FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959506502> ?p ?o ?g. }

• W2959506502 endingPage "316" @default.
• W2959506502 startingPage "308" @default.
• W2959506502 abstract "Methotrexate (MTX), which has been used in clinical practice for approximately 70 years, is still widely employed in the treatment of rheumatoid arthritis (RA), psoriasis, and cancer. Although MTX toxicity causes nephrotoxicity, hepatotoxicity, bone marrow suppression, pulmonary fibrosis, and gastrointestinal damage, previous studies have not addressed splenic toxicity. This is the first study to examine the effectiveness of infliximab (INF) against MTX-induced toxicity in splenic tissues via the regulation of CD3, CD68, and C200R. We investigated the effects of MTX on macrophages and T lymphocytes in the spleen at the molecular level and examined the protective potential of the tumor necrosis factor (TNF)-α antagonist INF against MTX toxicity. Three groups of rats were set up. Group 1 received saline solution only, group 2 a single dose of MTX (20 mg/kg), and group 3 INF (7 mg/kg) before administration of a single dose of MTX (20 mg/kg). All injections were given intraperitoneally. Spleen tissues were removed 5 days after MTX administration and evaluated for CD3, CD68, and CD200R using immunohistochemical staining. Finally, the mean numerical density of CD3+, CD68+, and CD200R+ cells was estimated by a histopathologist using StereoInvestigator 8. MTX increased the numerical densities of CD3+, CD68+, and CD200R+ cells (<i>p</i> &#x3c; 0.05). We also observed that INF reduced the numerical densities of these cells following MTX administration (<i>p</i> &#x3c; 0.05). INF may, therefore, be a promising candidate for the prevention of the deleterious effects on spleen tissue of MTX, used in the treatment of RA and cancer." @default.
• W2959506502 created "2019-07-23" @default.
• W2959506502 creator A5007711124 @default.
• W2959506502 creator A5033019362 @default.
• W2959506502 creator A5086383005 @default.
• W2959506502 date "2018-01-01" @default.
• W2959506502 modified "2023-10-18" @default.
• W2959506502 title "Effects of Infliximab against Methotrexate Toxicity in Splenic Tissue via the Regulation of CD3, CD68, and C200R in Rats" @default.
• W2959506502 cites W1521663232 @default.
• W2959506502 cites W1571985114 @default.
• W2959506502 cites W1965805595 @default.
• W2959506502 cites W1972188754 @default.
• W2959506502 cites W1984325684 @default.
• W2959506502 cites W1993748281 @default.
• W2959506502 cites W1994698148 @default.
• W2959506502 cites W1996472975 @default.
• W2959506502 cites W1996845889 @default.
• W2959506502 cites W2001220220 @default.
• W2959506502 cites W2003063234 @default.
• W2959506502 cites W2003777556 @default.
• W2959506502 cites W2010395737 @default.
• W2959506502 cites W2021659381 @default.
• W2959506502 cites W2022188355 @default.
• W2959506502 cites W2027749968 @default.
• W2959506502 cites W2032218738 @default.
• W2959506502 cites W2038316668 @default.
• W2959506502 cites W2046480189 @default.
• W2959506502 cites W2049294027 @default.
• W2959506502 cites W2055402349 @default.
• W2959506502 cites W2059012866 @default.
• W2959506502 cites W2063827687 @default.
• W2959506502 cites W2066418743 @default.
• W2959506502 cites W2102370802 @default.
• W2959506502 cites W2111884823 @default.
• W2959506502 cites W2119078016 @default.
• W2959506502 cites W2133794582 @default.
• W2959506502 cites W2164815203 @default.
• W2959506502 cites W2165571611 @default.
• W2959506502 cites W2170349508 @default.
• W2959506502 cites W2171983185 @default.
• W2959506502 cites W2316011652 @default.
• W2959506502 cites W2345450983 @default.
• W2959506502 cites W2345908765 @default.
• W2959506502 cites W2346007408 @default.
• W2959506502 cites W2369174845 @default.
• W2959506502 cites W2545158951 @default.
• W2959506502 cites W2560348215 @default.
• W2959506502 cites W2608782123 @default.
• W2959506502 cites W2745126636 @default.
• W2959506502 cites W2767752678 @default.
• W2959506502 cites W2773624951 @default.
• W2959506502 cites W2786954262 @default.
• W2959506502 cites W2793582460 @default.
• W2959506502 cites W2891474673 @default.
• W2959506502 cites W2908554976 @default.
• W2959506502 doi "https://doi.org/10.1159/000500905" @default.
• W2959506502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31284287" @default.
• W2959506502 hasPublicationYear "2018" @default.
• W2959506502 type Work @default.
• W2959506502 sameAs 2959506502 @default.
• W2959506502 citedByCount "4" @default.
• W2959506502 countsByYear W29595065022021 @default.
• W2959506502 countsByYear W29595065022022 @default.
• W2959506502 countsByYear W29595065022023 @default.
• W2959506502 crossrefType "journal-article" @default.
• W2959506502 hasAuthorship W2959506502A5007711124 @default.
• W2959506502 hasAuthorship W2959506502A5033019362 @default.
• W2959506502 hasAuthorship W2959506502A5086383005 @default.
• W2959506502 hasConcept C126189478 @default.
• W2959506502 hasConcept C126322002 @default.
• W2959506502 hasConcept C142724271 @default.
• W2959506502 hasConcept C17991360 @default.
• W2959506502 hasConcept C203014093 @default.
• W2959506502 hasConcept C204232928 @default.
• W2959506502 hasConcept C2776460901 @default.
• W2959506502 hasConcept C2777575956 @default.
• W2959506502 hasConcept C2780931953 @default.
• W2959506502 hasConcept C2781059491 @default.
• W2959506502 hasConcept C29730261 @default.
• W2959506502 hasConcept C71924100 @default.
• W2959506502 hasConcept C98274493 @default.
• W2959506502 hasConceptScore W2959506502C126189478 @default.
• W2959506502 hasConceptScore W2959506502C126322002 @default.
• W2959506502 hasConceptScore W2959506502C142724271 @default.
• W2959506502 hasConceptScore W2959506502C17991360 @default.
• W2959506502 hasConceptScore W2959506502C203014093 @default.
• W2959506502 hasConceptScore W2959506502C204232928 @default.
• W2959506502 hasConceptScore W2959506502C2776460901 @default.
• W2959506502 hasConceptScore W2959506502C2777575956 @default.
• W2959506502 hasConceptScore W2959506502C2780931953 @default.
• W2959506502 hasConceptScore W2959506502C2781059491 @default.
• W2959506502 hasConceptScore W2959506502C29730261 @default.
• W2959506502 hasConceptScore W2959506502C71924100 @default.
• W2959506502 hasConceptScore W2959506502C98274493 @default.
• W2959506502 hasIssue "6" @default.
• W2959506502 hasLocation W29595065021 @default.
• W2959506502 hasLocation W29595065022 @default.
• W2959506502 hasOpenAccess W2959506502 @default.

• next