FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959402145> ?p ?o ?g. }

• W2959402145 abstract "The thesis reports studies on patients with epilepsy. The effects of two newly introduced anticonvulsant agents are discussed with regard to the seizure control, side effects, serum levels and their effect on the metabolism of other anticonvulsant drugs when used in combination. Some of the metabolic changes induced by anticonvulsant medication are reported. The introduction to the thesis gives an account of the general mode of action of anticonvulsant drugs, and indicates the continual search for the ideal anticonvulsant. The methods used in various analyses in this thesis are described. The thesis is then divided into two sections. The first deals with the comparative trial of the two newly introduced anticonvulsant agents, i.e. sodium valproate (EPILIM) and clonazepam (RIVOTRIL). The two drugs were studied in a cross-over trial in 32 chronic epileptic patients who were showing poor control; one of the trial drugs was added to the existing therapy for a period of 12 weeks, after which the patients took the second drug. Sodium valproate was the more effective drug with the least side effects. However, sodium valproate had more effect on other serum anticonvulsant drug levels: it increased the serum levels of pheno-barbitone and reduced those of phenytoin in some patients. The second section of the thesis deals with two of the changes in metabolism induced by the chronic intake of anticonvulsant drugs. Chapters 3, 4 and 5 deal with the incidence of serum IgA depletion, the effect of anticonvulsants on secretory IgA, the relation of serum IgA depletion to the HLA status, and the effect anticonvulsants have on lymphocyte protein synthesis. The results show that roughly one fourth of the patients studied had reduced serum IgA levels, and this directly related to the intake of phenytoin. The reduction in serum IgA was not found to be reflected on the active form of IgA, viz, secretory IgA; although found to be reduced, this was to a much lesser degree than that of the serum. The reduction in serum IgA in patients on phenytoin was related to the higher incidence of a specific HLA pattern in these patients. HLA-A2 was much more prevalent in these patients than in patients on the same medication but who did not have a low serum IgA level. Lymphocyte protein synthesis was found to be reduced in all patients on anticonvulsants when compared to controls. During the IgA studies serum folate was measured, and it was found to be reduced in 90% of the patients. This was further studied in Chapters 7 and 8. Serum folate was found to be reduced in most of the patients studied. Those who had the lowest serum folate levels had CSF examination for folate, which was found to be reduced as well. The effects of treating patients with low serum and CSF folate is reported. The treatment was with folic acid or with 5-formyltetrahydrofolate. The effects of treatment on seizure frequency, serum anticonvulsant levels and CSF amine metabolites (HVA and HIAA) were studied. The results show that CSF folate increased more with 5-formyltetrahydrofolate treatment. Serum phenytoin levels were reduced with treatment, and the levels of HVA and HIAA were reduced with 5-formyl-tetrahydrofolate; there was, however, no effect on seizure frequency." @default.
• W2959402145 created "2019-07-23" @default.
• W2959402145 creator A5041806804 @default.
• W2959402145 date "1977-01-01" @default.
• W2959402145 modified "2023-09-23" @default.
• W2959402145 title "Metabolic and pharmacological observations during drug treatment of epilepsy" @default.
• W2959402145 cites W1512152103 @default.
• W2959402145 cites W1974092216 @default.
• W2959402145 cites W1976502720 @default.
• W2959402145 cites W1980472324 @default.
• W2959402145 cites W1982039936 @default.
• W2959402145 cites W1984114233 @default.
• W2959402145 cites W1988255063 @default.
• W2959402145 cites W1993424506 @default.
• W2959402145 cites W1995170093 @default.
• W2959402145 cites W1995891215 @default.
• W2959402145 cites W2005459803 @default.
• W2959402145 cites W2007072103 @default.
• W2959402145 cites W2008017621 @default.
• W2959402145 cites W2015659398 @default.
• W2959402145 cites W2032080191 @default.
• W2959402145 cites W2032805174 @default.
• W2959402145 cites W2035099783 @default.
• W2959402145 cites W2035499872 @default.
• W2959402145 cites W2035819920 @default.
• W2959402145 cites W2042656260 @default.
• W2959402145 cites W2054779080 @default.
