Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959545135> ?p ?o ?g. }
- W2959545135 endingPage "16" @default.
- W2959545135 startingPage "1" @default.
- W2959545135 abstract "Developing scaffold materials with excellent biocompatibility, mechanical properties, and controlled drug release properties is vital to tissue engineering. In this study, we fabricated silk fibroin (SF)/poly(lactide-co-glycolide) (PLGA) nanofiber scaffolds containing recombinant human bone morphogenetic protein 2 (rhBMP2) and dexamethasone (DXM) via coaxial electrospinning, which were used in in vitro bone formation with rat bone marrow mesenchymal stem cells (rBMSCs). An in vitro drug release study was adopted to evaluate the sustained release potential of the core-shell structured nanofibers. Furthermore, we detected the potential of the SF/PLGA nanofiber membrane in vitro. In vitro studies showed that rhBMP2 still remained active on the nanofiber membrane. In addition, the dual-drug-loaded nanofiber membrane showed an early burst release of DXM and late sustained release of rhBMP2. rhBMP2 and DXM exhibited strong osteogenic differentiation potential when they acted on rBMSCs. Therefore, the SF/PLGA nanofiber membrane loaded with rhBMP2 and DXM has great potential for the enhancement of bone regeneration." @default.
- W2959545135 created "2019-07-23" @default.
- W2959545135 creator A5040824234 @default.
- W2959545135 creator A5065211450 @default.
- W2959545135 creator A5072556989 @default.
- W2959545135 creator A5075844545 @default.
- W2959545135 creator A5077771596 @default.
- W2959545135 creator A5087264282 @default.
- W2959545135 date "2019-07-16" @default.
- W2959545135 modified "2023-10-15" @default.
- W2959545135 title "Dual-Drug-Loaded Silk Fibroin/PLGA Scaffolds for Potential Bone Regeneration Applications" @default.
- W2959545135 cites W1973949906 @default.
- W2959545135 cites W1976216872 @default.
- W2959545135 cites W1994905373 @default.
- W2959545135 cites W1998727589 @default.
- W2959545135 cites W2005493243 @default.
- W2959545135 cites W2007252881 @default.
- W2959545135 cites W2007487866 @default.
- W2959545135 cites W2018948947 @default.
- W2959545135 cites W2019173905 @default.
- W2959545135 cites W2029510959 @default.
- W2959545135 cites W2032781936 @default.
- W2959545135 cites W2041842103 @default.
- W2959545135 cites W2047452815 @default.
- W2959545135 cites W2054988877 @default.
- W2959545135 cites W2068643521 @default.
- W2959545135 cites W2072739496 @default.
- W2959545135 cites W2085611905 @default.
- W2959545135 cites W2093654042 @default.
- W2959545135 cites W2093839112 @default.
- W2959545135 cites W2101114763 @default.
- W2959545135 cites W2120279340 @default.
- W2959545135 cites W2131837055 @default.
- W2959545135 cites W2138442961 @default.
- W2959545135 cites W2145215476 @default.
- W2959545135 cites W2175599349 @default.
- W2959545135 cites W2191751320 @default.
- W2959545135 cites W2280022771 @default.
- W2959545135 cites W2280635386 @default.
- W2959545135 cites W2329727066 @default.
- W2959545135 cites W2416123413 @default.
- W2959545135 cites W2508290240 @default.
- W2959545135 cites W2579920203 @default.
- W2959545135 cites W2606332132 @default.
- W2959545135 cites W2740672044 @default.
- W2959545135 cites W2767435144 @default.
- W2959545135 cites W2792511918 @default.
- W2959545135 cites W2792612030 @default.
- W2959545135 cites W2800851648 @default.
- W2959545135 cites W2886022545 @default.
- W2959545135 cites W2888170940 @default.
- W2959545135 doi "https://doi.org/10.1155/2019/8050413" @default.
- W2959545135 hasPublicationYear "2019" @default.
- W2959545135 type Work @default.
- W2959545135 sameAs 2959545135 @default.
- W2959545135 citedByCount "15" @default.
- W2959545135 countsByYear W29595451352020 @default.
- W2959545135 countsByYear W29595451352021 @default.
- W2959545135 countsByYear W29595451352022 @default.
- W2959545135 countsByYear W29595451352023 @default.
- W2959545135 crossrefType "journal-article" @default.
- W2959545135 hasAuthorship W2959545135A5040824234 @default.
- W2959545135 hasAuthorship W2959545135A5065211450 @default.
- W2959545135 hasAuthorship W2959545135A5072556989 @default.
- W2959545135 hasAuthorship W2959545135A5075844545 @default.
- W2959545135 hasAuthorship W2959545135A5077771596 @default.
- W2959545135 hasAuthorship W2959545135A5087264282 @default.
- W2959545135 hasBestOaLocation W29595451351 @default.
- W2959545135 hasConcept C122302759 @default.
- W2959545135 hasConcept C12554922 @default.
- W2959545135 hasConcept C136229726 @default.
- W2959545135 hasConcept C144796933 @default.
- W2959545135 hasConcept C155672457 @default.
- W2959545135 hasConcept C159985019 @default.
- W2959545135 hasConcept C171056886 @default.
- W2959545135 hasConcept C171250308 @default.
- W2959545135 hasConcept C185592680 @default.
- W2959545135 hasConcept C191897082 @default.
- W2959545135 hasConcept C192562407 @default.
- W2959545135 hasConcept C202751555 @default.
- W2959545135 hasConcept C2777230088 @default.
- W2959545135 hasConcept C2779820397 @default.
- W2959545135 hasConcept C2780165375 @default.
- W2959545135 hasConcept C2780431358 @default.
- W2959545135 hasConcept C30352789 @default.
- W2959545135 hasConcept C41625074 @default.
- W2959545135 hasConcept C49892992 @default.
- W2959545135 hasConcept C521977710 @default.
- W2959545135 hasConcept C55493867 @default.
- W2959545135 hasConcept C71924100 @default.
- W2959545135 hasConcept C86803240 @default.
- W2959545135 hasConcept C89429830 @default.
- W2959545135 hasConcept C91129048 @default.
- W2959545135 hasConcept C95444343 @default.
- W2959545135 hasConceptScore W2959545135C122302759 @default.
- W2959545135 hasConceptScore W2959545135C12554922 @default.
- W2959545135 hasConceptScore W2959545135C136229726 @default.
- W2959545135 hasConceptScore W2959545135C144796933 @default.