Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959533867> ?p ?o ?g. }
- W2959533867 abstract "The erasure of epigenetic modifications across the genome of somatic cells is an essential requirement during their reprogramming into induced pluripotent stem cells (iPSCs). Vitamin C plays a pivotal role in remodeling the epigenome by enhancing the activity of Jumonji-C domain-containing histone demethylases (JHDMs) and the Ten-eleven translocation proteins (TETs). By maintaining differentiation plasticity in culture, vitamin C also improves the quality of tissue specific stem cells derived from iPSCs that are highly sought after for use in regenerative medicine. The ability of vitamin C to potentiate the activity of histone and DNA demethylating enzymes also has clinical application in the treatment of cancer. Vitamin C deficiency has been widely reported in cancer patients and has recently been shown to accelerate cancer progression in disease models. Therapies involving high-dose vitamin C administration are currently gaining traction in the treatment of epigenetic dysregulation, by targeting aberrant histone and DNA methylation patterns associated with cancer progression." @default.
- W2959533867 created "2019-07-23" @default.
- W2959533867 creator A5020072250 @default.
- W2959533867 creator A5033383318 @default.
- W2959533867 creator A5075853107 @default.
- W2959533867 date "2019-07-16" @default.
- W2959533867 modified "2023-10-17" @default.
- W2959533867 title "Reprogramming the Epigenome With Vitamin C" @default.
- W2959533867 cites W1171241794 @default.
- W2959533867 cites W1505439893 @default.
- W2959533867 cites W1874303456 @default.
- W2959533867 cites W1934491273 @default.
- W2959533867 cites W1960166151 @default.
- W2959533867 cites W1964487182 @default.
- W2959533867 cites W1967415928 @default.
- W2959533867 cites W1971208758 @default.
- W2959533867 cites W1972298775 @default.
- W2959533867 cites W1973541913 @default.
- W2959533867 cites W1975984062 @default.
- W2959533867 cites W1977554464 @default.
- W2959533867 cites W1978262131 @default.
- W2959533867 cites W1978407431 @default.
- W2959533867 cites W1981463058 @default.
- W2959533867 cites W1982409009 @default.
- W2959533867 cites W1986118996 @default.
- W2959533867 cites W1988027547 @default.
- W2959533867 cites W1988756388 @default.
- W2959533867 cites W1989134151 @default.
- W2959533867 cites W1991698857 @default.
- W2959533867 cites W1993627126 @default.
- W2959533867 cites W1995675594 @default.
- W2959533867 cites W1999391198 @default.
- W2959533867 cites W2001284661 @default.
- W2959533867 cites W2007922873 @default.
- W2959533867 cites W2008420899 @default.
- W2959533867 cites W2010370140 @default.
- W2959533867 cites W2012588998 @default.
- W2959533867 cites W2014623973 @default.
- W2959533867 cites W2016534953 @default.
- W2959533867 cites W2016923091 @default.
- W2959533867 cites W2018113993 @default.
- W2959533867 cites W2019019085 @default.
- W2959533867 cites W2020016210 @default.
- W2959533867 cites W2020423861 @default.
- W2959533867 cites W2023172513 @default.
- W2959533867 cites W2023765801 @default.
- W2959533867 cites W2026900358 @default.
- W2959533867 cites W2028817794 @default.
- W2959533867 cites W2029813631 @default.
- W2959533867 cites W2030372181 @default.
- W2959533867 cites W2035905956 @default.
- W2959533867 cites W2037149683 @default.
- W2959533867 cites W2043457504 @default.
- W2959533867 cites W2046743171 @default.
- W2959533867 cites W2048786084 @default.
- W2959533867 cites W2051293191 @default.
- W2959533867 cites W2054157163 @default.
- W2959533867 cites W2054643318 @default.
- W2959533867 cites W2063430478 @default.
- W2959533867 cites W2063891109 @default.
- W2959533867 cites W2065549871 @default.
- W2959533867 cites W2066064778 @default.
- W2959533867 cites W2066414785 @default.
- W2959533867 cites W2066442023 @default.
- W2959533867 cites W2068050716 @default.
- W2959533867 cites W2069428487 @default.
- W2959533867 cites W2069932077 @default.
- W2959533867 cites W2070334796 @default.
- W2959533867 cites W2070789023 @default.
- W2959533867 cites W2071445941 @default.
- W2959533867 cites W2071930821 @default.
- W2959533867 cites W2073429636 @default.
- W2959533867 cites W2073872690 @default.
- W2959533867 cites W2075052989 @default.
- W2959533867 cites W2075472427 @default.
- W2959533867 cites W2075748969 @default.
- W2959533867 cites W2076047032 @default.
- W2959533867 cites W2077538054 @default.
- W2959533867 cites W2078972833 @default.
- W2959533867 cites W2079840468 @default.
- W2959533867 cites W2080201494 @default.
- W2959533867 cites W2080452140 @default.
- W2959533867 cites W2084037323 @default.
- W2959533867 cites W2086074238 @default.
- W2959533867 cites W2092138220 @default.
- W2959533867 cites W2092780119 @default.
- W2959533867 cites W2097036103 @default.
- W2959533867 cites W2097743943 @default.
- W2959533867 cites W2100465572 @default.
- W2959533867 cites W2102560467 @default.
- W2959533867 cites W2103612759 @default.
- W2959533867 cites W2104852749 @default.
- W2959533867 cites W2107279676 @default.
- W2959533867 cites W2107751591 @default.
- W2959533867 cites W2108664872 @default.
- W2959533867 cites W2108764934 @default.
- W2959533867 cites W2111694985 @default.
- W2959533867 cites W2111737305 @default.
- W2959533867 cites W2111920812 @default.
- W2959533867 cites W2118121677 @default.