FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2959761191> ?p ?o ?g. }

• W2959761191 endingPage "988" @default.
• W2959761191 startingPage "988" @default.
• W2959761191 abstract "Cancer cells interrelate with the bordering host microenvironment that encompasses the extracellular matrix and a nontumour cellular component comprising fibroblasts and immune-competent cells. The tumour microenvironment modulates cancer onset and progression, but the molecular factors managing this interaction are not fully understood. Malignant transformation of a benign tumour is among the first crucial events in colorectal carcinogenesis. The role of tumour stroma fibroblasts is well-described in cancer, but less well-characterized in benign tumours. In the current work we utilized fibroblasts isolated from tubulovillous adenoma, which has high risk for malignant transformation, to study the interaction between benign tumour stroma and the circadian clock machinery. We explored the role of the biological clock in this interplay taking advantage of an experimental model, represented by the co-culture of colon cancer cells with normal fibroblasts or tumour-associated fibroblasts, isolated from human colorectal tumour specimens. When co-cultured with tumour-associated fibroblasts, colon cancer cells showed alterations in their circadian and metabolic parameters, with decreased apoptosis, increased colon cancer cell viability, and increased resistance to chemotherapeutic agents. In conclusion, the interactions among colon cancer cells and tumour-associated fibroblasts affect the molecular clockwork and seem to aggravate malignant cell phenotypes, suggesting a detrimental effect of this interplay on cancer dynamics." @default.
• W2959761191 created "2019-07-23" @default.
• W2959761191 creator A5003631855 @default.
• W2959761191 creator A5013039943 @default.
• W2959761191 creator A5030238472 @default.
• W2959761191 creator A5038093166 @default.
• W2959761191 creator A5041763620 @default.
• W2959761191 creator A5064338064 @default.
• W2959761191 creator A5078675593 @default.
• W2959761191 creator A5080374621 @default.
• W2959761191 date "2019-07-15" @default.
• W2959761191 modified "2023-10-08" @default.
• W2959761191 title "The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes" @default.
• W2959761191 cites W1033849314 @default.
• W2959761191 cites W1569437915 @default.
• W2959761191 cites W1860605136 @default.
• W2959761191 cites W1972632508 @default.
• W2959761191 cites W1976645327 @default.
• W2959761191 cites W1982996260 @default.
• W2959761191 cites W1989228654 @default.
• W2959761191 cites W1996638203 @default.
• W2959761191 cites W1997179110 @default.
• W2959761191 cites W1998478329 @default.
• W2959761191 cites W1999025555 @default.
• W2959761191 cites W2000811716 @default.
• W2959761191 cites W2016397316 @default.
• W2959761191 cites W2017405849 @default.
• W2959761191 cites W2025397614 @default.
• W2959761191 cites W2033976071 @default.
• W2959761191 cites W2038322087 @default.
• W2959761191 cites W2039455025 @default.
• W2959761191 cites W2055624262 @default.
• W2959761191 cites W2057080091 @default.
• W2959761191 cites W2075261412 @default.
• W2959761191 cites W2084074983 @default.
• W2959761191 cites W2087247481 @default.
• W2959761191 cites W2094294962 @default.
• W2959761191 cites W2094839843 @default.
• W2959761191 cites W2124809927 @default.
• W2959761191 cites W2133050919 @default.
• W2959761191 cites W2143210222 @default.
• W2959761191 cites W2144095565 @default.
• W2959761191 cites W2163531378 @default.
• W2959761191 cites W2164498509 @default.
• W2959761191 cites W2234675074 @default.
• W2959761191 cites W2259556701 @default.
• W2959761191 cites W2283970331 @default.
• W2959761191 cites W2313314927 @default.
• W2959761191 cites W2336973027 @default.
• W2959761191 cites W2424342676 @default.
• W2959761191 cites W2460593466 @default.
• W2959761191 cites W2472792300 @default.
• W2959761191 cites W2512899508 @default.
• W2959761191 cites W2560653496 @default.
• W2959761191 cites W2561632327 @default.
• W2959761191 cites W2591253403 @default.
• W2959761191 cites W2771947879 @default.
• W2959761191 cites W2801706878 @default.
• W2959761191 cites W2823321225 @default.
• W2959761191 cites W2883820216 @default.
• W2959761191 cites W2911671599 @default.
• W2959761191 cites W2917837889 @default.
• W2959761191 doi "https://doi.org/10.3390/cancers11070988" @default.
• W2959761191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6678177" @default.
• W2959761191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31311174" @default.
• W2959761191 hasPublicationYear "2019" @default.
• W2959761191 type Work @default.
• W2959761191 sameAs 2959761191 @default.
• W2959761191 citedByCount "24" @default.
• W2959761191 countsByYear W29597611912019 @default.
• W2959761191 countsByYear W29597611912020 @default.
• W2959761191 countsByYear W29597611912021 @default.
• W2959761191 countsByYear W29597611912022 @default.
• W2959761191 countsByYear W29597611912023 @default.
• W2959761191 crossrefType "journal-article" @default.
• W2959761191 hasAuthorship W2959761191A5003631855 @default.
• W2959761191 hasAuthorship W2959761191A5013039943 @default.
• W2959761191 hasAuthorship W2959761191A5030238472 @default.
• W2959761191 hasAuthorship W2959761191A5038093166 @default.
• W2959761191 hasAuthorship W2959761191A5041763620 @default.
• W2959761191 hasAuthorship W2959761191A5064338064 @default.
• W2959761191 hasAuthorship W2959761191A5078675593 @default.
• W2959761191 hasAuthorship W2959761191A5080374621 @default.
• W2959761191 hasBestOaLocation W29597611911 @default.
• W2959761191 hasConcept C121608353 @default.
• W2959761191 hasConcept C142724271 @default.
• W2959761191 hasConcept C16930146 @default.
• W2959761191 hasConcept C203014093 @default.
• W2959761191 hasConcept C204232928 @default.
• W2959761191 hasConcept C2776107976 @default.
• W2959761191 hasConcept C2909706936 @default.
• W2959761191 hasConcept C31033888 @default.
• W2959761191 hasConcept C502942594 @default.
• W2959761191 hasConcept C52124034 @default.
• W2959761191 hasConcept C526805850 @default.
• W2959761191 hasConcept C54355233 @default.
• W2959761191 hasConcept C555283112 @default.
• W2959761191 hasConcept C71924100 @default.

• next