Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959539918> ?p ?o ?g. }
- W2959539918 endingPage "1652" @default.
- W2959539918 startingPage "1644" @default.
- W2959539918 abstract "Abstract Background Major depressive disorder (MDD) represents a leading cause of disability. This study examines the course of disability in patients with chronic, recurrent and remitting MDD compared to healthy controls and identifies predictors of disability in remitting MDD. Methods We included 914 participants from the Netherlands Study of Depression and Anxiety (NESDA). DSM-IV MDD and WHO DAS II disability were assessed at baseline and at 2, 4 and 6 years. Six-year total and domain-specific disability were analysed and compared in participants with chronic ( n = 57), recurrent ( n = 120), remitting ( n = 127) MDD and in healthy controls ( n = 430). Predictors of residual disability were identified using linear regression analysis. Results At baseline, most disability was found in chronic MDD, followed by recurrent MDD, remitting MDD and healthy controls. Across diagnostic groups, most disability was found in household activities, interpersonal functioning, participation in society and cognition. A chronic course was associated with chronic disability. Symptom remission was associated with a decrease in disability, but some disability remained. In remitting MDD, higher residual disability was predicted by older age, more severe avoidance symptoms, higher disability at baseline and late symptom remission. Severity of residual disability correlated with the severity of residual depressive symptoms. Conclusions Symptomatic remission is a prerequisite for improvements in disability. However, disability persists despite symptom remission. Therefore, treatment of MDD should include an explicit focus on disability, especially on the more complex domains. To this end, treatments should promote behavioural activation and address subthreshold depressive symptoms in patients with remitted MDD." @default.
- W2959539918 created "2019-07-23" @default.
- W2959539918 creator A5010741856 @default.
- W2959539918 creator A5044751878 @default.
- W2959539918 creator A5045274254 @default.
- W2959539918 creator A5049037054 @default.
- W2959539918 creator A5071247199 @default.
- W2959539918 date "2019-07-09" @default.
- W2959539918 modified "2023-10-17" @default.
- W2959539918 title "Long-term disability in major depressive disorder: a 6-year follow-up study" @default.
- W2959539918 cites W1502506271 @default.
- W2959539918 cites W1971568036 @default.
- W2959539918 cites W1989058805 @default.
- W2959539918 cites W1992670387 @default.
- W2959539918 cites W2000014323 @default.
- W2959539918 cites W2016882330 @default.
- W2959539918 cites W2023141616 @default.
- W2959539918 cites W2023681059 @default.
- W2959539918 cites W2037061841 @default.
- W2959539918 cites W2037304868 @default.
- W2959539918 cites W2045557513 @default.
- W2959539918 cites W2051741287 @default.
- W2959539918 cites W2055526664 @default.
- W2959539918 cites W2058879410 @default.
- W2959539918 cites W2064659434 @default.
- W2959539918 cites W2099564119 @default.
- W2959539918 cites W2107213230 @default.
- W2959539918 cites W2110608362 @default.
- W2959539918 cites W2119331211 @default.
- W2959539918 cites W2122855245 @default.
- W2959539918 cites W2124084192 @default.
- W2959539918 cites W2127124395 @default.
- W2959539918 cites W2127857741 @default.
- W2959539918 cites W2129088015 @default.
- W2959539918 cites W2131773019 @default.
- W2959539918 cites W2138202604 @default.
- W2959539918 cites W2143461891 @default.
- W2959539918 cites W2146858477 @default.
- W2959539918 cites W2150257183 @default.
- W2959539918 cites W2153503260 @default.
- W2959539918 cites W2164705993 @default.
- W2959539918 cites W2168185946 @default.
- W2959539918 cites W2170691050 @default.
- W2959539918 cites W2171340584 @default.
- W2959539918 cites W2505590685 @default.
- W2959539918 cites W2511287903 @default.
- W2959539918 cites W2614986146 @default.
- W2959539918 cites W2782993555 @default.
- W2959539918 cites W4238079920 @default.
- W2959539918 cites W96736588 @default.
- W2959539918 doi "https://doi.org/10.1017/s0033291719001612" @default.
- W2959539918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31284881" @default.
- W2959539918 hasPublicationYear "2019" @default.
- W2959539918 type Work @default.
- W2959539918 sameAs 2959539918 @default.
- W2959539918 citedByCount "22" @default.
- W2959539918 countsByYear W29595399182020 @default.
- W2959539918 countsByYear W29595399182021 @default.
- W2959539918 countsByYear W29595399182022 @default.
- W2959539918 countsByYear W29595399182023 @default.
- W2959539918 crossrefType "journal-article" @default.
- W2959539918 hasAuthorship W2959539918A5010741856 @default.
- W2959539918 hasAuthorship W2959539918A5044751878 @default.
- W2959539918 hasAuthorship W2959539918A5045274254 @default.
- W2959539918 hasAuthorship W2959539918A5049037054 @default.
- W2959539918 hasAuthorship W2959539918A5071247199 @default.
- W2959539918 hasConcept C118552586 @default.
- W2959539918 hasConcept C139719470 @default.
- W2959539918 hasConcept C15744967 @default.
- W2959539918 hasConcept C162324750 @default.
- W2959539918 hasConcept C169900460 @default.
- W2959539918 hasConcept C2776867660 @default.
- W2959539918 hasConcept C2780051608 @default.
- W2959539918 hasConcept C558461103 @default.
- W2959539918 hasConcept C70410870 @default.
- W2959539918 hasConcept C71924100 @default.
- W2959539918 hasConceptScore W2959539918C118552586 @default.
- W2959539918 hasConceptScore W2959539918C139719470 @default.
- W2959539918 hasConceptScore W2959539918C15744967 @default.
- W2959539918 hasConceptScore W2959539918C162324750 @default.
- W2959539918 hasConceptScore W2959539918C169900460 @default.
- W2959539918 hasConceptScore W2959539918C2776867660 @default.
- W2959539918 hasConceptScore W2959539918C2780051608 @default.
- W2959539918 hasConceptScore W2959539918C558461103 @default.
- W2959539918 hasConceptScore W2959539918C70410870 @default.
- W2959539918 hasConceptScore W2959539918C71924100 @default.
- W2959539918 hasIssue "10" @default.
- W2959539918 hasLocation W29595399181 @default.
- W2959539918 hasOpenAccess W2959539918 @default.
- W2959539918 hasPrimaryLocation W29595399181 @default.
- W2959539918 hasRelatedWork W2013721540 @default.
- W2959539918 hasRelatedWork W2165343866 @default.
- W2959539918 hasRelatedWork W2367402799 @default.
- W2959539918 hasRelatedWork W2377334017 @default.
- W2959539918 hasRelatedWork W2592342712 @default.
- W2959539918 hasRelatedWork W2748952813 @default.
- W2959539918 hasRelatedWork W2769243276 @default.
- W2959539918 hasRelatedWork W2899084033 @default.