FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959698076> ?p ?o ?g. }

• W2959698076 endingPage "579" @default.
• W2959698076 startingPage "568" @default.
• W2959698076 abstract "Heart rate variability (HRV) is reduced in cirrhosis and in conditions of systemic inflammation. Whether HRV is associated with cirrhosis decompensation and development of acute-on-chronic liver failure (ACLF) is unknown.To (a) validate wireless remote HRV monitoring in cirrhosis decompensation; (b) determine if severely reduced HRV is a surrogate for inflammation and progression of cirrhosis decompensation; (c) assess if measuring HRV determines prognosis in cirrhosis decompensation.One hundred and eleven patients at risk of cirrhosis decompensation at two clinical sites were monitored for HRV. Standard deviation of all normal beat-beat intervals (SDNN) reflecting HRV was assessed using remote monitoring (Isansys Lifetouch) and/or Holter ECG recording. Clinical outcomes and major prognostic scores were recorded during 90-day follow-up.Reduced HRV denoted by lower baseline SDNN, correlated with severity of decompensation (median 14 (IQR 11-23) vs 33 (25-42); P < 0.001, decompensated patients vs stable outpatient cirrhosis). Furthermore, SDNN was significantly lower in patients developing ACLF compared to those with only decompensation (median 10 (IQR9-12) vs 16 (11-24); P = 0.02), and correlated inversely with MELD and Child-Pugh scores, and C-reactive protein (all P < 0.0001) and white cell count (P < 0.001). SDNN predicted disease progression on repeat measures and appeared an independent predictor of 90-day mortality (12 patients). An SDNN cut-off of 13.25 ms had a 98% negative predictive value.This study demonstrates that remote wireless HRV monitoring identifies cirrhosis patients at high risk of developing ACLF and death, and suggests such monitoring might guide the need for early intervention in such patients. Clinical Trial number: NIHR clinical research network CPMS ID 4949." @default.
• W2959698076 created "2019-07-23" @default.
• W2959698076 creator A5008177500 @default.
• W2959698076 creator A5008293338 @default.
• W2959698076 creator A5024887498 @default.
• W2959698076 creator A5029282864 @default.
• W2959698076 creator A5042702134 @default.
• W2959698076 creator A5047324691 @default.
• W2959698076 creator A5047592599 @default.
• W2959698076 creator A5054723138 @default.
• W2959698076 creator A5056515219 @default.
• W2959698076 creator A5066517663 @default.
• W2959698076 creator A5071666862 @default.
• W2959698076 creator A5079458879 @default.
• W2959698076 creator A5081666714 @default.
• W2959698076 creator A5083735701 @default.
• W2959698076 creator A5089085154 @default.
• W2959698076 creator A5090224526 @default.
• W2959698076 date "2019-07-08" @default.
• W2959698076 modified "2023-10-18" @default.
• W2959698076 title "Significant reduction in heart rate variability is a feature of acute decompensation of cirrhosis and predicts 90-day mortality" @default.
• W2959698076 cites W1971615618 @default.
• W2959698076 cites W1972200139 @default.
• W2959698076 cites W1976490885 @default.
• W2959698076 cites W1995583461 @default.
• W2959698076 cites W1996163396 @default.
• W2959698076 cites W2002116455 @default.
• W2959698076 cites W2007670274 @default.
• W2959698076 cites W2015050260 @default.
• W2959698076 cites W2015750049 @default.
• W2959698076 cites W2035658071 @default.
• W2959698076 cites W2057218072 @default.
• W2959698076 cites W2090586799 @default.
• W2959698076 cites W2098675811 @default.
• W2959698076 cites W2103152385 @default.
• W2959698076 cites W2113499574 @default.
• W2959698076 cites W2128363478 @default.
• W2959698076 cites W2133044262 @default.
• W2959698076 cites W2138123121 @default.
• W2959698076 cites W2148832872 @default.
• W2959698076 cites W2160160703 @default.
• W2959698076 cites W2514899465 @default.
• W2959698076 cites W2569571716 @default.
• W2959698076 cites W2727475156 @default.
• W2959698076 cites W2751247972 @default.
• W2959698076 cites W2782209766 @default.
• W2959698076 doi "https://doi.org/10.1111/apt.15365" @default.
• W2959698076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31286545" @default.
• W2959698076 hasPublicationYear "2019" @default.
• W2959698076 type Work @default.
• W2959698076 sameAs 2959698076 @default.
• W2959698076 citedByCount "26" @default.
• W2959698076 countsByYear W29596980762019 @default.
• W2959698076 countsByYear W29596980762020 @default.
• W2959698076 countsByYear W29596980762021 @default.
• W2959698076 countsByYear W29596980762022 @default.
• W2959698076 countsByYear W29596980762023 @default.
• W2959698076 crossrefType "journal-article" @default.
• W2959698076 hasAuthorship W2959698076A5008177500 @default.
• W2959698076 hasAuthorship W2959698076A5008293338 @default.
• W2959698076 hasAuthorship W2959698076A5024887498 @default.
• W2959698076 hasAuthorship W2959698076A5029282864 @default.
• W2959698076 hasAuthorship W2959698076A5042702134 @default.
• W2959698076 hasAuthorship W2959698076A5047324691 @default.
• W2959698076 hasAuthorship W2959698076A5047592599 @default.
• W2959698076 hasAuthorship W2959698076A5054723138 @default.
• W2959698076 hasAuthorship W2959698076A5056515219 @default.
• W2959698076 hasAuthorship W2959698076A5066517663 @default.
• W2959698076 hasAuthorship W2959698076A5071666862 @default.
• W2959698076 hasAuthorship W2959698076A5079458879 @default.
• W2959698076 hasAuthorship W2959698076A5081666714 @default.
• W2959698076 hasAuthorship W2959698076A5083735701 @default.
• W2959698076 hasAuthorship W2959698076A5089085154 @default.
• W2959698076 hasAuthorship W2959698076A5090224526 @default.
• W2959698076 hasBestOaLocation W29596980762 @default.
• W2959698076 hasConcept C126322002 @default.
• W2959698076 hasConcept C164705383 @default.
• W2959698076 hasConcept C2777214474 @default.
• W2959698076 hasConcept C2777953023 @default.
• W2959698076 hasConcept C2778198053 @default.
• W2959698076 hasConcept C2778721985 @default.
• W2959698076 hasConcept C71635504 @default.
• W2959698076 hasConcept C71924100 @default.
• W2959698076 hasConcept C84393581 @default.
• W2959698076 hasConcept C90924648 @default.
• W2959698076 hasConceptScore W2959698076C126322002 @default.
• W2959698076 hasConceptScore W2959698076C164705383 @default.
• W2959698076 hasConceptScore W2959698076C2777214474 @default.
• W2959698076 hasConceptScore W2959698076C2777953023 @default.
• W2959698076 hasConceptScore W2959698076C2778198053 @default.
• W2959698076 hasConceptScore W2959698076C2778721985 @default.
• W2959698076 hasConceptScore W2959698076C71635504 @default.
• W2959698076 hasConceptScore W2959698076C71924100 @default.
• W2959698076 hasConceptScore W2959698076C84393581 @default.
• W2959698076 hasConceptScore W2959698076C90924648 @default.
• W2959698076 hasFunder F4320310210 @default.
• W2959698076 hasFunder F4320320879 @default.
• W2959698076 hasIssue "5" @default.

• next