FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959483276> ?p ?o ?g. }

• W2959483276 endingPage "213" @default.
• W2959483276 startingPage "199" @default.
• W2959483276 abstract "Adaptive designs play an important role in contemporary clinical trials to make designs flexible and efficient. In cancer clinical trials, given a relatively small sample size, it is important to obtain as much information as possible during this phase. We propose a new adaptive optimal design that stops for futility only in the first stage as Simon’s two-stage design. The existing adaptive two-stage designs are often allowed to be stopped for futility or efficacy due to computational advantage. It is difficult to search for an optimal design with futility stopping only in the first stage by using efficient search algorithms; for example, the branch-and-bound algorithm. We have to use multiple computational techniques to search for the optimal design. The proposed adaptive design meets the important property of the monotonic property that the second stage sample size is a nonincreasing function of the number of responses from the first stage. In this article, we show that the proposed adaptive design always has a smaller expected sample size than Simon’s optimal design. We recommend it for use in practice as an alternative to the commonly used Simon’s design." @default.
• W2959483276 created "2019-07-23" @default.
• W2959483276 creator A5049148779 @default.
• W2959483276 creator A5056450584 @default.
• W2959483276 creator A5078277073 @default.
• W2959483276 date "2019-04-03" @default.
• W2959483276 modified "2023-09-27" @default.
• W2959483276 title "Adaptive two-stage optimal designs for phase II clinical studies that allow early futility stopping" @default.
• W2959483276 cites W1911130923 @default.
• W2959483276 cites W1914095056 @default.
• W2959483276 cites W1988952766 @default.
• W2959483276 cites W1993122793 @default.
• W2959483276 cites W1998950854 @default.
• W2959483276 cites W2001203833 @default.
• W2959483276 cites W2003501460 @default.
• W2959483276 cites W2016306015 @default.
• W2959483276 cites W2029409133 @default.
• W2959483276 cites W2044439361 @default.
• W2959483276 cites W2056445663 @default.
• W2959483276 cites W2072849349 @default.
• W2959483276 cites W2092241508 @default.
• W2959483276 cites W2119131749 @default.
• W2959483276 cites W2122847822 @default.
• W2959483276 cites W2136666944 @default.
• W2959483276 cites W2139248078 @default.
• W2959483276 cites W2464091985 @default.
• W2959483276 cites W2799535307 @default.
• W2959483276 doi "https://doi.org/10.1080/07474946.2019.1611307" @default.
• W2959483276 hasPublicationYear "2019" @default.
• W2959483276 type Work @default.
• W2959483276 sameAs 2959483276 @default.
• W2959483276 citedByCount "12" @default.
• W2959483276 countsByYear W29594832762020 @default.
• W2959483276 countsByYear W29594832762021 @default.
• W2959483276 countsByYear W29594832762022 @default.
• W2959483276 countsByYear W29594832762023 @default.
• W2959483276 crossrefType "journal-article" @default.
• W2959483276 hasAuthorship W2959483276A5049148779 @default.
• W2959483276 hasAuthorship W2959483276A5056450584 @default.
• W2959483276 hasAuthorship W2959483276A5078277073 @default.
• W2959483276 hasConcept C105795698 @default.
• W2959483276 hasConcept C111472728 @default.
• W2959483276 hasConcept C126255220 @default.
• W2959483276 hasConcept C129848803 @default.
• W2959483276 hasConcept C134306372 @default.
• W2959483276 hasConcept C138885662 @default.
• W2959483276 hasConcept C14036430 @default.
• W2959483276 hasConcept C142724271 @default.
• W2959483276 hasConcept C146357865 @default.
• W2959483276 hasConcept C151730666 @default.
• W2959483276 hasConcept C154945302 @default.
• W2959483276 hasConcept C186394612 @default.
• W2959483276 hasConcept C189950617 @default.
• W2959483276 hasConcept C2982777018 @default.
• W2959483276 hasConcept C33923547 @default.
• W2959483276 hasConcept C41008148 @default.
• W2959483276 hasConcept C50644808 @default.
• W2959483276 hasConcept C535046627 @default.
• W2959483276 hasConcept C5465570 @default.
• W2959483276 hasConcept C71924100 @default.
• W2959483276 hasConcept C72169020 @default.
• W2959483276 hasConcept C78458016 @default.
• W2959483276 hasConcept C86803240 @default.
• W2959483276 hasConcept C99414536 @default.
• W2959483276 hasConceptScore W2959483276C105795698 @default.
• W2959483276 hasConceptScore W2959483276C111472728 @default.
• W2959483276 hasConceptScore W2959483276C126255220 @default.
• W2959483276 hasConceptScore W2959483276C129848803 @default.
• W2959483276 hasConceptScore W2959483276C134306372 @default.
• W2959483276 hasConceptScore W2959483276C138885662 @default.
• W2959483276 hasConceptScore W2959483276C14036430 @default.
• W2959483276 hasConceptScore W2959483276C142724271 @default.
• W2959483276 hasConceptScore W2959483276C146357865 @default.
• W2959483276 hasConceptScore W2959483276C151730666 @default.
• W2959483276 hasConceptScore W2959483276C154945302 @default.
• W2959483276 hasConceptScore W2959483276C186394612 @default.
• W2959483276 hasConceptScore W2959483276C189950617 @default.
• W2959483276 hasConceptScore W2959483276C2982777018 @default.
• W2959483276 hasConceptScore W2959483276C33923547 @default.
• W2959483276 hasConceptScore W2959483276C41008148 @default.
• W2959483276 hasConceptScore W2959483276C50644808 @default.
• W2959483276 hasConceptScore W2959483276C535046627 @default.
• W2959483276 hasConceptScore W2959483276C5465570 @default.
• W2959483276 hasConceptScore W2959483276C71924100 @default.
• W2959483276 hasConceptScore W2959483276C72169020 @default.
• W2959483276 hasConceptScore W2959483276C78458016 @default.
• W2959483276 hasConceptScore W2959483276C86803240 @default.
• W2959483276 hasConceptScore W2959483276C99414536 @default.
• W2959483276 hasIssue "2" @default.
• W2959483276 hasLocation W29594832761 @default.
• W2959483276 hasOpenAccess W2959483276 @default.
• W2959483276 hasPrimaryLocation W29594832761 @default.
• W2959483276 hasRelatedWork W1605150308 @default.
• W2959483276 hasRelatedWork W1689693563 @default.
• W2959483276 hasRelatedWork W2074357263 @default.
• W2959483276 hasRelatedWork W2074593928 @default.
• W2959483276 hasRelatedWork W2141724682 @default.
• W2959483276 hasRelatedWork W2888817772 @default.

• next