FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W295947620> ?p ?o ?g. }

• W295947620 endingPage "1094" @default.
• W295947620 startingPage "1086" @default.
• W295947620 abstract "Ganoderma applanatum (GA) and related fungal species have been used for over 2000 years in China to prevent and treat various human diseases. However, there is no critical research evaluating the functionality of GA grown using submerged culture technology. This study aimed to evaluate the effects of submerged culture GA mycelium (GAM) and its active components (protocatechualdehyde [PCA]) on preadipocyte differentiation of 3T3-L1 cells. Mouse-derived preadipocyte 3T3-L1 cells were treated with differentiation inducers in the presence or absence of GAM extracts. We determined triglyceride accumulations, glycerol-3-phosphate dehydrogenase (GPDH) activities, and differentiation makers. PCA, the active component of GAM extract, was also used to treat 3T3-L1 cells. The MTT assay showed that the GAM extract (0.01–1 mg/mL) was not toxic to 3T3-L1 preadipocyte. Treatment of cells with GAM extracts and its active components significantly decreased the GPDH activity and lipid accumulation, a marker of adipogenesis, in a dose-dependent manner. Western blot analysis results showed that the protein expression levels of peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), and sterol regulatory element-binding protein 1 (SREBP1) were inhibited by the GAM extract. In addition, adipogenic-specific genes such as perilipin, fatty acid synthase (FAS), fatty acid transport protein 1 (FATP1), and fatty acid-binding protein 4 (FABP4) decreased in a dose-dependent manner. Quantitative high-performance liquid chromatography analysis showed that the GAM extract contained 1.14 mg/g PCA. GAM extracts suppressed differentiation of 3T3-L1 preadipocytes, in part, through altered regulation of PPARγ, C/EBPα, and SREBP1. These results suggest that GAM extracts and PCA may suppress adipogenesis by inhibiting differentiation of preadipocytes." @default.
• W295947620 created "2016-06-24" @default.
• W295947620 creator A5003798955 @default.
• W295947620 creator A5056751351 @default.
• W295947620 creator A5058973542 @default.
• W295947620 creator A5091644368 @default.
• W295947620 date "2014-10-01" @default.
• W295947620 modified "2023-10-16" @default.
• W295947620 title "Effect of<i>Ganoderma applanatum</i>Mycelium Extract on the Inhibition of Adipogenesis in 3T3-L1 Adipocytes" @default.
• W295947620 cites W1815087127 @default.
• W295947620 cites W1927710737 @default.
• W295947620 cites W1973860866 @default.
• W295947620 cites W1978615651 @default.
• W295947620 cites W1979444675 @default.
• W295947620 cites W1980508602 @default.
• W295947620 cites W1983876811 @default.
• W295947620 cites W1988944841 @default.
• W295947620 cites W1992637577 @default.
• W295947620 cites W1998464620 @default.
• W295947620 cites W2002519246 @default.
• W295947620 cites W2002535786 @default.
• W295947620 cites W2029041659 @default.
• W295947620 cites W2034810986 @default.
• W295947620 cites W2036812212 @default.
• W295947620 cites W2038537815 @default.
• W295947620 cites W2042764090 @default.
• W295947620 cites W2043608843 @default.
• W295947620 cites W2052292499 @default.
• W295947620 cites W2053018847 @default.
• W295947620 cites W2057162495 @default.
• W295947620 cites W2067468162 @default.
• W295947620 cites W2069193571 @default.
• W295947620 cites W2093596347 @default.
• W295947620 cites W2094115400 @default.
• W295947620 cites W2098124393 @default.
• W295947620 cites W2101691812 @default.
• W295947620 cites W2102313291 @default.
• W295947620 cites W2109533391 @default.
• W295947620 cites W2137871454 @default.
• W295947620 cites W2143789137 @default.
• W295947620 cites W2153002689 @default.
• W295947620 cites W2161292238 @default.
• W295947620 cites W2169273666 @default.
• W295947620 doi "https://doi.org/10.1089/jmf.2013.3036" @default.
• W295947620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25140758" @default.
• W295947620 hasPublicationYear "2014" @default.
• W295947620 type Work @default.
• W295947620 sameAs 295947620 @default.
• W295947620 citedByCount "8" @default.
• W295947620 countsByYear W2959476202015 @default.
• W295947620 countsByYear W2959476202016 @default.
• W295947620 countsByYear W2959476202018 @default.
• W295947620 countsByYear W2959476202020 @default.
• W295947620 crossrefType "journal-article" @default.
• W295947620 hasAuthorship W295947620A5003798955 @default.
• W295947620 hasAuthorship W295947620A5056751351 @default.
• W295947620 hasAuthorship W295947620A5058973542 @default.
• W295947620 hasAuthorship W295947620A5091644368 @default.
• W295947620 hasConcept C104317684 @default.
• W295947620 hasConcept C122927707 @default.
• W295947620 hasConcept C127078168 @default.
• W295947620 hasConcept C140985366 @default.
• W295947620 hasConcept C142536801 @default.
• W295947620 hasConcept C153911025 @default.
• W295947620 hasConcept C170493617 @default.
• W295947620 hasConcept C171089720 @default.
• W295947620 hasConcept C185592680 @default.
• W295947620 hasConcept C25095133 @default.
• W295947620 hasConcept C2776834966 @default.
• W295947620 hasConcept C2778163477 @default.
• W295947620 hasConcept C2778718757 @default.
• W295947620 hasConcept C39567582 @default.
• W295947620 hasConcept C48289651 @default.
• W295947620 hasConcept C543025807 @default.
• W295947620 hasConcept C55493867 @default.
• W295947620 hasConcept C85051948 @default.
• W295947620 hasConcept C86803240 @default.
• W295947620 hasConceptScore W295947620C104317684 @default.
• W295947620 hasConceptScore W295947620C122927707 @default.
• W295947620 hasConceptScore W295947620C127078168 @default.
• W295947620 hasConceptScore W295947620C140985366 @default.
• W295947620 hasConceptScore W295947620C142536801 @default.
• W295947620 hasConceptScore W295947620C153911025 @default.
• W295947620 hasConceptScore W295947620C170493617 @default.
• W295947620 hasConceptScore W295947620C171089720 @default.
• W295947620 hasConceptScore W295947620C185592680 @default.
• W295947620 hasConceptScore W295947620C25095133 @default.
• W295947620 hasConceptScore W295947620C2776834966 @default.
• W295947620 hasConceptScore W295947620C2778163477 @default.
• W295947620 hasConceptScore W295947620C2778718757 @default.
• W295947620 hasConceptScore W295947620C39567582 @default.
• W295947620 hasConceptScore W295947620C48289651 @default.
• W295947620 hasConceptScore W295947620C543025807 @default.
• W295947620 hasConceptScore W295947620C55493867 @default.
• W295947620 hasConceptScore W295947620C85051948 @default.
• W295947620 hasConceptScore W295947620C86803240 @default.
• W295947620 hasIssue "10" @default.
• W295947620 hasLocation W2959476201 @default.

• next