• W2959402145 cites W2055606434 @default.
• W2959402145 cites W2058053536 @default.
• W2959402145 cites W2061843699 @default.
• W2959402145 cites W2063406330 @default.
• W2959402145 cites W2070891569 @default.
• W2959402145 cites W2081733061 @default.
• W2959402145 cites W2082261415 @default.
• W2959402145 cites W2083720086 @default.
• W2959402145 cites W2106025389 @default.
• W2959402145 cites W2126876613 @default.
• W2959402145 cites W2128714051 @default.
• W2959402145 cites W2131995613 @default.
• W2959402145 cites W2134657714 @default.
• W2959402145 cites W2147683648 @default.
• W2959402145 cites W2149392077 @default.
• W2959402145 cites W2161623204 @default.
• W2959402145 cites W2261908315 @default.
• W2959402145 cites W2325314114 @default.
• W2959402145 cites W2414545419 @default.
• W2959402145 cites W2416083118 @default.
• W2959402145 cites W2467384335 @default.
• W2959402145 cites W5890223 @default.
• W2959402145 hasPublicationYear "1977" @default.
• W2959402145 type Work @default.
• W2959402145 sameAs 2959402145 @default.
• W2959402145 citedByCount "0" @default.
• W2959402145 crossrefType "dissertation" @default.
• W2959402145 hasAuthorship W2959402145A5041806804 @default.
• W2959402145 hasConcept C118552586 @default.
• W2959402145 hasConcept C2775858608 @default.
• W2959402145 hasConcept C2777172819 @default.
• W2959402145 hasConcept C2778186239 @default.
• W2959402145 hasConcept C2778337148 @default.
• W2959402145 hasConcept C2779426884 @default.
• W2959402145 hasConcept C2780035454 @default.
• W2959402145 hasConcept C2910797910 @default.
• W2959402145 hasConcept C71924100 @default.
• W2959402145 hasConcept C98274493 @default.
• W2959402145 hasConceptScore W2959402145C118552586 @default.
• W2959402145 hasConceptScore W2959402145C2775858608 @default.
• W2959402145 hasConceptScore W2959402145C2777172819 @default.
• W2959402145 hasConceptScore W2959402145C2778186239 @default.
• W2959402145 hasConceptScore W2959402145C2778337148 @default.
• W2959402145 hasConceptScore W2959402145C2779426884 @default.
• W2959402145 hasConceptScore W2959402145C2780035454 @default.
• W2959402145 hasConceptScore W2959402145C2910797910 @default.
• W2959402145 hasConceptScore W2959402145C71924100 @default.
• W2959402145 hasConceptScore W2959402145C98274493 @default.
• W2959402145 hasLocation W29594021451 @default.
• W2959402145 hasOpenAccess W2959402145 @default.
• W2959402145 hasPrimaryLocation W29594021451 @default.
• W2959402145 hasRelatedWork W117457994 @default.
• W2959402145 hasRelatedWork W1492141371 @default.
• W2959402145 hasRelatedWork W194263294 @default.
• W2959402145 hasRelatedWork W1977446983 @default.
• W2959402145 hasRelatedWork W2004395583 @default.
• W2959402145 hasRelatedWork W2015478749 @default.
• W2959402145 hasRelatedWork W2027901910 @default.
• W2959402145 hasRelatedWork W2035743726 @default.
• W2959402145 hasRelatedWork W2063406330 @default.
• W2959402145 hasRelatedWork W2064534077 @default.
• W2959402145 hasRelatedWork W2073150837 @default.
• W2959402145 hasRelatedWork W2076795343 @default.
• W2959402145 hasRelatedWork W2086974388 @default.
• W2959402145 hasRelatedWork W2359631181 @default.
• W2959402145 hasRelatedWork W2399128038 @default.
• W2959402145 hasRelatedWork W2399479269 @default.
• W2959402145 hasRelatedWork W2409077256 @default.
• W2959402145 hasRelatedWork W2423131576 @default.
• W2959402145 hasRelatedWork W2595097 @default.
• W2959402145 hasRelatedWork W95036125 @default.
• W2959402145 isParatext "false" @default.
• W2959402145 isRetracted "false" @default.

• next