadvertent effects of somatic gene therapy. Therefore, one should investigate whether interventions into the germline might justify a restriction of reproductive autonomy in order to limit possible side effects to the treated individual. In a first step, relevant germline interventions and their risk profile will be presented briefly. Subsequently, a definition of “reproductive autonomy” and the development of different methods for a gradual limitation of this fundamental right will enable us to discuss the legitimacy of such a restriction. By pointing out general ethical aspects and probable further developments, some considerations concerning the justification of restricting reproductive autonomy can be made. Some measures adopted so far will be illustrated, and a short summary of the actual discourse about the relevance of inadvertent germline effects will show the difficulties regarding risk assessment in this special case. It will then be suggested that, at this point, a risk-adjusted approach for restricting individual reproductive autonomy seems to be the best possible solution." @default.
• W2959366 created "2016-06-24" @default.
• W2959366 creator A5081140133 @default.
• W2959366 date "2006-01-01" @default.
• W2959366 modified "2023-09-25" @default.
• W2959366 title "Do Germline Interventions Justify the Restriction of Reproductive Autonomy?" @default.
• W2959366 cites W1549916069 @default.
• W2959366 cites W1569932862 @default.
• W2959366 cites W173160620 @default.
• W2959366 cites W1982857430 @default.
• W2959366 cites W1989868163 @default.
• W2959366 cites W1995819143 @default.
• W2959366 cites W2001723434 @default.
• W2959366 cites W2002727024 @default.
• W2959366 cites W2011251930 @default.
• W2959366 cites W2014356856 @default.
• W2959366 cites W2032727792 @default.
• W2959366 cites W2034421167 @default.
• W2959366 cites W2049109647 @default.
• W2959366 cites W2050557699 @default.
• W2959366 cites W2054861758 @default.
• W2959366 cites W2073333289 @default.
• W2959366 cites W2075765271 @default.
• W2959366 cites W2109478597 @default.
• W2959366 cites W2145457524 @default.
• W2959366 cites W2160167102 @default.
• W2959366 cites W2161013638 @default.
• W2959366 cites W4245726666 @default.
• W2959366 cites W4252780129 @default.
• W2959366 cites W80191286 @default.
• W2959366 doi "https://doi.org/10.1016/b978-044452806-3/50011-1" @default.
• W2959366 hasPublicationYear "2006" @default.
• W2959366 type Work @default.
• W2959366 sameAs 2959366 @default.
• W2959366 citedByCount "0" @default.
• W2959366 crossrefType "book-chapter" @default.
• W2959366 hasAuthorship W2959366A5081140133 @default.
• W2959366 hasConcept C104317684 @default.
• W2959366 hasConcept C109825262 @default.
• W2959366 hasConcept C118552586 @default.
• W2959366 hasConcept C17744445 @default.
• W2959366 hasConcept C199539241 @default.
• W2959366 hasConcept C27415008 @default.
• W2959366 hasConcept C2780665704 @default.
• W2959366 hasConcept C54355233 @default.
• W2959366 hasConcept C65414064 @default.
• W2959366 hasConcept C71924100 @default.
• W2959366 hasConcept C86803240 @default.
• W2959366 hasConceptScore W2959366C104317684 @default.
• W2959366 hasConceptScore W2959366C109825262 @default.
• W2959366 hasConceptScore W2959366C118552586 @default.
• W2959366 hasConceptScore W2959366C17744445 @default.
• W2959366 hasConceptScore W2959366C199539241 @default.
• W2959366 hasConceptScore W2959366C27415008 @default.
• W2959366 hasConceptScore W2959366C2780665704 @default.
• W2959366 hasConceptScore W2959366C54355233 @default.
• W2959366 hasConceptScore W2959366C65414064 @default.
• W2959366 hasConceptScore W2959366C71924100 @default.
• W2959366 hasConceptScore W2959366C86803240 @default.
• W2959366 hasLocation W29593661 @default.
• W2959366 hasOpenAccess W2959366 @default.
• W2959366 hasPrimaryLocation W29593661 @default.
• W2959366 hasRelatedWork W1998119898 @default.
• W2959366 hasRelatedWork W2076626517 @default.
• W2959366 hasRelatedWork W2077744056 @default.
• W2959366 hasRelatedWork W2113377893 @default.
• W2959366 hasRelatedWork W2547794367 @default.
• W2959366 hasRelatedWork W2566557708 @default.
• W2959366 hasRelatedWork W2916948412 @default.
• W2959366 hasRelatedWork W4234606113 @default.
• W2959366 hasRelatedWork W4324304758 @default.
• W2959366 hasRelatedWork W1896726944 @default.
• W2959366 isParatext "false" @default.
• W2959366 isRetracted "false" @default.
• W2959366 magId "2959366" @default.
• W2959366 workType "book-chapter" @default.