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• W2959600071 abstract "Alzheimer's disease (AD) afflicts an estimated 20 million people worldwide and is the fourth-leading cause of death in the developed world. The most common cause of dementia in older individuals, AD is characterized by neuropathologies including synaptic and neuronal degeneration, amyloid plaques, and neurofibrillary tangles (NTFs). Amyloid plaques are primarily composed of amyloid-beta peptide (Aβ), which accumulates in the brains of patients with AD. Further, small aggregates termed Aβ oligomers are implicated in the synaptic loss and neuronal degeneration underlying early cognitive impairments. Whether Aβ accumulates in part because of dysregulated clearance from the brain remains unclear. The flow of substances (e.g., nutrients, drugs, toxins) in and out of the brain is mediated by the blood-brain-barrier (BBB). The BBB exhibits impairment in AD patients and animal models. The effect of BBB impairment on Aβ, and whether BBB function is affected by non-neurological pathologies that impair peripheral clearance requires further investigation. In particular, impaired peripheral clearance is a feature of nonalcoholic fatty liver disease (NAFLD), a spectrum of liver disorders characterized by accumulation of fat in the liver accompanied by varying degrees of inflammation and hepatocyte injury. NAFLD has reached epidemic proportions, with an estimated prevalence between 20% and 30% of the general population. This chronic condition may influence AD pathogenesis. This review article summarizes the current state of the literature linking NAFLD and AD, highlighting the role of the major Aβ efflux and clearance protein, the LRP-1 receptor, which is abundantly expressed in liver, brain, and vasculature." @default.
• W2959600071 created "2019-07-23" @default.
• W2959600071 creator A5005151827 @default.
• W2959600071 creator A5023760780 @default.
• W2959600071 creator A5049575058 @default.
• W2959600071 creator A5081758138 @default.
• W2959600071 date "2019-07-17" @default.
• W2959600071 modified "2023-10-16" @default.
• W2959600071 title "Liver Dysfunction as a Novel Player in Alzheimer’s Progression: Looking Outside the Brain" @default.
• W2959600071 cites W1147956078 @default.
• W2959600071 cites W1540165847 @default.
• W2959600071 cites W1796655907 @default.
• W2959600071 cites W1964314802 @default.
• W2959600071 cites W1973865177 @default.
• W2959600071 cites W1976936948 @default.
• W2959600071 cites W1982751676 @default.
• W2959600071 cites W1985259299 @default.
• W2959600071 cites W1990027951 @default.
• W2959600071 cites W1992653391 @default.
• W2959600071 cites W1993571512 @default.
• W2959600071 cites W1993812537 @default.
• W2959600071 cites W2003708432 @default.
• W2959600071 cites W2005441052 @default.
• W2959600071 cites W2006035554 @default.
• W2959600071 cites W2010358008 @default.
• W2959600071 cites W2011005493 @default.
• W2959600071 cites W2014538594 @default.
• W2959600071 cites W2014712282 @default.
• W2959600071 cites W2018149927 @default.
• W2959600071 cites W2018477409 @default.
• W2959600071 cites W2022047142 @default.
• W2959600071 cites W2024353040 @default.
• W2959600071 cites W2025688778 @default.
• W2959600071 cites W2025944561 @default.
• W2959600071 cites W2033918288 @default.
• W2959600071 cites W2034275438 @default.
• W2959600071 cites W2034968148 @default.
• W2959600071 cites W2037321375 @default.
• W2959600071 cites W204521712 @default.
• W2959600071 cites W2046677279 @default.
• W2959600071 cites W2049258931 @default.
• W2959600071 cites W2050386832 @default.
• W2959600071 cites W2051218719 @default.
• W2959600071 cites W2052707772 @default.
• W2959600071 cites W2055908419 @default.
• W2959600071 cites W2067825919 @default.
• W2959600071 cites W2073290778 @default.
• W2959600071 cites W2073813663 @default.
• W2959600071 cites W2076890848 @default.
• W2959600071 cites W2078251934 @default.
• W2959600071 cites W2079966013 @default.
• W2959600071 cites W2080797130 @default.
• W2959600071 cites W2082429191 @default.
• W2959600071 cites W2082617364 @default.
• W2959600071 cites W2085872177 @default.
• W2959600071 cites W2085974856 @default.
• W2959600071 cites W2090237611 @default.
• W2959600071 cites W2095212600 @default.
• W2959600071 cites W2096410114 @default.
• W2959600071 cites W2096963202 @default.
• W2959600071 cites W2107233754 @default.
• W2959600071 cites W2108569420 @default.
• W2959600071 cites W2109646121 @default.
• W2959600071 cites W2111200377 @default.
• W2959600071 cites W2116037292 @default.
• W2959600071 cites W2119195037 @default.
• W2959600071 cites W2122372853 @default.
• W2959600071 cites W2140323904 @default.
• W2959600071 cites W2148020885 @default.
• W2959600071 cites W2161230440 @default.
• W2959600071 cites W2162681653 @default.
• W2959600071 cites W2178866977 @default.
• W2959600071 cites W2190740845 @default.
• W2959600071 cites W2191975304 @default.
• W2959600071 cites W2208177230 @default.
• W2959600071 cites W2223511468 @default.
• W2959600071 cites W2297007897 @default.
• W2959600071 cites W2329336071 @default.
• W2959600071 cites W2395867572 @default.
• W2959600071 cites W2563087870 @default.
• W2959600071 cites W2569125128 @default.
• W2959600071 cites W2593993808 @default.
• W2959600071 cites W2595399872 @default.
• W2959600071 cites W2609492054 @default.
• W2959600071 cites W2611878288 @default.
• W2959600071 cites W2772451653 @default.
• W2959600071 cites W2793954600 @default.
• W2959600071 cites W2794867359 @default.
• W2959600071 cites W2799405453 @default.
• W2959600071 cites W2810634108 @default.
• W2959600071 cites W2903957639 @default.
• W2959600071 cites W2905452340 @default.
• W2959600071 cites W2910128841 @default.
• W2959600071 cites W2911147760 @default.
• W2959600071 cites W49725469 @default.
• W2959600071 doi "https://doi.org/10.3389/fnagi.2019.00174" @default.
• W2959600071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6650779" @default.
• W2959600071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31379558" @default.
• W2959600071 hasPublicationYear "2019" @default.
• W2959600071 type Work @default.

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