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- W2959437082 endingPage "12610" @default.
- W2959437082 startingPage "12601" @default.
- W2959437082 abstract "Abstract Polymer micelles are an attractive means to solubilize water insoluble compounds such as drugs. Drug loading, formulations stability and control over drug release are crucial factors for drug‐loaded polymer micelles. The interactions between the polymeric host and the guest molecules are considered critical to control these factors but typically barely understood. Here, we compare two isomeric polymer micelles, one of which enables ultra‐high curcumin loading exceeding 50 wt.%, while the other allows a drug loading of only 25 wt.%. In the low capacity micelles, steady‐state fluorescence revealed a very unusual feature of curcumin fluorescence, a high energy emission at 510 nm. Time‐resolved fluorescence upconversion showed that the fluorescence life time of the corresponding species is too short in the high‐capacity micelles, preventing an observable emission in steady‐state. Therefore, contrary to common perception, stronger interactions between host and guest can be detrimental to the drug loading in polymer micelles." @default.
- W2959437082 created "2019-07-23" @default.
- W2959437082 creator A5025070309 @default.
- W2959437082 creator A5030662144 @default.
- W2959437082 creator A5049819232 @default.
- W2959437082 creator A5073761398 @default.
- W2959437082 creator A5078054639 @default.
- W2959437082 creator A5083856458 @default.
- W2959437082 date "2019-09-02" @default.
- W2959437082 modified "2023-10-16" @default.
- W2959437082 title "Ultra‐High to Ultra‐Low Drug‐Loaded Micelles: Probing Host–Guest Interactions by Fluorescence Spectroscopy" @default.
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- W2959437082 doi "https://doi.org/10.1002/chem.201902619" @default.
- W2959437082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6790594" @default.
- W2959437082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31291028" @default.
- W2959437082 hasPublicationYear "2019" @default.